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Cianidanol

Cianidanol
Cianidanol structure
CAS No.
154-23-4
Chemical Name:
Cianidanol
Synonyms
kb-53;CATECHIN;catergen;(2R,3S)-;Cianidano;D-CATECHIN;cianidanol;d-catechol;Cyanidanol;Drenoliver
CBNumber:
CB0428149
Molecular Formula:
C15H14O6
Formula Weight:
290.27
MOL File:
154-23-4.mol

Cianidanol Properties

Melting point:
175-177 °C (anhydrous)(lit.)
alpha 
D18 +16 to +18.4°
Boiling point:
352.36°C (rough estimate)
Density 
1.2451 (rough estimate)
refractive index 
1.4359 (estimate)
storage temp. 
2-8°C
form 
neat
pka
9.54±0.10(Predicted)
Merck 
14,1902
InChIKey
PFTAWBLQPZVEMU-DZGCQCFKSA-N
CAS DataBase Reference
154-23-4
FDA UNII
8R1V1STN48
NCI Dictionary of Cancer Terms
catechin
EPA Substance Registry System
2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3S)- (154-23-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  DJ3450000
8-10-23
HS Code  29329990
Toxicity LD50 oral in rat: > 10gm/kg

Cianidanol price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 43412 (+)-Catechin analytical standard 154-23-4 10mg $326 2021-03-22 Buy
Sigma-Aldrich 1096790 (+)-Catechin United States Pharmacopeia (USP) Reference Standard 154-23-4 25mg $350 2021-03-22 Buy
TCI Chemical C0705 (+)-Catechin Hydrate >97.0%(HPLC) 154-23-4 1g $65 2018-11-22 Buy
TCI Chemical C0705 (+)-Catechin Hydrate >97.0%(HPLC) 154-23-4 10g $340 2018-11-22 Buy
Sigma-Aldrich PHR1963 (+)-Catechin Pharmaceutical Secondary Standard; Certified Reference Material 154-23-4 50mg $225 2021-03-22 Buy

Cianidanol Chemical Properties,Uses,Production

Chemical Properties

Tan Solid

Uses

procollagen production inhibitoe, hepatoprotectant

Uses

(+)-Catechin is a flavonoid found primarily in higher woody plants as (+)-Catechin along with (-)-Epicatechin (cis form). Antidiarrheal.

Uses

Labelled (+)-Catechin (C217500). (+)-Catechin is a flavonoid found primarily in higher woody plants as (+)-Catechin along with (-)-Epicatechin (cis form). Antidiarrheal.

Uses

Cianidanol, also known as (+)-catechin; (+)-3,3′4′,5,7-flavanepentol; 3,3′,4′, 5,7-pentahydroxyflavane, [R,3S]-2-[3,4-dihydroxyphenyl]-3,4-dihydro-1[2H]- benzopyran-3,4,7-triol, or 2-(3,4-dihydroxyphenyl)-3,4-dihydro-(2r-trans)-2h- 1-benzopyran-7-triol, is a flavonoid associated with a variety of blood disorders. An association of cianidanol and immune hemolytic anemia and thrombocytopenia has been suggested in numerous case reports. In several reports, the presence of flavonoid-dependent antibodies against red blood cells is evident with cianidanol combining with erythrocyte membranes and inducing development of autoantibodies and antibodies.Several patients had platelet antibodies with increased serum-bindable IgG values without the presence of cianidanol and several with high platelet-associated IgG levels.Antibodies against cianidanol were not detectable in certain cases.The hemolytic anemia caused acute renal failure in some patients and can be life threatening, leading to fatalities. Upon cessation of treatment with cianidanol, hematology appears to return to normal over time.
These side effects do not appear to be specific to cianidanol as the formation of IgE and IgG antibodies to troxerutin (Venoruton) and silymarin (Kegalon) was also evident with patients presenting with fever, skin eruptions, and intravascular hemolysis often demonstrating high IgG titers.Furthermore, cianidanol-induced hemolysis might also occur after sensitization by other flavonoids including rutin.

Definition

ChEBI: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.

brand name

Ausoliver;Cirramina;Transepar.

World Health Organization (WHO)

Cianidanol, which is extracted from the tropical plant Uncaria gambir, was introduced in 1976 as an adjunct in the treatment of liver disorders. Following a cluster of cases of haemolytic anaemia reported in 1985 from Naples, Italy, four of which were fatal, the company suspended sales worldwide. Although subsequently reintroduced in Switzerland and France for the treatment of acute and chronic hepatitis-B, it was later definitively withdrawn in Switzerland on detailed reassessment and the manufacturer has now withdrawn the product worldwide.

Cianidanol Preparation Products And Raw materials

Raw materials

Preparation Products


Cianidanol Suppliers

Global( 291)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20890 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
+86 0531-67809011 sales@sdzschem.com CHINA 2941 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58

View Lastest Price from Cianidanol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-17 (+)-Catechin 154-23-4
154-23-4
US $6.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-11-15 catechin,Cianidanol
154-23-4
US $40.00 / KG 1000KG 99.9% 100tons Hebei Yirun Sega Biological Technology Co. Ltd
2021-07-13 Cianidanol
154-23-4
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

Cianidanol Spectrum


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