Wnt Antagonist I, IWR-1-endo - Calbiochem
- CAS No.
- Chemical Name:
- Wnt Antagonist I, IWR-1-endo - Calbiochem
- Synonyms
- Wnt Antagonist I, IWR-1-endo - Calbiochem
- CBNumber:
- CB04818122
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
Wnt Antagonist I, IWR-1-endo - Calbiochem price More Price(1)
Wnt Antagonist I, IWR-1-endo - Calbiochem Chemical Properties,Uses,Production
General Description
A cell-permeable p-imidobenzamidoquinoline, endo-diastereomer that is shown to inhibit the activity of TNKS1/PARP5a and TNKS2/PARP5b in in vitro auto-PARsylation assays (IC50 = 131 and 56 nM, respectively) and effectively suppress Wnt-stimulated transcription activity in L-Wnt-STF-based reporter assays (IC50 = 180 nM), while exhibiting little activity against PARP1 or PARP2 (IC50 >18.75 μM). Although both IWR-1-endo and XAV939 act as reversible Wnt pathway inhibitors and exhibit similar pharmacological effects both in vitro and in vivo, IWR-1-endo exerts its effect via interaction with Axin, while XAV939 binds TNKS directly.
Wnt Antagonist I, IWR-1-endo - Calbiochem Preparation Products And Raw materials
Raw materials
Preparation Products
Wnt Antagonist I, IWR-1-endo - Calbiochem Suppliers
Global( 1)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
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Sigma-Aldrich | 80 |
Wnt Antagonist I, IWR-1-endo - Calbiochem