ChemicalBook
Chinese Japanese Germany Korea

Pramipexole

Pramipexole
Pramipexole structure
CAS No.
104632-26-0
Chemical Name:
Pramipexole
Synonyms
SND-919;pramipexol;Pramipexole;(S)-Pramipexole;PraMipexole Base;Pramipexole (USAN);Pramipexole free base;Pramipexole alkaline;PRAMIPEXOLE 2HCL MONOHYDRATE;Pramipexol diclorohidrato monohidrato
CBNumber:
CB0486178
Molecular Formula:
C10H17N3S
Formula Weight:
211.33
MOL File:
104632-26-0.mol

Pramipexole Properties

Melting point:
288-290°C
storage temp. 
-20°C Freezer
CAS DataBase Reference
104632-26-0(CAS DataBase Reference)

SAFETY

Pramipexole price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy

Pramipexole Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Uses

partial/full D2S, D2L, D3, D4 receptor agonist

Uses

(S)-Pramipexole enantiomer. s disease (PD) and restless legs syndrome (RLS).[1] It is also sometimes used off-label as a treatment for cluster headache and to counteract the problems with sexual dysfunction experienced by some u sers of the selective serotonin reuptake inhibitor (SSRI) antidepressants.

Uses

(S)-Pramipexole enantiomer. A dopamine-D2-receptor agonist. Antiparkinsonian

Definition

ChEBI: A member of the class of benzothiazoles that is 4,5,6,7-tetrahydro-1,3-benzothiazole in which the hydrogens at the 2 and 6-pro-S-positions are substituted by amino and propylamino groups, respectively.

Enzyme inhibitor

This non-ergoline receptor agonist (FWfree-base = 211.33 g/mol; CAS 104632-26-0; FWdiHCl-monohydrate = 302.26 g/mol; CAS = 191217-81-9; Solubility = 42 mg/mL DMSO), also known as (S)-N6-propyl-4,5,6,7- tetrahydrobenzo[d]thiazole-2,6-diamine, Mirapexin, Sifrol, and SND-919, exerts partial/full antagonist action on dopamine D2S (Ki = 3.9 nM), D2L (Ki = 2.2 nM), D3 (Ki = 0.5 nM), and D4 (Ki = 5.1 nM) receptors. D2S and D2L are G protein-coupled receptors that respectively participate in presynaptic and postsynaptic dopaminergic transmission; D3 subtype receptors inhibit adenylyl cyclase through inhibitory G-proteins; as does the D4 subtype. Although L-DOPA is the gold-standard for treating Parkinson Disease, its effectiveness fades rapidly and its continued use can result in serious motor fluctuations. Pramipexole selectively acts at dopamine receptors in the D2 subfamily an possesses full activity that is comparable to dopamine. Its preferential affinity for the D3 receptor subtype may well account for its efficacy in the treatment of both the motor and psychiatric symptoms of Parkinson disease. Unlike the long-term use of the ergotderived dopamine agonists, pramipexole does not carry the risk to induce valvular heart disease or pulmonary and retroperitoneal fibrosis. Key Pharmacokinetic Parameters: See Appendix II in Goodman & Gilman’s THE PHARMACOLOGICAL BASIS OF THERAPEUTICS, 12th Edition (Brunton, Chabner & Knollmann, eds.) McGraw-Hill Medical, New York.

Pramipexole Preparation Products And Raw materials

Raw materials

Preparation Products


Pramipexole Suppliers

Global( 195)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21830 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20676 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32452 55
Hebei Chisure Biotechnology Co., Ltd.
+8613292890173
0311 66567340 luna@speedgainpharma.com CHINA 1019 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 25796 58
Jinan Jianfeng Chemical Co., Ltd
15562555968
info@pharmachemm.com CHINA 294 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23957 58
Accela ChemBio Inc.
(+1)-858-699-3322
(+1)-858-876-1948 info@accelachem.com United States 12233 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 1082 58

View Lastest Price from Pramipexole manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-07-05 Pramipexole
104632-26-0
US $10.00 / KG 1KG 99% 10 mt Hebei Guanlang Biotechnology Co., Ltd.
2018-08-20 Pramipexole
104632-26-0
US $1.00 / KG 1G 98% 100KG career henan chemical co
2018-07-30 Pramipexole
104632-26-0
US $10.00 / KG 10G 99% 500kg/month Hebei Chisure Biotechnology Co., Ltd.

104632-26-0(Pramipexole)Related Search:


  • (S)-4,5,6,7-TETRAHYDRO-N6-PROPYL-2,6-BENZOTHIAZOLEDIAMINE
  • (s)-2-amino-6-propylamino-4,5,6,7-tetrahydrobenzthiazole
  • n'-propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diamine
  • pramipexol
  • (S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazoltetrahydrobenzothiazol
  • PRAMIPEXOLE: PRAMIPEXOLE DIHYDROCHLORIDE
  • Pramipexol diclorohidrato monohidrato
  • PRAMIPEXOLE 2HCL MONOHYDRATE
  • Pramipexole
  • [(6S)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]-propyl-amine
  • N~6~-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine dihydrochloride
  • Pramipexole (USAN)
  • SND-919
  • (6S)-4,5,6,7-Tetrahydro-2-amino-6α-(propylamino)benzothiazole
  • (6S)-N'-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6α-diamine
  • (S)-4,5,6,7-Tetrahydro-N'-propylbenzothiazole-2,6-diamine
  • (S)-6-(Propylamino)-4,5,6,7-tetrahydrobenzothiazole-2-amine
  • (S)-Pramipexole
  • Pramipexole free base
  • (S)-N6-Propyl-4,5,6,7-tetrahydrobenzothiazole-2,6-diaMine
  • (6R)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diaMine
  • PraMipexole Base
  • PraMipexole(S)-2-AMino-6-propylaMino-4,5,6,7-tetrahydrobenzthiazole
  • (S)-N6-Propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diaMine
  • (6S)-4,5,6,7-Tetrahydro-N6-propyl-2,6-benzo[d]thiazolediamine
  • (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole
  • Pramipexole alkaline
  • (S)-4,5,6,7-tetrhydro-N6-propyl-2,6-benzothiazolediamine
  • -
  • (6S)-N6-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
  • (6S)-N'-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine
  • All Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Chiral Reagents
  • Sulfur & Selenium Compounds
  • API
  • Mirapexin, Sifrol
  • 104632-26-0
  • C10H17N3S
  • C10H21Cl2N3OS
  • C10H18ClN3S
Copyright 2017 © ChemicalBook. All rights reserved