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MYXOTHIAZOL

MYXOTHIAZOL structure

CAS No.: 76706-55-3

Chemical Name:: MYXOTHIAZOL

Synonyms: Myxothiazo;MYXOTHIAZOL;5-dimethoxy-4-methyl-;myxothiazolfrommyxobacterium;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;myxothiazol from myxobacterium*myxococcus fulvus;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-

CBNumber:: CB0453976

Molecular Formula:: C25H33N3O3S2

Molecular Weight:: 487.68

MDL Number:: MFCD00043397

MOL File:: 76706-55-3.mol

Last updated:2023-04-23 13:52:06

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MYXOTHIAZOL Properties

Boiling point	679.6±65.0 °C(Predicted)
Density	1.158±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow
pka	14.07±0.50(Predicted)
FDA UNII	6VY98BQ7NB

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264-P270-P301+P310-P405-P501
Hazard Codes	T+
Risk Statements	28
Safety Statements	28-36/37-45
RIDADR	UN 3462 6.1/PG 1
WGK Germany	3
RTECS	QH7580000
F	10
HazardClass	6.1(b)
PackingGroup	III

MYXOTHIAZOL price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T5580	Myxothiazol from Myxococcus fulvus Mx f85, ≥98% (HPLC)	76706-55-3	1mg	$111	2024-03-01	Buy
Sigma-Aldrich	T5580	Myxothiazol from Myxococcus fulvus Mx f85, ≥98% (HPLC)	76706-55-3	5mg	$444	2024-03-01	Buy
American Custom Chemicals Corporation	INB0001302	MYXOTHIAZOL 98.00%	76706-55-3	5MG	$505.27	2021-12-16	Buy
ChemScene	CS-0043613	Myxothiazol ≥99.0%	76706-55-3	5mg	$730	2021-12-16	Buy
ChemScene	CS-0043613	Myxothiazol ≥99.0%	76706-55-3	1mg	$290	2021-12-16	Buy

Product number	Packaging	Price	Buy
T5580	1mg	$111	Buy
T5580	5mg	$444	Buy
INB0001302	5MG	$505.27	Buy
CS-0043613	5mg	$730	Buy
CS-0043613	1mg	$290	Buy

MYXOTHIAZOL Chemical Properties,Uses,Production

Uses

Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.

Definition

ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S

Biochem/physiol Actions

Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.

MYXOTHIAZOL Preparation Products And Raw materials

Raw materials

Preparation Products

MYXOTHIAZOL Suppliers

Global( 22)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	14059	65
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 18892239720	psaitong@jm-bio.com	China	12308	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
Guangdong wengjiang Chemical Reagent Co., Ltd.	0751-2815688 13927872512	3007421951@qq.com	China	10084	58
Zhejiang Huida Biotech Co., LTD	0571-89903882 13626641628	jiangnan@huidabiotech.com	China	3661	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840 15801484223	psaitong@jm-bio.com	China	29834	58
Zhejiang Huida Biotech Co., LTD	0571-0571-89903882 15990081639	sunshixuan@huidabiotech.com	China	3705	58
Shanghai Maclean Biochemical Technology Co., LTD	021-50706066 15221275939	shenlinxing@macklin.cn	China	29803	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
BOC Sciences	65
Sigma-Aldrich	80
Beijing Jin Ming Biotechnology Co., Ltd.	58
Shanghai Hongye Biotechnology Co. Ltd	58
Guangdong wengjiang Chemical Reagent Co., Ltd.	58
Zhejiang Huida Biotech Co., LTD	58
Beijing Jin Ming Biotechnology Co., Ltd.	58
Zhejiang Huida Biotech Co., LTD	58
Shanghai Maclean Biochemical Technology Co., LTD	58

76706-55-3(MYXOTHIAZOL)Related Search:

2-Isopropyl-4-methyl thiazole 3-METHYL-1,5-HEPTADIENE 1,5-HEXADIEN-3-OL 2-Ethyl-4-methyl thiazole 4-METHYL-1-PENTEN-3-OL

2,4-Dimethylthiazole TRANS-2-METHYL-4-HEXEN-3-OL 2-isopropylthiazole 2-ETHYLTHIAZOLE 1,5-HEPTADIEN-4-OL

4-METHYL-1,5-HEPTADIENE MYXOTHIAZOL

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MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS MYXOTHIAZOL 5-dimethoxy-4-methyl- 7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide myxothiazol from myxobacterium*myxococcus fulvus MYXOTHIAZOL, VIAL WITH 10 MG* MYXOTHIAZOL FROM MYXOBACTERIUM 95% myxothiazolfrommyxobacterium 2,6-Heptadienamide, 7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)- 2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl- Myxothiazo 2,6-Heptadienamide, 7-[2'-[(1S,2E,4E)-1,6-dimethyl-2,4-heptadien-1-yl][2,4'-bithiazol]-4-yl]-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)- 76706-55-3 C25H33N3O3S2 Antibiotics G-M Antibiotics Antibiotics A to Z BioChemical Inhibits an EnzymeNitric Oxide and Cell Stress Mitochondrial InhibitorsAntibiotics Antibiotics Antibiotics A to Antibiotics G-MAntibiotics AntifungalAntibiotics Cell Stress Chemical Structure Class Mechanism of Action Peptides Spectrum of Activity