(S)-2-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamoyl)-4-methylpenty((R)-1-amino-3-phenylpropyl)phosphinic acid
- CAS No.
- 2007955-07-7
- Chemical Name:
- (S)-2-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamoyl)-4-methylpenty((R)-1-amino-3-phenylpropyl)phosphinic acid
- Synonyms
- DG013A;(S)-2-((S)-1-AMINO-3-(1H-INDOL-3-YL)-1-OXOPROPAN-2-YLCARBAMOYL)-4-METHYLPENTY((R)-1-AMINO-3-PHENYLPR;(S)-2-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamoyl)-4-methylpenty((R)-1-amino-3-phenylpropyl)phosphinic acid;((S)-2-(((S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)-4-methylpentyl)((R)-1-amino-3-phenylpropyl)phosphinic acid;Phosphinic acid, P-[(2S)-2-[[[(1S)-2-amino-1-(1H-indol-3-ylmethyl)-2-oxoethyl]amino]carbonyl]-4-methylpentyl]-P-[(1R)-1-amino-3-phenylpropyl]-
- CBNumber:
- CB04804565
- Molecular Formula:
- C27H37N4O4P
- Molecular Weight:
- 512.58
- MDL Number:
- MOL File:
- 2007955-07-7.mol
(S)-2-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamoyl)-4-methylpenty((R)-1-amino-3-phenylpropyl)phosphinic acid Chemical Properties,Uses,Production
Description
DG013A is a a phosphinic pseudotripeptide and ERAP2 inhibitor with nanomolar potency for ERAP2. A crystal structure of a phosphinic pseudotripeptide (DG013A) bound into the active site of ERAP2 revealed five distinct protein elements that were hypothesized to drive inhibitor potency.
Uses
DG013A?is a phosphinic acid tripeptide mimetic inhibitor. DG013A displays significantly weak affinity for both ERAP1 (IC50=33?nM)?and ERAP2 (IC50=11?nM). DG013A can be used for the research of autoimmune disease and cancer[1].
References
[1] Birgit Wilding,?et al. Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1. Bioorg Med Chem Lett.?2021 Jun 15;42:128050. DOI:10.1016/j.bmcl.2021.128050
(S)-2-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamoyl)-4-methylpenty((R)-1-amino-3-phenylpropyl)phosphinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
(S)-2-((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylcarbamoyl)-4-methylpenty((R)-1-amino-3-phenylpropyl)phosphinic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Suzhou Xinkai Bio-Medical Technology Co., Ltd. | 0512-67213637 13952409868 | peter19zhang@163.com | China | 442 | 55 |
| Shanghai Changyan Chem & Tech Co., Ltd. | 021-20242659 18930833303 | Sales@changyanchem.cn | China | 5010 | 55 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3018 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62072 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19949 | 58 |