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Isorhamnetin

Description References
Isorhamnetin
Isorhamnetin structure
CAS No.
480-19-3
Chemical Name:
Isorhamnetin
Synonyms
c.i.75680;ISOHAMNETIN;sorhamnetin;Isorhanetin;ISORHAMNETIN;isorhamnetol;3-METHYLQUERCETIN;ISORHAMNETIN hplc;3’-methoxyquercetin;Isorhamnetin (15 mg)
CBNumber:
CB0472359
Molecular Formula:
C16H12O7
Formula Weight:
316.26
MOL File:
480-19-3.mol

Isorhamnetin Properties

Melting point:
307°C
Boiling point:
599.4±50.0 °C(Predicted)
Density 
1.634±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
6.31±0.40(Predicted)
form 
neat
BRN 
44723
InChIKey
IZQSVPBOUDKVDZ-UHFFFAOYSA-N
CAS DataBase Reference
480-19-3(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
07X3IB4R4Z
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H351
Precautionary statements  P281-P280
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-40
Safety Statements  22-36-26-36/37
WGK Germany  3
RTECS  LK9275450
HS Code  29329990

Isorhamnetin price More Price(12)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 17794 Isorhamnetin ≥95.0% (HPLC) 480-19-3 5mg $146 2020-08-18 Buy
Sigma-Aldrich PHL89314 Isorhamnetin phyproof? Reference Substance 480-19-3 20 mg $410 2021-03-22 Buy
Sigma-Aldrich 04290585 Isorhamnetin primary pharmaceutical reference standard 480-19-3 10mg $626 2021-03-22 Buy
TCI Chemical I1068 Isorhamnetin 480-19-3 50MG $280 2021-03-22 Buy
TCI Chemical I1068 Isorhamnetin 480-19-3 10MG $80 2021-03-22 Buy

Isorhamnetin Chemical Properties,Uses,Production

Description

Isorhamnetin is a flavonoid, which occurs naturally in plants and it is also a metabolite of quercetin.
Isorhamnetin has anti-inflammatory effect as it can reduce the formation of large amounts of nitric oxide by the inhibition the activation of nuclear factor-κB (NF-κB), which is a significant transcription factor for inducible nitric oxide synthase.  Isorhamnetin is also reported to have effect in inducing the expression of neurofilaments, and it potentiated the NGF-induced neurite outgrowth and neurofilament expression, which could be a new direction in searching potential candidates as new drugs or food supplements for neurodegenerative diseases.

References

[1] Mari Hämäläinen, Riina Nieminen, Pia Vuorela, Marina Heinonen and Eeva Moilanen, Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages, Mediators of Inflammation, 2007, vol. 2007, Article ID 45673
[2] Sherry L. Xu, Roy C. Y. Choi, Kevin Y. Zhu, Ka-Wing Leung, Ava J. Y. Guo, Dan Bi, Hong Xu, David T. W. Lau, Tina T. X. Dong and Karl W. K. Tsim, Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor, Evidence-Based Complementary and Alternative Medicine, 2012, vol. 2012, Article ID 278273

Chemical Properties

Beige to lighet yellow powder

Uses

A metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

Uses

Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin . It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 μM). Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 μM), which has an important role in the excretion of xenobiotics at the kidney and liver. It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.

Definition

ChEBI: A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.

Isorhamnetin Preparation Products And Raw materials

Raw materials

Preparation Products


Isorhamnetin Suppliers

Global( 263)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
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sales@coreychem.com CHINA 29954 58
Chengdu GLP biotechnology Co Ltd
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Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
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Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
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BOC Sciences
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Chongqing Chemdad Co., Ltd
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Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58

View Lastest Price from Isorhamnetin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-17 Isorhamnetin 480-19-3
480-19-3
US $20.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-08-12 Isorhamnetin
480-19-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd
2021-07-13 Isorhamnetin
480-19-3
US $15.00-10.00 / KG 1KG 99%+ HPLC Monthly supply of 1 ton Zhuozhou Wenxi import and Export Co., Ltd

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