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ChemicalBook >> CAS DataBase List >>7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Structure
7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE structure
CAS No.
15421-84-8
Chemical Name:
7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE
Synonyms
ar12008;Trapymin;TRAPIDIL;Avantrin;rocornal;Trapymine;Trapidil CRS;Trapidil (AR12008);Trapidil >=98% (HPLC);5-methyl-7-diaethylamino-s-triazolo(1.5-a)pyrimidin
CBNumber:
CB0487317
Molecular Formula:
C10H15N5
Molecular Weight:
205.26
MDL Number:
MFCD00193104
MOL File:
15421-84-8.mol
Last updated:2024-04-03 17:07:09
Request For Quotation

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Properties

Melting point 98-99.4° (Pfeifer); 102-104° from heptane (Tenor)
Density 1.20±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: ≥15mg/mL
pka pKs = 2.79(at 25℃)
form powder
color white to tan
CAS DataBase Reference 15421-84-8
FDA UNII EYG5Y6355E
ATC code C01DX11

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26
WGK Germany  3
Toxicity LD50 in mice, rats (mg/kg): 115, 76 i.v.; 380, 235 orally; 155, 100 i.p.; 132, 100 s.c. (Fuller)
NFPA 704
0
2 0

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML0071 Trapidil ≥98% (HPLC) 15421-84-8 50mg $474 2022-05-15 Buy
Sigma-Aldrich T1820000 Trapidil European Pharmacopoeia (EP) Reference Standard 15421-84-8 t1820000 $223 2024-03-01 Buy
Biosynth Carbosynth FD153326 N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine 15421-84-8 100mg $60 2021-12-16 Buy
Biosynth Carbosynth FD153326 N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine 15421-84-8 1g $250 2021-12-16 Buy
ChemScene CS-4529 Trapidil >98.0% 15421-84-8 50mg $288 2021-12-16 Buy
Product number Packaging Price Buy
SML0071 50mg $474 Buy
T1820000 t1820000 $223 Buy
FD153326 100mg $60 Buy
FD153326 1g $250 Buy
CS-4529 50mg $288 Buy

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder

Originator

Rocornal,Mochida,Japan,1978

Uses

Vasodilator;PDGF antagonist

Definition

ChEBI: Trapidil is a member of triazolopyrimidines.

Manufacturing Process

8.4 g of 5-methyl-7-chloro-s-triazolo-(1,5-a)-pyrimidine were suspended in 30 cc of water and 7.3 g of diethylamine added. After 2 hours heating with stirring, the mixture was concentrated under vacuum. The residue was recrystallized from n-heptane. This process yielded 8.1 g of the 5-methyl-7- diethylamino-s-triazolo-(1,5-a)-pyrimidine having a melting point of 103°C to 104°C. The hydrochloride produced in the usual manner had a melting point of 212°C.

Therapeutic Function

Coronary vasodilator

Safety Profile

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. An experimental teratogen. Other experimental reproductive effects. A coronary vasodilator. When heated to decomposition it emits toxic fumes of NOx. See also MINES.

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Phosphorus oxychloride Diethylamine 3-Amino-1,2,4-Triazole Acetic acid

Preparation Products

7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE Suppliers

Global( 119)Suppliers
Supplier Tel Email Country ProdList Advantage
airuikechemical co., ltd. 		+undefined86-15315557071 sales02@airuikechemical.com China 994 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32480 60
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671 sales@tnjchem.com China 34572 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 9358 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Supplier Advantage
airuikechemical co., ltd. 		58
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
Hubei Jusheng Technology Co.,Ltd. 		58
BOC Sciences 		58
CONIER CHEM AND PHARMA LIMITED 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Shaanxi Dideu Medichem Co. Ltd 		58
AFINE CHEMICALS LIMITED 		58

View Lastest Price from 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Trapidil pictures 2024-04-03 Trapidil
15421-84-8
 US $0.00-0.00 / g 1g 99.99% 20 tons airuikechemical co., ltd.
Trapidil pictures 2020-05-12 Trapidil
15421-84-8
 US $0.00-0.00 / KG 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd
  • Trapidil pictures
  • Trapidil
    15421-84-8
  • US $0.00-0.00 / g
  • 99.99%
  • airuikechemical co., ltd.
  • Trapidil pictures
  • Trapidil
    15421-84-8
  • US $0.00-0.00 / KG
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd

15421-84-8(7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE)Related Search:

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4-(5-CHLOROMETHYL-[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER BUTTPARK 126\40-87 BUTTPARK 54\40-31 5-METHYL-8-(2-PIPERIDINOETHYL)-7,8-DIHYDRO-6H-PYRROLO[3,2-E][1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE BUTTPARK 126\40-85
BUTTPARK 54\40-28 5-METHYL-7-PIPERAZIN-1-YL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE BUTTPARK 126\40-84 BUTTPARK 57\40-36 BUTTPARK 54\40-30
BUTTPARK 54\40-29 BUTTPARK 113\40-54 8-(4-METHOXYBENZYL)-5-METHYL-7,8-DIHYDRO-6H-PYRROLO[3,2-E][1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE

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TRAPIDIL 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE 7-Diethylamino-5-methyl[1,2,4]triazolo[1,5-a]pyrimidine N,N-Diethyl-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-amine Trapymin N,N-Diethyl-5-methyl-[1,2,4]triazolo[5,1-b]pyrimidin-7-amine 7-(Diethylamino)-5-methyl-S-triazolo[1,5-a]pyrimidine ,98% Avantrin Trapymine 5-a)pyrimidin-7-amine,n,n-diethyl-5-methyl-s-triazolo( 5-methyl-7-diaethylamino-s-triazolo(1.5-a)pyrimidin 5-methyl-7-diethylamino-s-triazolo-(1,5-a)-pyrimidine ar12008 n,n-diethyl-5-methyl-(1,2,4)triazolo(1,5-a)pyrimidine-7-amine rocornal Trapidil CRS Trapidil >=98% (HPLC) 7-(DIETHYLAMINO)-5-METHYL-S-TRIAZOLO[1,5-A]PYRIMIDINE USP/EP/BP Trapidil (AR12008) [1,2,4]Triazolo[1,5-a]pyrimidin-7-amine,N,N-diethyl-5-methyl- N,N-Diethyl-4-methyl-1,5,7,9-Tetrazabicyclo[4.3.0]Nona-2,4,6,8-Tetraen-2-Amine 15421-84-8