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Parthenolide

Parthenolide
Parthenolide structure
CAS No.
20554-84-1
Chemical Name:
Parthenolide
Synonyms
PTL;Nsc157035;Aids007764;Parthelide;Aids-007764;Parthenolide;PartheNAlide;Parthenolides;parthenolider;Parthenolide>
CBNumber:
CB0446848
Molecular Formula:
C15H20O3
Formula Weight:
248.32
MOL File:
20554-84-1.mol

Parthenolide Properties

Melting point:
115-116 °C (lit.)
alpha 
D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)
Boiling point:
394.1±42.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
-20°C
form 
White solid
Merck 
14,7048
CAS DataBase Reference
20554-84-1
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xi,C,F
Risk Statements  11-34
Safety Statements  22-24/25-45-36/37/39-26-16
WGK Germany  3
RTECS  LY4220000
HS Code  29322090

Parthenolide price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 512732 Parthenolide 20554-84-1 50mg $74.92 2021-12-16 Buy
Sigma-Aldrich 1500400 Parthenolide United States Pharmacopeia (USP) Reference Standard 20554-84-1 25mg $176 2021-12-16 Buy
TCI Chemical P1982 Parthenolide >97.0%(HPLC) 20554-84-1 25mg $83 2021-12-16 Buy
TCI Chemical P1982 Parthenolide >97.0%(HPLC) 20554-84-1 100mg $247 2021-12-16 Buy
Cayman Chemical 70080 Parthenolide ≥98% 20554-84-1 25mg $30 2021-12-16 Buy

Parthenolide Chemical Properties,Uses,Production

Description

Parthenolide is an allergen in feverfew (Tanacetum parthenarium).

Chemical Properties

White solid

Uses

Antiinflammatory;MAP kinase inhibitor

Uses

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.

Uses

Parthenolide is an anti-inflammatory agent used in the treatment of ischemic injury. Also acts as an anti-tumor and anti0leukemia agent targetting acute myeloid leukemia.

Definition

ChEBI: A sesquiterpene lactone and active principle of Feverfew (Tanacetum parthenium).

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

The active principle of feverfew (Chrysanthemum parthenium), widely used as a herbal remedy for arthritis and migraine and as a febrifuge. Parthenolide is antisecretory, anti-inflammatory, spasmolytic and inhibits the release of 5-HT from blood platelets. Also inhibits generation of leukotriene B 4 and thromboxane B 2 .

Biochem/physiol Actions

Parthenolide is a sesquiterpene lactone present abundantly in the leaves and flowers of Tanacetum parthenium. It exhibits anti-cancer properties for the treatment of invasive cancers. Parthenolide exhibits therapeutic effects against inflammation and migraine. It plays a role in signal transduction and activation of transcription (STAT)-inhibition-mediated transcriptional repression of pro-apoptotic genes.

Contact allergens

Parthenolide is a sesquiterpene lactone found Asteraceae- Compositae such as feverfew (Tanacetum parthenium Schultz-Bip.) or congress grass (Parthenium hysterophorus L.).

Parthenolide Preparation Products And Raw materials

Raw materials

Preparation Products


Parthenolide Suppliers

Global( 333)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 376 58
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9134 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 968 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com China 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5943 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58

View Lastest Price from Parthenolide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-23 parthenolider
20554-84-1
US $50.00 / g 2g 99 10000 kilograms/month Hebei Yime New Material Technology Co., Ltd.
2021-11-17 Factory Price Parthenolide 20554-84-1
20554-84-1
US $85.00 / g 20mg ≥98% 1000.00 KGS NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-11-17 Natural Plant Extracts Parthenolide 20554-84-1 High Purity HPLC>98%
20554-84-1
US $93.00 / g 10mg 98.00% HPLC 100.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.

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