3-(4-Methylpiperazin-1-yl)aniline
- CAS No.
- 148546-99-0
- Chemical Name:
- 3-(4-Methylpiperazin-1-yl)aniline
- Synonyms
- AKOS BB-8951;3-(4-Methylpiperazine) aniline;3-(4-Methypiperazin-1-yl)anilin;3-(4-METHYLPIPERAZIN-1-YL)ANILINE;3-(4-Methyl-1-piperazinyl)aniline;1-(3-Aminophenyl)-4-methylpiperazine;3-(4-Methyl-1-piperazinyl)aniline >3-(4-Methylpiperazin-1-yl)aniline 97%;3-(4-methylpiperazin-1-yl)benzenamine;3-(4-Methylpiperazin-1-yl)aniline ,97%
- CBNumber:
- CB0487397
- Molecular Formula:
- C11H17N3
- Molecular Weight:
- 191.27
- MDL Number:
- MFCD08435857
- MOL File:
- 148546-99-0.mol
| Product description | Number | Pack Size | Price |
| 3-(4-methylpiperazin-1-yl)aniline AldrichCPR | CDS004833 | 100mg | $68.1 |
| 3-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)(T) | A2714 | 1g | $37 |
| 3-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)(T) | A2714 | 5g | $147 |
| 3-(4-Methylpiperazin-1-yl)aniline | M218935 | 10mg | $45 |
| 3-(4-Methylpiperazin-1-yl)aniline 97% | 3H32-1-M8 | 5G | $61 |
| More product size | |||
| Melting point | 98-99 |
|---|---|
| Boiling point | 353.1±37.0 °C(Predicted) |
| Density | 1.092±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Methanol[soluble in] |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 7.88±0.42(Predicted) |
| color | White to Yellow to Orange |
| InChI | InChI=1S/C11H17N3/c1-13-5-7-14(8-6-13)11-4-2-3-10(12)9-11/h2-4,9H,5-8,12H2,1H3 |
| InChIKey | RJGHJWKQCJAJEP-UHFFFAOYSA-N |
| SMILES | C1(N)=CC=CC(N2CCN(C)CC2)=C1 |
| CAS DataBase Reference | 148546-99-0 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P280-P305+P351+P338-P310 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 20/21/22-34 | |||||||||
| Safety Statements | 22-26-36/37/39-45 | |||||||||
| RIDADR | 2923 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
3-(4-Methylpiperazin-1-yl)aniline price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CDS004833 | 3-(4-methylpiperazin-1-yl)aniline AldrichCPR | 148546-99-0 | 100mg | $68.1 | 2023-06-20 | Buy |
| TCI Chemical | A2714 | 3-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)(T) | 148546-99-0 | 1g | $37 | 2025-07-31 | Buy |
| TCI Chemical | A2714 | 3-(4-Methyl-1-piperazinyl)aniline >98.0%(GC)(T) | 148546-99-0 | 5g | $147 | 2025-07-31 | Buy |
| TRC | M218935 | 3-(4-Methylpiperazin-1-yl)aniline | 148546-99-0 | 10mg | $45 | 2021-12-16 | Buy |
| SynQuest Laboratories | 3H32-1-M8 | 3-(4-Methylpiperazin-1-yl)aniline 97% | 148546-99-0 | 5G | $61 | 2021-12-16 | Buy |
3-(4-Methylpiperazin-1-yl)aniline Chemical Properties,Uses,Production
Chemical Properties
Yellow solid
Synthesis
148546-97-8
148546-99-0
Step - (ii): Synthesis of 3-(4-methylpiperazin-1-yl)aniline: A methanolic solution of 1-methyl-4-(3-nitrophenyl)piperazine (15 g, 78.5 mmol) was mixed with a methanolic solution of 10% Pd/C (3 g) under stirring. The reaction was carried out under inert atmosphere with slow stirring and under hydrogen atmosphere for 4 hours at room temperature. After completion of the reaction, the reaction mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated to afford the target product 3-(4-methylpiperazin-1-yl)aniline (11 g, 87%) as a light yellow solid. Mass spectrum (electrospray ionization) m/z: 192 (M + 1).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5221 - 5224
[2] Patent: WO2007/18941, 2007, A2. Location in patent: Page/Page column 96-97
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5099 - 5119
[4] RSC Advances, 2018, vol. 8, # 22, p. 11871 - 11885
[5] Patent: WO2014/125410, 2014, A1. Location in patent: Page/Page column 39; 40
3-(4-Methylpiperazin-1-yl)aniline Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10035 | 58 |
| Unipharm pharmaceutical industry Co., Ltd | 536-8266195 +8613953676784 | lee@unipharm-sd.com | China | 1202 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
