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Dimethoate

Description References
Dimethoate
Dimethoate structure
CAS No.
60-51-5
Chemical Name:
Dimethoate
Synonyms
FIP;Tara;USF2;CHAMP;CYGON;L 395;ROGOR;BI 58;bi-58;solut
CBNumber:
CB0459837
Molecular Formula:
C5H12NO3PS2
Formula Weight:
229.26
MOL File:
60-51-5.mol

Dimethoate Properties

Melting point:
52-52.5°C
Boiling point:
107°C (0.05 torr)
Density 
1.281
vapor pressure 
2.5 x 10-4 Pa (25 °C)
refractive index 
nD65 1.5334
Flash point:
107 °C
storage temp. 
0-6°C
form 
solid
pka
14.40±0.46(Predicted)
Water Solubility 
Slightly soluble. 2.5 g/100 mL
Merck 
13,3246
BRN 
1785339
CAS DataBase Reference
60-51-5(CAS DataBase Reference)
NIST Chemistry Reference
Dimethoate(60-51-5)
EPA Substance Registry System
Dimethoate (60-51-5)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H312
Precautionary statements  P280
Hazard Codes  Xn,T,F
Risk Statements  21/22-63-43-36/37/38-23/24/25-45-36-20/21/22-11-67-40
Safety Statements  2-36/37-24/25-23-53-26-16
RIDADR  UN 2783
WGK Germany  3
RTECS  TE1750000
HazardClass  6.1(b)
PackingGroup  III
HS Code  29309090
Toxicity LD50 orally in rats: 250 mg/kg (Schafer)

Dimethoate price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 45449 Dimethoate PESTANAL , analytical standard 60-51-5 100mg $96 2019-12-02 Buy
Sigma-Aldrich SAB1412650 ANTI-USF2 antibody produced in mouse clone 6A9, purified immunoglobulin, buffered aqueous solution 100ug $394 2019-12-02 Buy
Cayman Chemical 24246 Dimethoate ≥98% 60-51-5 50mg $25 2018-11-19 Buy
Cayman Chemical 24246 Dimethoate ≥98% 60-51-5 100mg $40 2018-11-19 Buy
Cayman Chemical 24246 Dimethoate ≥98% 60-51-5 250mg $94 2018-11-19 Buy

Dimethoate Chemical Properties,Uses,Production

Description

Dimethoate is a grey-white crystalline solid at room temperature. It is sparingly soluble in water, soluble in methanol and cyclohexane, but very soluble in chloroform and benzene. It has been classified by the U.S. EPA under GUP. Dimethoate is used extensively for the control of crop pests such as mites, aphids, thrips, plant hoppers, white-flies, and a wide range of other insects that damage, crops, fruits, vegetables, and ornamental plants. Dimethoate is also used for the control of cattle grubs that infect livestock. Thermal decomposition of dimethoate is highly hazardous due to the release of fumes of dimethylsulphide, methyl mercaptan, carbon monoxide, carbon dioxide, phosphorus pentoxide, and nitrogen oxides.

References

[1]Engenheiro, E. L., et al. "Influence of dimethoate on acetylcholinesterase activity and locomotor function in terrestrial isopods." Environmental Toxicology & Chemistry 24.3(2005):603.
[2]John, Susan, et al. "Protective effect of vitamin E in dimethoate and malathion induced oxidative stress in rat erythrocytes." The Journal of nutritional biochemistry 12.9 (2001): 500-504.
[3]Sharma, Yukti, et al. "Dimethoate-induced effects on antioxidant status of liver and brain of rats following subchronic exposure." Toxicology 215.3 (2005): 173-181.

Chemical Properties

Dimethoate is a gray-white crystalline solid at room temperature. It is sparingly soluble in water, soluble in methanol and cyclohexane, but very soluble in chloroform, benzene. It has been classifi ed by the US EPA under GUP. Dimethoate is used extensively for the control of crop pests, such as mites, aphids, thrips, plant-hoppers, white-fl ies, and a wide range of other insects that damage, crops, fruits, vegetables, and ornamental plants. Dimethoate is also used for the control of cattle grubs that infect livestock. Thermal decomposition of dimethoate is highly hazardous owing to the release of fumes of dimethylsulfi de, methyl mercaptane, carbon monoxide, carbon dioxide, phosphorus pentoxide, and nitrogenoxides.

Uses

An organophosphate insecticide. It is an anticholinesterase which disables cholinesterase, an enzyme essential for central nervous system function. Neurotoxic in humans.

Uses

insecticide, cholinesterase inhibitor

Uses

Systemic and contact organophosphorus insecticide and acaricide used to control thrips and red spider mites on many agricultural crops, saw?ies on apples and plums, wheat bulb and olive ?ies.

Uses

Dimethoate is used to control of a wide range of insect and mite pests in many crops. It is also used to control flies in animal houses.

Uses

Systemic and contact insecticide.

Definition

ChEBI: A monocarboxylic acid amide that is N-methylacetamide in which one of the hydrogens of the methyl group attached to the carbonyl moiety is replaced by a (dimethoxyphosphorothioyl)sulfanediyl group.

General Description

A white crystalline solid, with a camphor-like odor, white to grayish crystals for technical product. Dimethoate is a contact and systemic organophosphate insecticide effective against a broad range of insects and mites when applied on a wide range of crops. Dimethoate has not been produced in the U.S. since 1982.

Air & Water Reactions

Dimethoate is stable in aqueous solution but is hydrolyzed by aqueous alkali.

Reactivity Profile

Dimethoate is incompatible with alkaline preparations. Dimethoate is slightly corrosive to iron. Dimethoate is incompatible with sulfur based formulations. . Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Health Hazard

Very toxic; the probable oral lethal dose in humans is between 50-500 mg/kg, or between 1 teaspoon and 1 ounce for a 70 kg (150 lb.) person. Dimethoate is a cholinesterase inhibitor, meaning it affects the central nervous system. Death is due to respiratory arrest arising from failure of respiratory center, paralysis of respiratory muscles, intense bronchoconstriction or all three.

Health Hazard

Dimethoate is toxic to animals and humans. Occupational exposures cause poisoning with symptoms that include, but are not limited to, sweating, headache, weakness, giddiness, nausea, vomiting, stomach pains, blurred vision, pupillary constriction, slurred speech, and muscle twitching. Workers repeatedly exposed to dimethoate have shown symptoms of numbness, tingling sensations, incoordination, headache, dizziness, tremor, nausea, abdominal cramps, diffi culty breathing or respiratory depression, slow heart beat, and speech diffi culties. Prolonged exposures cause severe poisoning with adverse effects on the CNS, leading to incoordination, slurred speech, loss of refl exes, weakness, fatigue, involuntary muscle contractions, twitching, tremors of the tongue or eyelids, and eventually paralysis of the body extremities and the respiratory muscles, psychosis, irregular heart beats, unconsciousness, convulsions, coma, and death caused by respiratory failure or cardiac arrest.

Health Hazard

Cholinesterase inhibitor; very toxic, exhibit-ing acute, delayed, and chronic toxicity;routes of entry—ingestion, skin contact,and inhalation; toxic symptoms include nausea, vomiting, diarrhea, excessive salivation,bronchoconstriction, and respiratory arrest;oral intake of 5–20 g may cause death toadult humans.
LD50 oral (mammal): 15 mg/kg
The oral LD50 in rat, however, is higher(within the range 150 mg/kg) than someother common organophosphorus insecti-cides, such as Nemaphos, Mevinphos, orCoumaphos.

Fire Hazard

As with other organophosphorus pesticides, container may explode in heat of fire. The temperature of storage should not exceed 70-80F. Keep away from sources of heat, flames, or spark-generating equipment. Unstable in alkaline solution. Hydrolyzed by aqueous alkali. Stable in aqueous solutions. The compound is stable for 2 years under environmental conditions if stored in undamaged, original containers.

Agricultural Uses

Insecticide, Miticide: Dimethoate is used to kill mites and insects systemically and on contact. It is used against a wide range of insects, including aphids, thrips, planthoppers, and whiteflies on ornamental plants, alfalfa, apples, corn, cotton, grapefruit, grapes, lemons, melons, oranges, pears, pecans, safflower, sorghum, soybeans, tangerines, tobacco, tomatoes, watermelons, wheat, and other vegetables. It is also used as a residual wall spray in farm buildings for house flies. Dimethoate has been administered to livestock for control of botflies. Dimethoate is available in aerosol spray, dust, emulsifiable concentrate, and ULV concentrate formulations.

Trade name

REBELATE®; CEKUTHOATE®; CHIMIGOR 40®; CYGON 400®[C]; DEFEND®; DAPHENE®; DANADIM®; DANADIM® PROGRESS; DE-FEND®; DEMOS NF®; DEVIGON®; DICAP®; DIMATE 267®; DIMET®; DIMETHOATE 40; DIMETHOPGAN®; FERKETHION®; FOSTION MM®; KENLOGO®; NUGOR®; PERFEKTION®; ROGODAN®; ROGODIAL®; ROGOR®; ROXION®; SEVIGOR®

Contact allergens

This organophosphorus compound is used as a contact and systemic insecticide and acaricide. It induced an erythema-multiform-like contact dermatitis in a ware- houseman in an agricultural consortium.

Safety Profile

A deadly human poison. Poison by ingestion, skin contact, intraperitoneal, and subcutaneous routes. Moderately toxic by intravenous route. Human systemic effects: coma, dyspnea,fasciculations. Questionable carcinogen with experimental carcinogenic data. Experimental teratogenic and reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx、, POx, and SOx. See also ESTERS.

Carcinogenicity

Rats given diets with 0, 5, 25, or 100 ppm dimethoate (0, 0.25, 1.25, or 5 mg/kg/day) for 2 years showed dose-related trends for spleen hemangiosarcoma; combined spleen hemangioma and hemangiosarcoma; and combined spleen hemangioma, hemangiosarcoma, and skin hemangiosarcoma . There were also significant differences in pair-wise comparisons between controls and low-dose (0.25 mg/kg) or high-dose (5 mg/kg) groups for spleen (hemangioma/hemangiosarcoma) and combined tumors of spleen and skin hemangiosarcoma and lymph angioma/angiosarcoma; and between low and high doses for all tumors combined.

Environmental Fate

Soil. Duff and Menzer (1973) reported that in moist soils, dimethoate is converted to the oxygen analog, dimethoate carboxylic acid (dimethoxon) and two unidentified metabolites. The degradation rate of dimethoate in three different soils increased almost twofold with a 10°C increase in temperature (Kolbe et al., 1991). The reported half-lives of dimethoate in a humus-rich sandy soil, clay loam and heavy clay soil at 10 and 20°C are 15.3, 10.3, 15.5 days and 9.7, 4.8 and 8.5 days, respectively. Degradates included dimethoxon (O,O-dimethyl-S-(N-methylcarbamoylmethyl)phosphorothiolate) and unidentified polar compounds (Kolbe et al., 1991).
In a silt loam and sandy loam, reported Rf values were 0.42 and 0.45, respectively (Sharma et al., 1986).
Plant. In plants, oxidation/hydrolysis leads to the formation of the phosphorothioate. Other hydrolysis products in plants include O,O-dimethylphosphorodithioate and O,Odimethylphosphorophosphate which occurs via demethylation and hydrolytic clea
The half-life in Bermuda grass was reported to be 3.1 days (Beck et al., 1966). The disappearance half-lives of dimethoate on bean, tomato, cucumber and cotton plants were 4.3, 6.0, 3.8 and 3.3 days, respectively (Belal and Gomaa, 1979).
Surface Water. Though no products were identified, the half-life in raw river water was 8 weeks (Eichelberger and Lichtenberg, 1971). Photolytic. Dichlorvos should not undergo direct photolysis since it does not absorb UV light at wavele

Metabolic pathway

Dimethoate is a systemic insecticide which is rapidly translocated to all parts of the plant. Metabolism to omethoate (dimethoate oxon), the active cholinesterase inhibitor, is a major pathway in both animals and plants. Degradative metabolism is either via dealkylation to yield both des-O- methyldimethoate and des-O-methylomethoate, followed by hydrolysis or dealkylation to give mono- and di-methyl phosphate, phosphorothioate and phosphorodithioate esters which are ultimately degraded to phosphate. An additional mechanism is through hydrolysis of the amide group to give dimethoate and omethoate carboxylic acids. An important additional metabolic pathway is oxidative N-demethylation of dimethoate and omethoate to give des-N-methyldimethoate and des-N-methy lomethoate via their respective N-hydroxymethyl derivatives. It is possible that the N-demethylation route could precede amidase action leading to dimethoate and omethoate carboxylic acids which are excreted in mammals. The 'thioglycolate' part of the molecule is metabolised to α-hydroxy-N-methylacetamide in mammals.

Degradation

Dimethoate is stable in aqueous media in the pH range 2-7 but hydrolysed under alkaline conditions (PM). Under acidic conditions the sole product of hydrolysis is desmethyldimethoate (2), whereas in alkali both desmethyldimethoate (2) and O,O-dimethylphosphorothioate (3) were formed. These products are in accord with other studies on the effects of pH on the hydrolysis of phospho-triesters, with dealkylation predominating under acidic conditions and SN2 attack on phosphorus by OH- at high pH (PSD, 1993).
Dimethoate is stable to photolysis. In an experiment to measure the degradation of an aqueous solution of dimethoate, a sample of [O-14C-methyl]dimethoate was irradiated with a xenon arc lamp for 15 days. The compound was extracted unchanged (93.4%) and no specific degradation products were identified (PSD, 1993).

Dimethoate Preparation Products And Raw materials

Raw materials

Preparation Products


Dimethoate Suppliers

Global( 166)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32447 55
career henan chemical co
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sales@coreychem.com CHINA 29996 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23981 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 8835 58
QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8407 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 sales@guangaobio.com CHINA 23049 58
Shandong chuangyingchemical Co., Ltd.
13156170209
sale@chuangyingchem.com CHINA 4405 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20115 58
Chongqing Chemdad Co., Ltd
+86-13650506873
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View Lastest Price from Dimethoate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-21 Dimethoate
60-51-5
US $7.00 / KG 1KG 99% 1000KG career henan chemical co

Dimethoate Spectrum


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