Isorhamnetin | 480-19-3

Isorhamnetin Properties

Melting point	307°C
Boiling point	599.4±50.0 °C(Predicted)
Density	1.634±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
pka	6.31±0.40(Predicted)
color	Light yellow to Amber to Dark green
BRN	44723
Stability	Hygroscopic
InChIKey	IZQSVPBOUDKVDZ-UHFFFAOYSA-N
LogP	1.760 (est)
CAS DataBase Reference	480-19-3(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	07X3IB4R4Z

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H351
Precautionary statements	P281-P280
Hazard Codes	Xi,Xn
Risk Statements	36/37/38-40
Safety Statements	22-36-26-36/37
WGK Germany	3
RTECS	LK9275450
HS Code	29329990

Isorhamnetin price More Price(64)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHL89314	Isorhamnetin phyproof? Reference Substance	480-19-3	20mg	$528	2024-03-01	Buy
Sigma-Aldrich	17794	Isorhamnetin ≥95.0% (HPLC)	480-19-3	5mg	$186	2024-03-01	Buy
TCI Chemical	I1068	Isorhamnetin	480-19-3	10MG	$97	2024-03-01	Buy
TCI Chemical	I1068	Isorhamnetin	480-19-3	50MG	$339	2024-03-01	Buy
Cayman Chemical	16496	Isorhamnetin ≥98%	480-19-3	1mg	$50	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHL89314	20mg	$528	Buy
17794	5mg	$186	Buy
I1068	10MG	$97	Buy
I1068	50MG	$339	Buy
16496	1mg	$50	Buy

Isorhamnetin Chemical Properties,Uses,Production

Description

Isorhamnetin is a flavonoid, which occurs naturally in plants and it is also a metabolite of quercetin.
Isorhamnetin has anti-inflammatory effect as it can reduce the formation of large amounts of nitric oxide by the inhibition the activation of nuclear factor-κB (NF-κB), which is a significant transcription factor for inducible nitric oxide synthase. Isorhamnetin is also reported to have effect in inducing the expression of neurofilaments, and it potentiated the NGF-induced neurite outgrowth and neurofilament expression, which could be a new direction in searching potential candidates as new drugs or food supplements for neurodegenerative diseases.

References

[1] Mari Hämäläinen, Riina Nieminen, Pia Vuorela, Marina Heinonen and Eeva Moilanen, Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages, Mediators of Inflammation, 2007, vol. 2007, Article ID 45673
[2] Sherry L. Xu, Roy C. Y. Choi, Kevin Y. Zhu, Ka-Wing Leung, Ava J. Y. Guo, Dan Bi, Hong Xu, David T. W. Lau, Tina T. X. Dong and Karl W. K. Tsim, Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor, Evidence-Based Complementary and Alternative Medicine, 2012, vol. 2012, Article ID 278273

Chemical Properties

Beige to lighet yellow powder

Uses

Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin . It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 μM). Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 μM), which has an important role in the excretion of xenobiotics at the kidney and liver. It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.

Definition

ChEBI: Isorhamnetin is a monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor, an anticoagulant and a metabolite. It is a 7-hydroxyflavonol, a tetrahydroxyflavone and a monomethoxyflavone. It derives from a quercetin. It is a conjugate acid of an isorhamnetin(1-).

Application

Isorhamnetin is a metabolite of the flavanoid Quercetin with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

benefits

Isorhamnetin may have potential benefits in inhibiting the onset and treatment of neuroinflammatory diseases. Isorhamnetin is not that much studied than quercetin. However, the few that exist indicate that isorhamnetin has similar health benefits: it may reduce the risk of cancer, improve heart health and ease diabetes complications.

General Description

Isorhamnetin is one of the important flavanols found in G.biloba leaf extracts. Isorhamnetin is also found in parsley, and thereby it is a common dietary flavonoid as the metabolite of quercetin.Generally, it is well known as antagonist of peroxisome proliferator-activated receptor Y (PPARy), which inhibits adipocyte differentiation induced by the PPARy agonist rosiglitazone. Isorhamnetin is a naturally occurring compound in fruits and vegetables; recent study showed that isorhamnetin could significantly inhibit the invasion of MDA-MB-231 cells by downregulating matrix metalloproteinases(MMP-2 and MMP-9) through inhibiting p38 MAPK and STAT3. Similar results were also obtained in another study, which showed that isorhamnetin inhibited cell proliferation and led to apoptosis. In addition, isorhamnetin was found effective on Akt/mTOR/MAPKs signaling axis. It was established that isorhamnetin-induced autophagy can be reversed by the co-treatment of 3-methyl-adenine in lung cancer cells. The results indicated that isorhamnetin exerts antitumor effect in breast cancer through targeting multiple molecular targets.

Biochem/physiol Actions

Isorhamnetin inhibits adipogenesis by interfering with differentiation of adipose stem cells, by a mechanism involving stabilization of β-catenin and up-regulating the Wnt signaling pathway.

Isorhamnetin synthesis

Synthesis of Isorhamnetin from 2-Propen-1-one, 3-(4-hydroxy-3-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, (2E)-

Isorhamnetin Preparation Products And Raw materials

Raw materials

2-Propen-1-one, 3-(4-hydroxy-3-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)-, (2E)- 1-(2-hydroxy-4,6-bis(methoxymethoxy)phenyl)ethanone Vanillin

Preparation Products

Isorhamnetin Suppliers

Global( 338)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Jiangsu Yongjian Pharmaceutical Co.,Ltd	+86-0523-80183620 +86-17701422015	982552664@qq.com	China	258	58
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	qinhe02@xaltbio.com	China	1000	58
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Chengdu Greenpure Biopharma CO.,Ltd	18283602253	jancyzheng@gcgreenpure.com	China	952	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	scglp@glp-china.com	CHINA	1824	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	7838	58
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58

Supplier	Advantage
Jiangsu Yongjian Pharmaceutical Co.,Ltd	58
Shaanxi Haibo Biotechnology Co., Ltd	58
Shanghai Zheyan Biotech Co., Ltd.	58
Chengdu Greenpure Biopharma CO.,Ltd	58
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	58

View Lastest Price from Isorhamnetin manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-12	Isorhamnetin 480-19-3	US $0.00 / kg	1kg	99%	2000ton	Shaanxi Haibo Biotechnology Co., Ltd
2023-11-30	Isorhamnetin 480-19-3	US $1100.00-1000.00 / KG	1KG	24%	800KGs	ZhenYiBio Technology Inc
2023-08-08	Isorhamnetin 480-19-3	US $0.00-0.00 / kg	1kg	0.99	50000kg	Hebei Yibangte Import and Export Co. , Ltd.

Isorhamnetin
480-19-3
US $0.00 / kg
99%
Shaanxi Haibo Biotechnology Co., Ltd

Isorhamnetin
480-19-3
US $1100.00-1000.00 / KG
24%
ZhenYiBio Technology Inc

Isorhamnetin
480-19-3
US $0.00-0.00 / kg
0.99
Hebei Yibangte Import and Export Co. , Ltd.

Isorhamnetin Spectrum

Isorhamnetin(480-19-3)¹HNMR

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2'-Hydroxyacetophenone DIPHENYLCYCLOPROPENONE α-L-Rhamnopyranose monohydrate 4-Methoxyphenylacetone ISORHAMNETIN 3-O-NEOHESPEROSIDE

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Isoimperatorin Isosorbide ISOSTEVIOL

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IsorhaMnetin, froM Hippophae fhaMnoides L. sorhamnetin 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)- 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-one 3'-Methoxy-3,4',5,7-tetrahydroxyflavone 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one 3'-METHOXY-3,4',5,7-TETRAHYDROXYFLAVONE 3'-METHOXY-3,5,7,4'-TETRAHYDROXYFLAVONE 3,5,7,4'-TETRAHYDROXY-3'-METHOXYFLAVONE 3,5,7-TRIHYDROXY-2-(4-HYDROXY-3-METHOXYPHENYL)-4-BENZOPYRONE 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-1-benzopyran-4-one 3,5,7-trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on ISORHAMNETIN 2-(3-methoxy-4-hydroxyphenyl)-3,5,7-trihydroxy-4h-1-benzopyran-4-on 3,4’,5,7-tetrahydroxy-3’-methoxy-flavon 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4h-1-benzopyran-4-on 3’-methoxy-3,4’,5,7-tetrahydroxy-flavon 3’-methoxyquercetin c.i.75680 isorhamnetol I3,6,7-TRIHYDROXY-2-(4-HYDROXY-3-METHOXYPHENYL)-4H-CHROMEN-4-ONE ISORHAMNETIN WITH HPLC Flavone, 3,4',5,7-tetrahydroxy-3'-methoxy- 3'-Methoxy-3,4',5,7-tetrahydroxyflavone 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on Isorhanetin ISOHAMNETIN:3'-METHOXY-3,4',5,7-TETRAHYDRO-XY-FLAVONE QUERCETIN-3-ORTHO-METHYLETHER ISORHAMNETIN hplc Isorhamnetin (15 mg) 3,3',5,7-Tetrahydroxy-3'-Methoxyflavone Isorhamnetin USP/EP/BP Isorhamnetin, ≥95% (HPLC) 2'-0xydiethanol 2'-Oxybisethanol Isorhamnetin, 98%, from Hippophae fhamnoides L. Isorhamnetin 480-19-3 3,6,7-trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-1-benzopyran-4-one Isorhamnetin, >98%（HPLC) 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one 3-METHYLQUERCETIN ISOHAMNETIN QUERCETIN-3-METHYLETHER sorhamnetin 3,5,7-trihydroxy-2-(4-hydroxy-3-methoxy-phenyl)chromen-4-one 3,5,7-trihydroxy-2- (4-hydroxy-3-methoxyphenyl) -4H-benzopyran-4-one 480-19-3 418-19-3 Natural Dyes Biochemicals and Reagents BioChemical Penta-substituted Flavones Flavanols Aromatics Heterocycles Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals chemical reagent pharmaceutical intermediate