PF-06761281
- CAS No.
- 1854061-19-0
- Chemical Name:
- PF-06761281
- Synonyms
- PF-06761281;PF-06761281 >=97% (HPLC);Butanedioic acid, 2-hydroxy-2-[2-(2-methoxy-5-methyl-3-pyridinyl)ethyl]-, (2R)-
- CBNumber:
- CB04670535
- Molecular Formula:
- C13H17NO6
- Molecular Weight:
- 283.28
- MDL Number:
- MOL File:
- 1854061-19-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P330+P331+P310 |
| RIDADR | UN 2811 6.1 / PGIII |
PF-06761281 price More Price(2)
PF-06761281 Chemical Properties,Uses,Production
Uses
PF-06761281 has been used as a SLC13A family inhibitor, in rats to determine its unbound partition coefficient (Kpuu), to estimate its potency as a drug.
General Description
PF-06761281 is a small, polar dicarboxylate compound. Its structure is similar to citrate, which is the endogenous substrate of Na+-citrate cotransporter (NaCT). It is a novel, potent inhibitor of SLC13a2/3/5 (solute channel) family, along with selectivity for NaCT.
Biochem/physiol Actions
PF-06761281 is an inhibitor of the sodium-coupled citrate transporter (NaCT or SLC13A5), which may be a target for tretment and prevention of metabolic disorders. The SLC13 transporters SLC13A2 (NaDC1), SLC13A3 (NaDC3), and SLC13A5 (NaCT) co-transport di- and tricarboxylates with multiple sodium ions into cells. PF-06761281 inhibits citrate uptake with an IC50 of 740 nM for NaCT in human hepatocytes. PF-06761281 has >25-fold in vitro selectivity for NaCT over NaDC1 and NaDC3 and was inactive in a selectivity panel of 65 targets.
PF-06761281 Preparation Products And Raw materials
Raw materials
Preparation Products
PF-06761281 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9414 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44894 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1249 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |
| DC Chemicals | 58 |
| Energy Chemical | 58 |
| Beijing Biocreative Technology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |