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Troglitazone

Troglitazone
Troglitazone
CAS No.
97322-87-7
Chemical Name:
Troglitazone
Synonyms
ci991;CS-045;Noscal;rezulin;Depotox;gr92132x;AKOS 91980;ROMGLIZONE;RESULIN(TM);TROGLITAZONE
CBNumber:
CB0486895
Molecular Formula:
C24H27NO5S
Formula Weight:
441.54
MOL File:
97322-87-7.mol

Troglitazone Properties

Melting point:
184-186°C
storage temp. 
Store at -20°C
solubility 
DMSO: 20 mg/mL
form 
solid
color 
white to yellow
InChIKey
GXPHKUHSUJUWKP-UHFFFAOYSA-N
CAS DataBase Reference
97322-87-7(CAS DataBase Reference)

SAFETY

Safety Statements  22-24/25
WGK Germany  2
RTECS  XJ5813130

Troglitazone price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 648469-M Troglitazone 97322-87-7 5mg-m $162 2018-11-20 Buy
Cayman Chemical 71750 Troglitazone ≥98% 97322-87-7 5mg $47 2018-11-13 Buy
Cayman Chemical 71750 Troglitazone ≥98% 97322-87-7 10mg $89 2018-11-13 Buy
Cayman Chemical 71750 Troglitazone ≥98% 97322-87-7 50mg $376 2018-11-13 Buy
Cayman Chemical 71750 Troglitazone ≥98% 97322-87-7 100mg $658 2018-11-13 Buy

Troglitazone Chemical Properties,Uses,Production

Chemical Properties

Crystalline Solid

Uses

Troglitazone is an an oral hypoglycemic agent which improves insulin sensitivity and decreases hepatic glucose production. Antidiabetic.

Uses

antidiabetic;peroxisome proliferator-activated receptors activator

Uses

Troglitazone is a TZD which was approved for the treatment of insulin resistance and hyperglycemia in Type II diabetes, under the trade name Resulin?, but was withdrawn from the market due to hepatotoxicity. Troglitazone is a potent and selective PPARγ agonist. The EC50 values for transactivation of human and mouse PPARγ in a cell-based assay are 0.55 and 0.78 μM, respectively. In the same assay system, no activation of PPARα and PPARδ was observed at concentrations up to 10 μM. Troglitazone binds to the PPARγ ligand-binding domain (LBD) but fails to induce interaction of the PPARγ LBD with the transcriptional coactivators SRC-1, TIF2, AIB1, p300, or TRAP220. Troglitazone also induces cell cycle arrest and apoptosis in several cancer cell lines with an EC50 of 10 μM.

brand name

Prelay (Sankyo); Rezulin (Pfizer).

Biological Activity

Selective PPAR γ receptor agonist (EC 50 values are 780 and 555 nM at murine and human PPAR γ receptors respectively). Displays no activity at PPAR α or PPAR δ receptors. Antidiabetic agent; exerts potent glucose-lowering effects in insulin-resistant diabetic mice. Displays anti-invasive effect on human breast cancer cells; reduces migration, adhesion and spreading on fibronectin-coated plates. Also inhibits lamellipodia formation and actin polymerization.

Troglitazone Preparation Products And Raw materials

Raw materials

Preparation Products


Troglitazone Suppliers

Global( 102)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22058 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20795 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32764 55
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0086-13720134139
candy@biochempartner.com CHINA 956 58
Jinan Mingya Medical Technology Co., Ltd. +86-531-85828981 18866807006
+86-531-85806006 864598798@qq.com China 589 58
JiNan Weiran Biological Technology Co., Ltd. 13306417006; 18866807006; 0531-85868981
0531-85806006 864598798@qq.com China 502 50
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QQ158848739 zqsax2006@126.com China 96 50
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3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:18930552037
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97322-87-7(Troglitazone)Related Search:


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  • 5-[[4-[(3,4-DIHYDRO-6-HYDROXY-2,5,7,8-TETRAMETHYL-2H-1-BENZOPYRAN-2-YL)METHOXY]PHENYL]METHYL]-2,4-THIOAZOLIDINEDIONE
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  • TroglitazoneMesylate
  • 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]-phenyl]methyl]-2,4-thiazolidinedione, Romglizone, CS-045, CI-991,Noscal,
  • Troglitazone for research
  • CS-045, (±)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione
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  • 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-y1)methoxy]phenyl]methyl]-2.4-thiazolidinedione
  • 2,4-Thiazolidinedione, 5-((4-((3,4-dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl) methoxy)phenyl)methyl)
  • 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione
  • Depotox
  • Noscal
  • Troglitazone(Rezulin)
  • Troglitazone, >=98%
  • Troglitazone(CS-045)
  • RESULIN(TM)
  • ROMGLIZONE
  • PPAR and RXR Regulators
  • Gene Regulation and Expression
  • Active Pharmaceutical Ingredients
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Intracellular receptor
  • Aromatics
  • Heterocycles
  • Sulfur & Selenium Compounds
  • 97332-87-7
  • 7322-87-7
  • C24H27NO5S
  • C25H29NO4S
  • TROGLITAZONE
  • Troglitazone Solution, 100ppm
  • 97322-87-7
  • BioChemical
  • Cell Biology
  • Cell Signaling and Neuroscience
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