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O-Phospho-L-serine

CAS No.
407-41-0
Chemical Name:
O-Phospho-L-serine
Synonyms
L O;P-ser;L-SOP;L-O-(RG);Seriphos;P-serine;Fosforina;3-P-SERINE;Phospho Ser;Phospho?Ser
CBNumber:
CB0456205
Molecular Formula:
C3H8NO6P
Molecular Weight:
185.07
MDL Number:
MFCD00065935
MOL File:
407-41-0.mol
MSDS File:
SDS
Last updated:2024-03-28 13:39:29

O-Phospho-L-serine Properties

Melting point 190 °C(lit.)
alpha [α]D20 +14~+18°(c=5,dil.HCl)
Boiling point 475.4±55.0 °C(Predicted)
Density 1.809±0.06 g/cm3(Predicted)
vapor pressure 0Pa at 20℃
storage temp. under inert gas
solubility H2O: 50 mg/mL hot, clear, colorless to slightly yellow
form Crystalline Powder
pka pK1:2.08;pK2:5.65;pK3:9.74 (25°C)
color White
Water Solubility 28.34g/L at 20℃
Merck 14,7363
BRN 1726826
InChIKey BZQFBWGGLXLEPQ-UWTATZPHSA-N
CAS DataBase Reference 407-41-0(CAS DataBase Reference)
FDA UNII VI4F0K069V

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes  Xn
Risk Statements  21/22
Safety Statements  36/37
RIDADR  UN 3261 8 / PGII
WGK Germany  3
10
HS Code  29225090
NFPA 704
0
3 0

O-Phospho-L-serine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P3430 Monoclonal Anti-Phosphoserine antibody produced in mouse clone PSR-45, ascites fluid 407-41-0 100μL $208 2024-03-01 Buy
Sigma-Aldrich P3430 Monoclonal Anti-Phosphoserine antibody produced in mouse clone PSR-45, ascites fluid 407-41-0 0.2mL $270.4 2024-03-01 Buy
Sigma-Aldrich P0878 O-Phospho-L-serine 407-41-0 1g $32.7 2024-03-01 Buy
Sigma-Aldrich 72983 O-Phospho-L-serine certified reference material, TraceCERT 407-41-0 100mg $180 2024-03-01 Buy
Sigma-Aldrich 5.09705 L-Serine-O-phosphate - CAS 407-41-0 - Calbiochem 407-41-0 1g $63.1 2022-05-15 Buy
Product number Packaging Price Buy
P3430 100μL $208 Buy
P3430 0.2mL $270.4 Buy
P0878 1g $32.7 Buy
72983 100mg $180 Buy
5.09705 1g $63.1 Buy

O-Phospho-L-serine Chemical Properties,Uses,Production

Description

O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.

Chemical Properties

White powder

Uses

roborant

Uses

O-Phospho-L-Serine is an agonist of the group III metabotropic glutamate receptors mGluR4a and mGluR6 (EC50s = 2-5 μM). It mimics the phosphatidylserine head group and has been shown to inhibit the proliferation of microglia and to enhance neuronal differentiation of progenitor cells.

Uses

L-O-Phosphoserine is the catalytic domain of human protein kinase C β II when complexed with a malemide inhibitor. It is also used in the purification of the Epstein-Barr virus nuclear antigen 2A.

Definition

ChEBI: O-phospho-L-serine is the L-enantiomer of O-phosphoserine. It has a role as an EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, an EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor, an EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor and a mouse metabolite. It is a conjugate acid of an O-phosphonato-L-serine(2-). It is an enantiomer of an O-phospho-D-serine.

General Description

Monoclonal Anti-Phosphoserine (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse.

Flammability and Explosibility

Not classified

Biological Activity

Group III metabotropic glutamate receptor agonist; analog of L-AP4 (L-(+)-2-Amino-4-phosphonobutyric acid ). Inhibits proliferation and enhances neuronal differentiation in progenitor cells.

Biochem/physiol Actions

Protein phosphorylation and dephosphorylation are basic signaling mechanisms that modify protein function in eukaryotic cells. Phosphorylation is a rare posttranslational event in normal tissues, however, the abundance of phosphorylated cellular proteins increases several folds following various activation processes. The main amino acids that are phosphorylated are tyrosine, serine, or threonine (pTyr/pSer/pThr), each having specific kinases that phosphorylate them and specific phosphatases that dephosphorylate them. Mono and polyclonal antibodies directed against phosphorylated residues were generated and found useful as analytical and preparative tools by enabling the identification, quantification, and immunoaffinity isolation of phosphorylated cellular proteins.

storage

Room temperature

Purification Methods

Recrystallise the phospho-serine by dissolving 10g in H2O (150mL) at 25o, stirring for up to 20minutes. Undissolved material is filtered off (Büchner), and 95% EtOH (85mL) is added dropwise during 4minutes, and set aside at 25o for 3hours, then at 3o overnight. The crystals are washed with 95% EtOH (100mL), then dry Et2O (50mL), and dried in a vacuum (yield 6.5g). A further quantity (1.5g) can be obtained by keeping the mother liquors and washings at -10o for 1 week. The DL-isomer has m 167-170o(dec) after recrystallisation from H2O/EtOH or MeOH. [Neuhaus & Korkes Biochemical Preparations 6 75 1958, Neuhaus & Byrne J Biol Chem 234 113 1959, IR: F.lsch & Mellander Acta Chem Scand 11 1232 1957, Beilstein 4 IV 3120.]

O-Phospho-L-serine Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 199)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Saisier Technology Co., LTD
+8618400010335 admin@hbsaisier.cn China 143 58
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 7836 58
Hubei xin bonus chemical co. LTD
86-13657291602 linda@hubeijusheng.com CHINA 22968 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 47465 58
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Richest Group Ltd
18017061086 oled@richest-group.com CHINA 5601 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196 sale04@alfachem.cn China 12321 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hubei Ipure Biology Co., Ltd
+8613367258412 ada@ipurechemical.com China 10326 58
Hefei TNJ Chemical Industry Co.,Ltd.
0551-65418671 sales@tnjchem.com China 34572 58

View Lastest Price from O-Phospho-L-serine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
O-Phospho-L-serine pictures 2024-03-28 O-Phospho-L-serine
407-41-0
US $6.00 / KG 1KG 99% 2000KG/MONTH Hebei Saisier Technology Co., LTD
O-Phospho-L-serine pictures 2024-01-09 O-Phospho-L-serine
407-41-0
US $0.00 / kg 1kg 99% 1000000 Hebei Jingbo New Material Technology Co., Ltd
O-Phospho-L-serine pictures 2023-03-12 O-Phospho-L-serine
407-41-0
US $0.00 / kg 1kg 98.0%min 100kg LY Global chemicals co.,ltd .
L-O-PHOSPHOSERINE L-SERINE-O-PHOSPHATE L-PHOSPHOSERINE H-SER(PO3H2)-OH PHOSPHATIDYLETHANOLAMINE(EGG)(RG) O-Phosho-L-serine O-Phosphorylserine Phospho-L-serine Serine O-phosphate (S)-2-aMino-3-(phosphonooxy)propanoic acid L-Serine, O-phosphono- L-O-Phosphoserine Monoclonal Anti-Phosphoserine?Agarose antibody produced in mouse Monoclonal Anti-Phosphoserine?Biotin antibody produced in mouse Monoclonal Anti-Phosphoserine antibody produced in mouse Monoclonal Anti-Phosphoserine?FITC antibody produced in mouse Phospho Ser Phospho?Ser H-Ser(PO3H2) L-Ser(H2PO3)-OH O-Phospho-L-serine≥ 99% (Titration) H-SER(P)-OH H-SER(H2PO3)-OH L-2-AMINO-3-HYDROXYPROPANOIC ACID 3-PHOSPHATE PHOSPHOSERINE PHOSPHOSERINE ANTIBODY INHIBITOR O-PHOSPHORYL-L-SERINE dexfosfoserine L-(+)-serine 3-(dihydrogen phosphate) L-Phosphoserine Anhydrous Phosphoserinebariumsalt O-PHOSPHO-L-SERINE SERINE(PO3H2)-OH O-phosphoserine Serine phosphate (2S)-2-amino-3-phosphonooxy-propanoic acid L-O-(RG) plasmenylserine L-Serine monophosphoric acid L-O-Phosphoserine 98+% T L-2-Amino-3-hydroxypropanoic acid 3-phosphate, L-Serine O-phosphate, L-SOP L-O-Serine phosphate L-Serine, dihydrogen phosphate (ester) Seriphos Fosforina L-Serine dihydrogen phosphate L-Serine O-phosphoric acid 3-phospho-L-serine 3-phosphoserine 3-phospho-serine 3-P-SERINE phosphorylserine P-ser P-serine L-SOP O-Phospho-L-Serine,>95%(Ti) O-Phospho-L-serine Standard L O