ChemicalBook >> CAS DataBase List >>3-Hydroxyazetidine hydrochloride
3-Hydroxyazetidine hydrochloride
- CAS No.
- 18621-18-6
- Chemical Name:
- 3-Hydroxyazetidine hydrochloride
- Synonyms
- AZETIDIN-3-OL HYDROCHLORIDE;3-AZETIDINOL HYDROCHLORIDE;3-HYDROXYAZETIDINE HCL;Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride;AZETAN-2-ONE;BUTTPARK 75\04-67;Azetidine-3-ol.Hcl;Baricitinib-009-HCl;3-hydroxyazatidine HCl;3-Hydroxyl-azetidine HCl
- CBNumber:
- CB0455455
- Molecular Formula:
- C3H8ClNO
- Molecular Weight:
- 109.55
- MDL Number:
- MFCD02683887
- MOL File:
- 18621-18-6.mol
- MSDS File:
- SDS
Last updated:2024-04-22 14:31:47
| Melting point | 85-90 °C |
|---|---|
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water, DMSO, methanol. |
| Sensitive | Hygroscopic |
| Stability | Hygroscopic |
| InChI | InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H |
| InChIKey | UQUPQEUNHVVNKW-UHFFFAOYSA-N |
| SMILES | C1(O)CNC1.Cl |
| CAS DataBase Reference | 18621-18-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| Hazard Codes | C,Xi,Xn | |||||||||
| Risk Statements | 36/37/38-41-37/38-22 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| RIDADR | UN1759 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Harmful/Corrosive | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
3-Hydroxyazetidine hydrochloride price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 680079 | 3-Hydroxyazetidine hydrochloride 97% | 18621-18-6 | 1g | $53.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 680079 | 3-Hydroxyazetidine hydrochloride 97% | 18621-18-6 | 5g | $117.6 | 2024-03-01 | Buy |
| TCI Chemical | H1264 | 3-Hydroxyazetidine Hydrochloride >98.0%(N) | 18621-18-6 | 1g | $46 | 2024-03-01 | Buy |
| TCI Chemical | H1264 | 3-Hydroxyazetidine Hydrochloride >98.0%(N) | 18621-18-6 | 5g | $137 | 2024-03-01 | Buy |
| Alfa Aesar | H25842 | 3-Hydroxyazetidine hydrochloride, 97% | 18621-18-6 | 1g | $84.65 | 2024-03-01 | Buy |
3-Hydroxyazetidine hydrochloride Chemical Properties,Uses,Production
Description
3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.
Chemical Properties
white crystal
Uses
3-Hydroxyazetidine hydrochloride is an building block used in a recent synthesis of a fluoroquinolone antibiotic and a useful intermediate in the synthesis of polypeptides.
Uses
3-Hydroxyazetidine hydrochloride is a useful intermediate in the synthesis of polypeptides.
Synthesis
A solution of l-(diphenylmethyl)-3-hydroxy azetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker (4 atm). After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94%).
Synthesis of 3-Hydroxyazetidine hydrochloride from 1-(DIPHENYLMETHYL)-3-HYDROXYAZETIDINE HYDROCHLORIDE
3-Hydroxyazetidine hydrochloride Preparation Products And Raw materials
Raw materials
Methanol
Epichlorohydrin
Isopropyl alcohol
Sodium carbonate
1-Azetidinecarboxylic acid, 2-hydroxy-, 1,1-dimethylethyl ester
1of4
Preparation Products
Global( 514)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 9116 | 58 |
| Lianhe Aigen Pharmatech Co.,Ltd. | +86-18918657159 +86-18918657159 | sales-Aigen@lianhetech.com | China | 305 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5993 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5964 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 476 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
View Lastest Price from 3-Hydroxyazetidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | 3-Hydroxyazetidine hydrochloride
18621-18-6
|
US $200.00-95.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-04-12 | 3-Hydroxyazetidine hydrochloride
18621-18-6
|
US $0.00 / kg | 1kg | 99% | 2000ton | Shaanxi Haibo Biotechnology Co., Ltd | |
 |
2024-02-26 | 3-Hydroxyazetidine hydrochloride
18621-18-6
|
US $0.00-0.00 / kg | 1kg | 99% | Kgs | BTC Nantong Pharmaceuticals Technology Co.,Ltd |
-
- 3-Hydroxyazetidine hydrochloride
18621-18-6
- US $200.00-95.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- 3-Hydroxyazetidine hydrochloride
18621-18-6
- US $0.00 / kg
- 99%
- Shaanxi Haibo Biotechnology Co., Ltd
-
- 3-Hydroxyazetidine hydrochloride
18621-18-6
- US $0.00-0.00 / kg
- 99%
- BTC Nantong Pharmaceuticals Technology Co.,Ltd
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18621-18-6
8621-18-6
C3H7ClNO
C3H8NOCl
C3H7NOHCl
C3H7NOClH
Azetidines
Amino Acids & Derivatives
Heterocyclic Building Blocks
N-Containing
Others
B-Amino
Amino Acids 13C, 2H, 15N
pharmacetical
Azetidine
Alcohols and Derivatives
Heterocycles