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Isorhamnetin

Description References
Isorhamnetin
Isorhamnetin
CAS No.
480-19-3
Chemical Name:
Isorhamnetin
Synonyms
c.i.75680;ISOHAMNETIN;Isorhanetin;ISORHAMNETIN;isorhamnetol;3-METHYLQUERCETIN;ISORHAMNETIN hplc;3’-methoxyquercetin;Isorhamnetin (15 mg);ISORHAMNETIN WITH HPLC
CBNumber:
CB0472359
Molecular Formula:
C16H12O7
Formula Weight:
316.26
MOL File:
480-19-3.mol

Isorhamnetin Properties

Melting point:
307°C
storage temp. 
2-8°C
CAS DataBase Reference
480-19-3(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-40
Safety Statements  22-36-26-36/37
RTECS  LK9275450
HS Code  29329990
Symbol(GHS):
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H351 Suspected of causing cancer Carcinogenicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.

Isorhamnetin price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1351800 Isorhamnetin United States Pharmacopeia (USP) Reference Standard 480-19-3 15mg $333.3 2017-11-08 Buy
Sigma-Aldrich 04290585 Isorhamnetin primary pharmaceutical reference standard 480-19-3 10mg $541 2017-11-08 Buy
Cayman Chemical 16496 Isorhamnetin ≥98% 480-19-3 1mg $40 2018-11-13 Buy
Cayman Chemical 16496 Isorhamnetin ≥98% 480-19-3 5mg $78 2018-11-13 Buy
Sigma-Aldrich 17794 Isorhamnetin ≥95.0% (HPLC) 480-19-3 5mg $134 2017-11-08 Buy

Isorhamnetin Chemical Properties,Uses,Production

Description

Isorhamnetin is a flavonoid, which occurs naturally in plants and it is also a metabolite of quercetin.
Isorhamnetin has anti-inflammatory effect as it can reduce the formation of large amounts of nitric oxide by the inhibition the activation of nuclear factor-κB (NF-κB), which is a significant transcription factor for inducible nitric oxide synthase.  Isorhamnetin is also reported to have effect in inducing the expression of neurofilaments, and it potentiated the NGF-induced neurite outgrowth and neurofilament expression, which could be a new direction in searching potential candidates as new drugs or food supplements for neurodegenerative diseases.

References

[1] Mari Hämäläinen, Riina Nieminen, Pia Vuorela, Marina Heinonen and Eeva Moilanen, Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages, Mediators of Inflammation, 2007, vol. 2007, Article ID 45673
[2] Sherry L. Xu, Roy C. Y. Choi, Kevin Y. Zhu, Ka-Wing Leung, Ava J. Y. Guo, Dan Bi, Hong Xu, David T. W. Lau, Tina T. X. Dong and Karl W. K. Tsim, Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor, Evidence-Based Complementary and Alternative Medicine, 2012, vol. 2012, Article ID 278273

Chemical Properties

Beige to lighet yellow powder

Uses

A metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

Definition

ChEBI: A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.

Uses

Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin . It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 μM). Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 μM), which has an important role in the excretion of xenobiotics at the kidney and liver. It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.

Isorhamnetin Preparation Products And Raw materials

Raw materials

Preparation Products


Isorhamnetin Suppliers

Global( 164)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Chengdu GLP Biotech Co., Ltd
13350802083
scglp@glp-china.com CHINA 1000 58
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3625 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 10011 58
Chengdu Biopurify Phytochemicals Ltd. 86-28-82633397
+86-28-82633165 sales@biopurify.com China 2011 60
Shanghai Boyle Chemical Co., Ltd. 86-15221043597
86-21-57758967 sales@boylechem.com China 2898 55
J & K SCIENTIFIC LTD. 400-666-7788 +86-10-82848833
+86-10-82849933 jkinfo@jkchemical.com;market6@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
86-21-50328109 3bsc@sina.com China 15940 69
Chembest Research Laboratories Limited +86(0)21-20908456
+86(0)21-58180499 sales@biochembest.com; market@biochembest.com China 6070 61
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15709 60

View Lastest Price from Isorhamnetin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-07-30 Isorhamnetin
480-19-3
US $480.00 / KG 10KG 95% 1000kg

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