ChemicalBook
Chinese Japanese Germany Korea

SWAINSONINE

SWAINSONINE
SWAINSONINE structure
CAS No.
72741-87-8
Chemical Name:
SWAINSONINE
Synonyms
8AR)-1;SwainMoia;Tridolgosir;SWAINSONINE;D-Swainsonine;SWAINSONINE 98+%;(-)-D-Swainsonine;Swainsonine min. 99%;swainsonine synthetic;swainsonine from locoweed
CBNumber:
CB0484750
Molecular Formula:
C8H15NO3
Formula Weight:
173.21
MOL File:
72741-87-8.mol

SWAINSONINE Properties

Melting point:
148-149°C
Boiling point:
353.3±21.0 °C(Predicted)
Density 
1.38±0.1 g/cm3 (20 ºC 760 Torr)
storage temp. 
-20°C
solubility 
H2O: soluble1mg/mL
pka
14.01±0.60(Predicted)
form 
lyophilized powder
color 
white to faint yellow
BRN 
4175740
CAS DataBase Reference
72741-87-8
FDA UNII
RSY4RK37KQ
SAFETY
  • Risk and Safety Statements
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
RTECS  NM2408666
HS Code  29339900

SWAINSONINE price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 574775-M Swainsonine Reversible active-site inhibitor of lysosomal α-mannosidase. 72741-87-8 500ug-m $78.1 2020-08-18 Buy
Sigma-Aldrich 574775-M Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem Reversible active-site inhibitor of lysosomal α-mannosidase. 72741-87-8 500 μg $78.1 2021-03-22 Buy
Sigma-Aldrich S9263 Swainsonine synthetic 72741-87-8 0.1 mg $146 2021-03-22 Buy
Sigma-Aldrich S8195 Swainsonine from Metarrhizium anisopliae, ≥98% (TLC) 72741-87-8 1mg $412 2021-03-22 Buy
Sigma-Aldrich S9263 Swainsonine synthetic 72741-87-8 0.5 mg $502 2021-03-22 Buy

SWAINSONINE Chemical Properties,Uses,Production

Chemical Properties

White Crystalline Solid

Occurrence

Swainsonia canescens yields this simple alkaloid.

Uses

Swainsonine is an indolizidine alkaloid naturally found in certain plants including locoweed that inhibits N-linked glycoside hydrolases, preventing the processing of asparagine-linked glycoproteins. It reversibly inhibits lysosomal α-mannosidase and Golgi α-mannosidase II (IC50 = 0.2 μM). Swainsonine is used to study the role of N-linked glycosylation in cellular processes and has been shown to have antiproliferative and antimetastatic effects of cancer cells in culture and in mice. The inhibition of α-mannosidase activity in lysosomes produces an accumulation of partially-processed oligosaccharides and glycoproteins, giving rise to lysosomal storage disease. Swainsonine toxicity in herbivores results in a condition known as locoism, characterized by hyperactivity, aggression, stiff and clumsy gait, low head carriage, salivation, seizures, and apparent blindness, culminating in increased miscoordination, weakness and death.

Uses

Swainsonine is a plant alkaloid derived from Swainsona canescens (a leguminous plant). It is a reversible, active-site directed inhibitor of a-mannosidase at concentrations of 5-10mM. At acid pH, swainsonine resembles an intermediate in the hydrolysis of mannosidases. Swainsonine completely inhibits mammalian Golgi a-mannosidase II (a-3/6-mannosidase in the glycoprotein processing pathway) and mammalian lysosomal a-mannosidase (acid mannosidase). At higher concentrations, swainsonine also inhibits mammalian cytosolic a-mannosidase. It has been shown to inhibit growth of transformed fibroblasts in soft agar and to enhance the antiproliferative effects of INF on murine lymphoreticular tumor cells in vitro. It also blocks the expression of b1-6 branched complex-type oligosaccharides and shunts the pathway towards hybrid-type oligosaccharides. Swainsonine does not appear to inhibit secretion or expression of glycoproteins at the cell surface. Swainsonine is stable for at least 24 h at 37oC in culture media at physiological pH. Working concentration range is 17-1700 ng/ml (0.1-10mM). Swainsonine (at 1 mg/ml) is not cytotoxic and does not inhibit the growth of a variety of mammalian cell lines. Concentrations required to inhibit Golgi a-mannosidase II in vivo may be somewhat higher, as swainsonine tends to concentrate in the acid environment of cell lysosomes, where it exists as a charged cation and does not permeate through membranes readily. Swainsonine blocks the processing of high-mannose oligosaccharides to complex oligosaccharides. Glycoproteins synthesized in the presence of swainsonine tend to carry mostly high-mannose and hybrid oligosaccharide chains. With short treatments (<24 h) with the inhibitor, cells may retain some complex glycoproteins due to asynchronous cell growth and glycoprotein synthesis.

Definition

ChEBI: An indolizidine alkaloid isolated from the plant Swainsona canescens with three hydroxy substituents at positions 1, 2 and 8.

Biological Activity

Inhibitor of α -mannosidase II which inhibits glycoprotein processing. Displays anticancer and immune modulatory properties.

SWAINSONINE Preparation Products And Raw materials

Raw materials

Preparation Products


SWAINSONINE Suppliers

Global( 131)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Nanjing Shizhou Biotechnology Co., Ltd
(+86)18013869214
(+86)25-85563444 sean.lv@synzest.com CHINA 2360 58
Nanjing Shizhou Biotechnology Co., Ltd
(+86)18013869214
(+86)25-85563444 sean.lv@synzest.com CHINA 2360 58
Wuhan ChemNorm Biotech Co.,Ltd.
18971486879 +86-27-8439 4403
+86-27-8439 4403 sales@chemnorm.com CHINA 2936 58
Target Molecule Corp
18019718960 781-999-5354
marketing@targetmol.com United States 19232 58

View Lastest Price from SWAINSONINE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-01-09 SWAINSONINE
72741-87-8
US $1.00 / ASSAYS 1ASSAYS 85.0-99.8% 20tons Career Henan Chemical Co

72741-87-8(SWAINSONINE)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved