Anti-MDC1 Antibody
- CAS No.
- Chemical Name:
- Anti-MDC1 Antibody
- Synonyms
- Anti-MDC1 Antibody
- CBNumber:
- CB04816335
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Anti-MDC1 Antibody price More Price(1)
Anti-MDC1 Antibody Chemical Properties,Uses,Production
Uses
Anti-MDC1 Antibody is a highly specific rabbit polyclonal antibody, that targets MDC1 (Mediator of DNA damage checkpoint protein 1) & has been tested in western blotting, ICC & IP.
General Description
Mediator of DNA damage checkpoint protein 1 (MDC1) is a subunit of the cohesin complex and is an essential protein required for sister chromatid cohesion in mitosis and meiosis. Temperature-sensitive mutations of this protein have been associated with defects in sister chromatid cohesion, chromosome condensation, and chromosome segregation. Its expression is cell cycle regulated and peaks in S phase. Expression of MDC1 is required for the S- and G2/M-checkpoint-mediated cell cycle arrest in response to DNA damage. MDC1 has been shown to interact with H2A.X near sites of DNA double-strand breaks and recruit ATM kinase to the damaged region of DNA. Consistent with this role, MDC1 also appears to modulate the function of other proteins involved in the DNA damage checkpoint such as BRCA1 and Chk2.
Anti-MDC1 Antibody Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-MDC1 Antibody Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Supplier | Advantage |
|---|---|
| Sigma-Aldrich | 80 |