ChemicalBook >> CAS DataBase List >>AZD3229
AZD3229
- CAS No.
- 2248003-60-1
- Chemical Name:
- AZD3229
- Synonyms
- AZD3229;AZD3229 (AZD-3229;AZD3229;AZD 3229;AZD-3229;Inhibitor,AZD3229,CD117,AZD 3229,AZD-3229,SCFR,c-Kit,inhibit;1H-1,2,3-Triazole-1-acetamide, N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-
- CBNumber:
- CB04667591
- Molecular Formula:
- C24H26FN7O3
- Molecular Weight:
- 479.51
- MDL Number:
- MOL File:
- 2248003-60-1.mol
Last updated:2023-09-20 16:43:00
| Density | 1.35±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | Store at -20°C |
| solubility |
DMSO:68.67(Max Conc. mg/mL);143.21(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);20.85(Max Conc. mM) Ethanol:0.3(Max Conc. mg/mL);0.63(Max Conc. mM) |
| form | A crystalline solid |
| pka | 12.75±0.70(Predicted) |
| FDA UNII | 9ZGC48P3RV |
AZD3229 price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27908 | AZD 3229 | 2248003-60-1 | 500μg | $68 | 2024-03-01 | Buy |
| Cayman Chemical | 27908 | AZD 3229 | 2248003-60-1 | 5mg | $286 | 2024-03-01 | Buy |
| Cayman Chemical | 27908 | AZD 3229 | 2248003-60-1 | 1mg | $130 | 2024-03-01 | Buy |
| ChemScene | CS-0065717 | AZD3229 99.55% | 2248003-60-1 | 5mg | $220 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb573321 | AZD3229 >98% | 2248003-60-1 | 250mg | $1949.9 | 2021-12-16 | Buy |
AZD3229 Chemical Properties,Uses,Production
Biological Activity
AZD3229 is a potent pan-Kit (c-Kit) mutant inhibitor with GI50 of 1-50 nM in a Kit (c-Kit) mutant-driven Ba/F3 cell line. It also inhibits PDGFR mutants (Tel-PDGFRα, Tel-PDGFRβ, V561D/D842V).
in vivo
AZD3229 has high bioavailability, low clearance and small volume of distribution in preclinical animal models of mice, rats and dogs. In an in vivo model constructed using the Ba/F3 cell line, AZD3229 at 20 mg/kg bid induces regression of tumor volume more effectively than regorafenib and imatinib at 100 mg/kg qd.
target
| Target | Value |
| Kit () | |
| PDGFRα () | |
| PDGFRβ () |
AZD3229 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 20)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 359 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1977 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
AZD3229
AZD3229
(AZD-3229
AZD3229;AZD 3229;AZD-3229
Inhibitor,AZD3229,CD117,AZD 3229,AZD-3229,SCFR,c-Kit,inhibit
1H-1,2,3-Triazole-1-acetamide, N-[4-[[5-fluoro-7-(2-methoxyethoxy)-4-quinazolinyl]amino]phenyl]-4-(1-methylethyl)-
2248003-60-1