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Nystatin

Nystatin
Nystatin structure
CAS No.
1400-61-9
Chemical Name:
Nystatin
Synonyms
nystan;Nystex;Nystop;MORONAL;nilstat;Nyotran;Nystain;NYSTATIN;biofanal;stamycin
CBNumber:
CB0463474
Molecular Formula:
C47H75NO17
Formula Weight:
926.09
MOL File:
1400-61-9.mol

Nystatin Properties

Melting point:
>155°C (dec.)
alpha 
D25 -10° (glacial acetic acid); +21° (pyridine); +12° (DMF); -7° (0.1N HCl in methanol)
storage temp. 
−20°C
solubility 
H2O: insoluble
form 
suspension
pka
pKa 5.72(MeOH/2-methoxyethanol/ H2O) (Uncertain);8.64 (Uncertain)
color 
yellow
Merck 
13,6770
InChIKey
VXWFKTGGEJLHPP-OQMKPJEFSA-N
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  F,C
Risk Statements  11-34
Safety Statements  22-24/25-45-36/37/39-26-16
WGK Germany  3
RTECS  RF5950000
10-8-23
HazardClass  3
HS Code  38210000
Hazardous Substances Data 1400-61-9(Hazardous Substances Data)
Toxicity LD50 i.p. in mice: ~200 mg/kg (Seneca)
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H331 Toxic if inhaled Acute toxicity,inhalation Category 3 Danger P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P405 Store locked up.

Nystatin price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 475914 Nystatin 1400-61-9 1gm $53.6 2018-11-20 Buy
Sigma-Aldrich 1477003 Nystatin United States Pharmacopeia (USP) Reference Standard 1400-61-9 200mg $357.7 2018-11-20 Buy
Alfa Aesar J62486 Nystatin 1400-61-9 10g $99.3 2018-11-13 Buy
Alfa Aesar J62486 Nystatin 1400-61-9 5g $55.2 2018-11-13 Buy
Sigma-Aldrich N6261 Nystatin powder, BioReagent, suitable for cell culture 1400-61-9 5mu $58.2 2018-11-20 Buy

Nystatin Chemical Properties,Uses,Production

Chemical Properties

Brown Solid

Uses

Antifungal;Performs membrane ionophores

Uses

Nystatin is polyene antifungal containing a conjugated tetraene and a diene, isolated as a complex of three components A1, A2 and A3 from Streptomyces noursei and first reported in 1950. Nystatin, like most polyene antifungals, binds to sterols in the fungal cell membrane leading to formation of ion channels in the wall, ion imbalance and cell death. Nystatin is an established bioprobe and widely-used antifungal reagent with over 4,000 literature citations.

Uses

Polyene antifungal antibiotic complex containing 3 biologically active components, A1, A2, A3. Increases the permeability of the cell membrane of sensitive fungi by binding to sterols. Cell culture tested. Growth promotant. Nystatin A1 is shown.

Definition

ChEBI: A polyene macrolide antibiotic; part of the nystatin complex produced by several Streptococcus species. The keto-form of nystatin A1.

brand name

Barstatin 100 (Barlan); Candex (Bayer); Korostatin (Holland Rantos); Mycostatin (Bristol-Myers Squibb); Mycostatin (Westwood-Squibb).

General Description

Nystatin (Mycostatin) is a polyene antibiotic that was first isolated in 1951 from a strain of the actinomycete Streptomyces noursei by Hazen and Brown.33 It occurs as a yellow to light tan powder. Nystatin is very slightly soluble in water and sparingly soluble in organic solvents. The compound is unstable to moisture, heat, and light. The aglycone portion of nystatin is called nystatinolide. The complete structure of nystatin has been determined by chemical degradation and x-ray crystallography.35 Nystatin is not absorbed systemically when administered by the oral route. It is nearly insoluble under all conditions. It is also too toxic to be administered parenterally. Hence, it is used only as a topical agent. Nystatin is a valuable agent for the treatment of local and gastrointestinal monilial infections caused by C. albicans and other Candida species. For the treatment of cutaneous and mucocutaneous candidiasis, it is supplied as a cream, an ointment, and a powder. Vaginal tablets are available for the control of vaginal candidiasis. Oral tablets and troches are used in the treatment of gastrointestinal and oral candidiasis. Combinations of nystatin with tetracycline can be used to prevent monilial overgrowth caused by the destruction of bacterial microflora of the intestine during tetracycline therapy.

Safety Profile

Poison by intraperitoneal and intravenous routes. Moderately toxic by subcutaneous route. Mildly toxic by ingestion. An experimental teratogen. Mutation data reported. An antibiotic. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Nystatin is a light yellow powder with the following solubilities at ~28o: MeOH (1.1%), ethylene glycol (0.9%), H2O (0.4%), CCl4 (0.12%), EtOH (0.12%), CHCl3 (0.05%) and *C6H6 (0.03%). It has been precipitated from MeOH solution by addition of H2O. Aqueous suspensions of this macrolide antifungal antibiotic are stable at 100o/10minutes at pH 7.0 but decompose rapidly at pH <2 and >9, and in the presence of light and O2. [Birch et al. Tetrahedron Lett 1491, 1485 1964, Weiss et al. Antibiot Chemother 7 374 1957.] It may contain a mixture of components A1, A2 and A3. [Beilstein 18 III/IV 7480.]

Nystatin Preparation Products And Raw materials

Raw materials

Preparation Products


Nystatin Suppliers

Global( 248)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 2461 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682; +8618874586545
02783214688 bruce@xrdchem.cn CHINA 552 55
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 308 58
Chemwill Asia Co.,Ltd.
86-21-51086038
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Hubei Jusheng Technology Co.,Ltd.
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QUALITY CONTROL CHEMICALS INC.
(323) 306-3136
(626) 453-0409 orders@qcchemical.com United States 8430 58
Zhejiang ZETian Fine Chemicals Co. LTD
+86-18957127338
sales@zetchem.com CHINA 1583 58
Hebei Huanhao Biotechnology Co., Ltd.
86-0311-83975816
86-0311-83975816 grace@hbhuanhao.com CHINA 681 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 19997 58
Foshan Haizheng Pharmaceutical Co., Ltd. 13360369168、0757-22808153
0757-22803019 info@hyzonpharm.com China 1 58

View Lastest Price from Nystatin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-08-20 Nystatin
1400-61-9
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-11-30 Nystatin
1400-61-9
US $20.00 / KG 1KG 99% 20ton Hebei Huanhao Biotechnology Co., Ltd.

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