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BAY707)

BAY707) Structure
BAY707) structure
CAS No.
2109805-96-9
Chemical Name:
BAY707)
Synonyms
BAY707);BAY-707 (BAY 707;BAY-707 free base;1H-Pyrrolo[2,3-b]pyridine-2-carboxamide, N-ethyl-4-[(3S)-3-methyl-4-morpholinyl]-
CBNumber:
CB04844527
Molecular Formula:
C15H20N4O2
Molecular Weight:
288.34
MDL Number:
MFCD31814430
MOL File:
2109805-96-9.mol
Last updated:2023-06-30 15:45:59
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BAY707) Properties

Density 1.225±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:28.83(Max Conc. mg/mL);100.0(Max Conc. mM)
Ethanol:2.88(Max Conc. mg/mL);10.0(Max Conc. mM)
pka 14.36±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

BAY707) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 6562 BAY707 ≥98%(HPLC) 2109805-96-9 5 $115 2021-12-16 Buy
Tocris 6562 BAY707 ≥98%(HPLC) 2109805-96-9 25 $485 2021-12-16 Buy
Product number Packaging Price Buy
6562 5 $115 Buy
6562 25 $485 Buy

BAY707) Chemical Properties,Uses,Production

Biological Activity

BAY-707 is a substrate-competitive, highly selective inhibitor of MTH1(NUDT1) with IC50 of 2.3 nM. It has a favorable pharmacokinetic profile compared to other MTH1 compounds and is well tolerated in mice, but the experiments clearly lack in vitro or in vivo anticancer efficacy.

in vivo

Bay-077 (orally adminstation; 50-250 mg/kg; 2 weeks) exhibits superior biochemical potency, cellular target engagement, and a pharmacokinetic profile to other MTH1 tool compounds, But Bay-077 exerts no anticancer efficacy either in mono- or in combination therapies in CT26 and NCI-H460 mice model.

target

IC50: 2.3 nM (MTH1/NUDT1)

storage

Store at -20°C

BAY707) Preparation Products And Raw materials

Raw materials

Preparation Products

BAY707) Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 52927 58
ChemCell Biomedicine Co.,Ltd. 020-13556033878 2965585218 13556033878 chemcell@hotmail.com China 369 52
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 15317229551 15151849396@163.com China 997 58
Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369 3477467573@qq.com China 8618 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 psaitong@jm-bio.com China 29778 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24131 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 4030 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
ChemCell Biomedicine Co.,Ltd. 52
Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd 58
Changzhou Furuisi Biotechnology Co., Ltd 58
Beijing Jin Ming Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
BAY-707 (BAY 707 BAY707) 1H-Pyrrolo[2,3-b]pyridine-2-carboxamide, N-ethyl-4-[(3S)-3-methyl-4-morpholinyl]- BAY-707 free base 2109805-96-9