ACA
- CAS No.
- 110683-10-8
- Chemical Name:
- ACA
- Synonyms
- ACA;4-amylcinnamoylanthranilicacid;N-(P-AMYLCINNAMOYL)ANTHRANILIC ACID;N-(p-Amylcinnamoyl) anthranilic Acid (ACA);2-(3-(4-Pentylphenyl)acrylamido)benzoic acid;2-[[(E)-3-(4-PENTYLPHENYL)PROP-2-ENOYL]AMINO]BENZOIC ACID;Benzoic acid, 2-[[1-oxo-3-(4-pentylphenyl)-2-propen-1-yl]amino]-;N(pamylcinnamoyl) Anthranilic Acid,Phospholipase,N (p amylcinnamoyl) Anthranilic Acid,inhibit,TRP Channel,Transient receptor potential channels,Inhibitor
- CBNumber:
- CB0489432
- Molecular Formula:
- C21H23NO3
- Molecular Weight:
- 337.41
- MDL Number:
- MFCD00211365
- MOL File:
- 110683-10-8.mol
- MSDS File:
- SDS
| Melting point | 172-174℃ |
|---|---|
| Boiling point | 563.1±50.0 °C(Predicted) |
| Density | 1.178±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly, Heated), Methanol (Slightly) |
| pka | 3.49±0.36(Predicted) |
| form | White solid. |
| color | White to Off-White |
| FDA UNII | LCJ9M6AJ5F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS09 |
|---|---|
| Signal word | Warning |
| Hazard statements | H410 |
| Precautionary statements | P403-P501c |
| HazardClass | 9 |
ACA price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Alfa Aesar | J67339 | N-(4-n-Pentylcinnamoyl)anthranilic acid | 110683-10-8 | 50mg | $151 | 2023-06-20 | Buy |
| Cayman Chemical | 14531 | N-(p-amylcinnamoyl) Anthranilic Acid ≥95% | 110683-10-8 | 25mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 14531 | N-(p-amylcinnamoyl) Anthranilic Acid ≥95% | 110683-10-8 | 50mg | $92 | 2024-03-01 | Buy |
| Cayman Chemical | 14531 | N-(p-amylcinnamoyl) Anthranilic Acid ≥95% | 110683-10-8 | 100mg | $168 | 2024-03-01 | Buy |
| Cayman Chemical | 14531 | N-(p-amylcinnamoyl) Anthranilic Acid ≥95% | 110683-10-8 | 250mg | $330 | 2024-03-01 | Buy |
ACA Chemical Properties,Uses,Production
Uses
N-(p-amylcinnamoyl) Anthranilic acid (ACA) is a channel blocker that acts on several transient receptor potential (TRP) channels, including TRPM2, TRPM8, and TRPC6 (IC50 = 1.7, 3.8, and 2.3 μM, respectively). It is a weak inhibitor of TRPV1. ACA is also an inhibitor of phospholipase A2, blocking the release of arachidonic acid when given at 50 μM.
Definition
ChEBI: N-(p-amylcinnamoyl)anthranilic acid is an amidobenzoic acid that is anthranilic acid in which one of the anilino hydrogens is replaced by a 4-pentylcinnamoyl group. It is a transient receptor potential (TRP) channel blocker and phospholipase A2 (PLA2) inhibitor. It has a role as an EC 3.1.1.4 (phospholipase A2) inhibitor and a TRP channel blocker. It is an amidobenzoic acid, a member of cinnamamides and a secondary carboxamide.
References
harteneck c, frenzel h, kraft r. n-(p-amylcinnamoyl)anthranilic acid (aca): a phospholipase a(2) inhibitor and trp channel blocker. cardiovasc drug rev. 2007 spring;25(1):61-75.kraft r, grimm c, frenzel h, et al. inhibition of trpm2 cation channels by n-(p-amylcinnamoyl)anthranilic acid. br j pharmacol. 2006 jun;148(3):264-73.gwanyanya a, macianskiene r, bito v, et al. inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by n-(p-amylcinnamoyl)anthranilic acid (aca). biochem biophys res commun. 2010 nov 19;402(3):531-6.
ACA Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |