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Norethindrone

Norethindrone
Norethindrone structure
CAS No.
68-22-4
Chemical Name:
Norethindrone
Synonyms
ENT;NET;Elk;EPB1;Cek6;Elkh;Hek6;EPTH2;EPHB1;EPHT2
CBNumber:
CB0455127
Molecular Formula:
C20H26O2
Formula Weight:
298.42
MOL File:
68-22-4.mol

Norethindrone Properties

Melting point:
205-206 °C(lit.)
Boiling point:
379.83°C (rough estimate)
alpha 
D20 -31.7° (chloroform); D20 -25° (chloroform)
Density 
1.0766 (rough estimate)
refractive index 
1.4800 (estimate)
storage temp. 
-20°C Freezer
solubility 
chloroform: ≥50 mg/mL, clear, colorless
form 
powder
color 
white to off-white
Merck 
6697
BRN 
1915671
InChIKey
VIKNJXKGJWUCNN-XGXHKTLJSA-N
CAS DataBase Reference
68-22-4(CAS DataBase Reference)
NIST Chemistry Reference
Norethindrone(68-22-4)
EPA Substance Registry System
19-Norpregn-4-en- 20-yn-3-one, 17-hydroxy-, (17.alpha.)-(68-22-4)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn
Risk Statements  40-36/37/38-20/21/22
Safety Statements  22-36/37/39-45-37/39-26
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  RC8975000
HS Code  29144000
Hazardous Substances Data 68-22-4(Hazardous Substances Data)
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.

Norethindrone price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N4128 19-Norethindrone ≥98%, powder 68-22-4 1g $136 2018-11-20 Buy
Sigma-Aldrich 1469005 Norethindrone United States Pharmacopeia (USP) Reference Standard 68-22-4 200mg $352.8 2018-11-20 Buy
Cayman Chemical 20941 Norethindrone ≥98% 68-22-4 250mg $25 2018-11-19 Buy
Cayman Chemical 20941 Norethindrone ≥98% 68-22-4 500mg $45 2018-11-19 Buy
Sigma-Aldrich N4128 19-Norethindrone ≥98%, powder 68-22-4 250mg $76.7 2018-11-20 Buy

Norethindrone Chemical Properties,Uses,Production

Description

Norethindrone is a progestin (a synthetic substance with properties similar to progesterone) that is best known as the first female oral contraceptive, or the “pill.”Norethindrone’s global impact on society and culture has made it one of the most important inventions in history.

Chemical Properties

Off-White to Pale Yellow Solid

History

The development of norethindrone as a female oral contraceptive took place indirectly over 30 years as a result of steroid research.This research accelerated in the 1930s when structures and medical applications of steroidal compounds were determined.Steroids are lipids, which include cholesterol, bile salts,and sex hormones,that are characterized by a structure of three fused six-carbon rings and a five-carbon ring.
In 1957, both norethindrone and norethynodrel were approved by the Food and Drug Administration (FDA) for treating menstrual problems and infertility. In 1960, the FDA approved Searle's norethynodrel under the trade name Enovid. Norethindrone was approved as an oral contraceptive in 1962 under the trade name Ortho-Novum.

Uses

Progestin contraceptives work by producing pregnant-like conditions in a female to preventovulation.During pregnancy, progesterone is released by the placenta during development ofthe fetus.This in turn suppresses development of egg follicles and ovulation. Progestins mimicthis condition and thus prevent or delay ovulation.Oral contraceptives currently use progestinand estrogen in combination to prevent ovulation and thicken cervical mucus.The latter makeit harder for sperm to enter the uterus and for an egg to implant on the uterine wall.

Uses

progestogen

Uses

A synthetic progestin

Uses

Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen

Definition

ChEBI: A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.

brand name

Camila (Barr); Errin (Barr); Micronor (OrthoMcNeil); Nor-QD (Watson); Norlutin (Parke-Davis).

General Description

Norethindrone, 17α-ethinyl-19-nortestosterone, and itsΔ5(10)-isomer, norethynodrel, might appear at first glance tobe subtle copies of each other. One would predict that theΔ5(10)-double bond would isomerize in the stomach’s acid tothe Δ4-position. However, the two drugs were actually developedsimultaneously and independently; hence, neither can beconsidered a copy of the other. Furthermore, norethindrone isabout 10 times more active than norethynodrel, indicating that isomerization is not as facile in vivo asone might predict. Although they are less active than progesteronewhen given subcutaneously, they have the importantadvantage of being orally active. The discovery of the potentprogestin activity of 17α-ethinyltestosterone (ethisterone) and19-norprogesterone preceded the development of these potentprogestins. Both are orally active, with the 17α-ethinyl groupblocking oxidation to the less active 17-one. The rich electrondensity of the ethinyl group and the absence of the 19-methylgroup greatly enhance progestin activity. Both compoundswere of great importance as progestin components of oralcontraceptives, although currently, use of norethynodrel isminimal. Norethindrone, USP, and norethindrone acetate,USP, are widely used for all the usual indications of the progestins,as well as being components of oral contraceptives.Because these compounds retain key features of the testosteronestructure, including the 17β-OH, it is not surprisingthat they possess some androgenic side effects.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Mddly toxic by ingestion. Human systemic effects by ingestion: dermatitis and androgenic effects. Human teratogenic effects: developmental abnormalities of the musculoskeletal system and urogenital system; and behavioral effects in the newborn. Human reproductive effects: spermatogenesis; testes, epididymis, sperm duct changes; impotence; male breast development; other male effects; ovaries, fallopian tube changes; menstrual cycle effects; postpartum effects; changes in female fertility. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Norethindrone Preparation Products And Raw materials

Raw materials

Preparation Products


Norethindrone Suppliers

Global( 265)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Meihua Biological Technology Co.,Ltd
15175972705
031145896235 sales@hbmeihua.cn CHINA 211 58
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21935 58
Beijing Cooperate Pharmaceutical Co.,Ltd.
+86-10-60279497 +86(0)15646567669
+86-10-60279497 sales01@cooperate-pharm.com CHINA 1529 55
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Rixing Chemical CO.,LTD
13237129059
- info@rixingchemi.com CHINA 235 55
PI & PI BIOTECH INC.
020-81716320
020-81716319 Sales@pipitech.com CHINA 2543 55
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 892 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58

View Lastest Price from Norethindrone manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-05 Norethindrone
68-22-4
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-12-16 Norethindrone
68-22-4
US $1.00 / kg 1kg 98% 100MT career henan chemical co
2018-07-20 Norethindrone
68-22-4
US $10.00 / KG 10G 99% 500kg/month Hebei Chisure Biotechnology Co., Ltd.

Norethindrone Spectrum


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