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1-METHYL-D-TRYPTOPHAN

1-METHYL-D-TRYPTOPHAN
1-METHYL-D-TRYPTOPHAN structure
CAS No.
110117-83-4
Chemical Name:
1-METHYL-D-TRYPTOPHAN
Synonyms
Me-D-Trp;NLG-8189;IndoxiMod;1-Me-D-Trp;D-Trp(Me)-OH;H-D-Trp(1-Me)-OH;Indoximod (NLG-8189);1-METHYL-D-TRYPTOPHAN;1-Methyl-D-tryptophane;1-METHYL-D-TRYPTOPHAN 95%
CBNumber:
CB0467553
Molecular Formula:
C12H14N2O2
Formula Weight:
218.25
MOL File:
110117-83-4.mol

1-METHYL-D-TRYPTOPHAN Properties

Melting point:
242-245 °C(lit.)
alpha 
12.4o (C = 2 IN ACETIC ACID)
Density 
1.28
form 
White to light brown crystalline powder.
optical activity
[α]22/D +12.4°, c = 2 in acetic acid
InChIKey
ZADWXFSZEAPBJS-SNVBAGLBSA-N
SAFETY
  • Risk and Safety Statements
WGK Germany  3

1-METHYL-D-TRYPTOPHAN price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 452483 1-Methyl-D-tryptophan 95% 110117-83-4 1g $105 2018-11-13 Buy
Sigma-Aldrich 452483 1-Methyl-D-tryptophan 95% 110117-83-4 10g $745 2018-11-13 Buy
Cayman Chemical 16456 1-methyl-D-Tryptophan ≥95% 110117-83-4 5g $389 2018-11-13 Buy
Cayman Chemical 16456 1-methyl-D-Tryptophan ≥95% 110117-83-4 1g $93 2018-11-13 Buy
Sigma-Aldrich 452483 1-Methyl-D-tryptophan 95% 110117-83-4 250mg $33.4 2018-11-13 Buy

1-METHYL-D-TRYPTOPHAN Chemical Properties,Uses,Production

Uses

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo. 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 μM) that is effective in vivo. In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO. It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO. 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival. Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.

1-METHYL-D-TRYPTOPHAN Preparation Products And Raw materials

Raw materials

Preparation Products


1-METHYL-D-TRYPTOPHAN Suppliers

Global( 97)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
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+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
ATK CHEMICAL COMPANY LIMITED
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BOC Sciences
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Alchem Pharmtech,Inc.
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Binhai gill polypeptide co. LTD 021-61263389;13524856427
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Shanghai Boyle Chemical Co., Ltd.
86-21-57758967 sales@boylechem.com China 2926 55
Energy Chemical 021-58432009 / 400-005-6266
021-58436166-800 info@energy-chemical.com China 44025 61

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