4-CHLORO-6-FLUOROQUINAZOLINE
- CAS No.
- 16499-61-9
- Chemical Name:
- 4-CHLORO-6-FLUOROQUINAZOLINE
- Synonyms
- uoroquinazoL;4-CHLORO-6-FLUOROQUINAZOLINE;Quinazoline, 4-chloro-6-fluoro-;4-Chloro-6-fluoroquinazoline?New
- CBNumber:
- CB0456917
- Molecular Formula:
- C8H4ClFN2
- Molecular Weight:
- 182.58
- MDL Number:
- MFCD07776652
- MOL File:
- 16499-61-9.mol
| Product description | Number | Pack Size | Price |
| 4-Chloro-6-fluoroquinazoline | C384945 | 25mg | $45 |
| 4-Chloro-6-fluoroquinazoline | C384945 | 250mg | $155 |
| 4-Chloro-6-fluoroquinazoline | 3H44-7-07 | 250mg | $155 |
| 4-Chloro-6-fluoroquinazoline 90+% | 057317 | 1g | $79 |
| 4-Chloro-6-fluoroquinazoline | PC400552 | 1g | $276 |
| More product size | |||
| Boiling point | 284.9±20.0 °C(Predicted) |
|---|---|
| Density | 1.447±0.06 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| pka | 0.17±0.30(Predicted) |
| Appearance | Off-white to light yellow Solid |
| InChI | InChI=1S/C8H4ClFN2/c9-8-6-3-5(10)1-2-7(6)11-4-12-8/h1-4H |
| InChIKey | XIKGISGZFBCGDW-UHFFFAOYSA-N |
| SMILES | N1=C2C(C=C(F)C=C2)=C(Cl)N=C1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H302 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| HazardClass | IRRITANT |
| HS Code | 2933992000 |
4-CHLORO-6-FLUOROQUINAZOLINE price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | C384945 | 4-Chloro-6-fluoroquinazoline | 16499-61-9 | 25mg | $45 | 2021-12-16 | Buy |
| TRC | C384945 | 4-Chloro-6-fluoroquinazoline | 16499-61-9 | 250mg | $155 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H44-7-07 | 4-Chloro-6-fluoroquinazoline | 16499-61-9 | 250mg | $155 | 2021-12-16 | Buy |
| Matrix Scientific | 057317 | 4-Chloro-6-fluoroquinazoline 90+% | 16499-61-9 | 1g | $79 | 2021-12-16 | Buy |
| Apolloscientific | PC400552 | 4-Chloro-6-fluoroquinazoline | 16499-61-9 | 1g | $276 | 2021-12-16 | Buy |
4-CHLORO-6-FLUOROQUINAZOLINE Chemical Properties,Uses,Production
Synthesis
16499-56-2
16499-61-9
General procedure for the synthesis of 4-chloro-6-fluoroquinazoline from 6-fluoro-4-hydroxyquinazoline: a mixture of 6-fluoro-4-hydroxyquinazoline (1.64 g, 10 mmol) with phosphoryl chloride (7.5 mL, 50 mmol) and phosphorus pentachloride (6 g, 30 mmol) was heated and refluxed for 2 hours in a water bath. Upon completion of the reaction, the reaction mixture was cooled to room temperature and slowly poured into crushed ice to quench the reaction. The precipitated solid product was collected by filtration, washed well with water to remove residual acid and subsequently dried. The crude product was purified by column chromatography (eluent: hexane/ethyl acetate) to afford the target compound 4-chloro-6-fluoroquinazoline. Yield: 65%; Melting point: 140-142 °C; 1H-NMR (DMSO-d6, 300 MHz) δ 8.12 (s, 1H, ArH), 7.47 (dd, 1H, J = 7.9 Hz and 2.8 Hz, ArH), 7.53 (dd, 1H, J = 8.6 Hz and 5.1 Hz, ArH), 7.62 (s, 1H, ArH ); molecular formula: C8H4ClFN2 (molecular weight: 182); MS (ESI) m/z 183 [M + 1]+.
References
[1] Molecules, 2017, vol. 22, # 2,
[2] Patent: US5955464, 1999, A
[3] Organic Letters, 2010, vol. 12, # 3, p. 552 - 555
[4] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 21, p. 4885 - 4888
[5] Bioorganic Chemistry, 2018, vol. 80, p. 433 - 443
4-CHLORO-6-FLUOROQUINAZOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29734 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29850 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 | joe@yuhengpharm.com | CHINA | 21142 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Nanjing Hengbei Chemicals Co., Ltd. | +86-25-58393656 | sales@hengbeichem.cn | China | 6854 | 58 |
| Sichuan Biosynce Pharmatech Co., Ltd. | +8619950309693 | diane@biosynce.com | China | 4871 | 58 |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
View Lastest Price from 4-CHLORO-6-FLUOROQUINAZOLINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 4-CHLORO-6-FLUOROQUINAZOLINE
16499-61-9
|
US $1.00 / kg | 1kg | 98% | 200KG | Career Henan Chemical Co |
-
- 4-CHLORO-6-FLUOROQUINAZOLINE
16499-61-9
- US $1.00 / kg
- 98%
- Career Henan Chemical Co
16499-61-9(4-CHLORO-6-FLUOROQUINAZOLINE)Related Search:
1of4
