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InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem

InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem Structure
InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem structure
CAS No.
Chemical Name:
InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem
Synonyms
InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem
CBNumber:
CB04817352
Molecular Formula:
Molecular Weight:
0
MDL Number:
MOL File:
Mol file
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InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 218705 InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem 1mg $209 2023-06-20 Buy
Product number Packaging Price Buy
218705 1mg $209 Buy

InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem Chemical Properties,Uses,Production

General Description

A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC50 = 200 nM from S. pombe; 0.3 μM for CK1δ) and ALK5 (IC50 = 500 nM). A weak inhibitor of p38α MAP kinase (IC50 = 12 μM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser322 and Ser325) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC50 = 2.5 μM for CK1).

Biochem/physiol Actions

Target IC50: 0.2 μM, 0.3 μM against CK1, CK1d, respectively

InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem Preparation Products And Raw materials

Raw materials

Preparation Products

InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem Suppliers

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InSolution Casein Kinase I Inhibitor, D4476 - Calbiochem