TETRODOTOXIN
- CAS No.
- 4368-28-9
- Chemical Name:
- TETRODOTOXIN
- Synonyms
- TTX;bjt-1;tetrodoxin;TTX citrate;maculotoxin;spheroidine;FUGU POISON;tarichatoxin;TETRODOTOXIN;tetrodontoxin
- CBNumber:
- CB0489528
- Molecular Formula:
- C11H17N3O8
- Molecular Weight:
- 319.27
- MDL Number:
- MFCD00213719
- MOL File:
- 4368-28-9.mol
| Melting point | 280 °C (decomp) |
|---|---|
| alpha | D25 -8.64° (c = 8.55 in dil acetic acid) |
| Boiling point | 458.31°C (rough estimate) |
| Density | 1.3768 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: stable at pH 4-5 if stored frozensoluble |
| form | powder |
| pka | 8.76 (water); 9.4 (50% alc) |
| color | white |
| Merck | 13,9318 |
| Stability | Acid Sensitive, Hygroscopic |
| CAS DataBase Reference | 4368-28-9(CAS DataBase Reference) |
| FDA UNII | 3KUM2721U9 |
| EPA Substance Registry System | Tetrodotoxin (4368-28-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H330-H300-H310 | |||||||||
| Precautionary statements | P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 26/27/28 | |||||||||
| Safety Statements | 22-36/37/39-45-36/37-28 | |||||||||
| RIDADR | UN 3462 6.1/PG 1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | IO1450000 | |||||||||
| F | 10-18 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 30029090 | |||||||||
| Toxicity | LD50 i.p. in mice: 10 mg/kg (Kao, Fuhrman) | |||||||||
| NFPA 704 |
|
TETRODOTOXIN price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 14963 | Tetrodotoxin ≥98% | 4368-28-9 | 1mg | $231 | 2024-03-01 | Buy |
| Cayman Chemical | 14964 | Tetrodotoxin Citrate ≥98% | 4368-28-9 | 1mg | $179 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT29063 | Tetrodotoxin - citrate free | 4368-28-9 | 1mg | $600 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT29063 | Tetrodotoxin - citrate free | 4368-28-9 | 2mg | $800 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT29063 | Tetrodotoxin - citrate free | 4368-28-9 | 5mg | $1000 | 2021-12-16 | Buy |
TETRODOTOXIN Chemical Properties,Uses,Production
Description
Tetraodotoxin is a kind of extremely potent toxin which exists in the liver and sex organs of some fishes including pufferfish, porcupine fish, ocean sunfish, and toadfish as well as some kind of amphibian, octopus and shellfish species. It is also produced by some bacteria such as Pseudomonas and Vibrio. Tetraodotoxin is extremely toxic to human, interfering with the transmission of signals of nerves to muscles and further causing paralysis of the body muscle. It can be fatal in some cases. Its mechanism of action is inhibiting the firing of action potentials in nerves through binding to the voltage-gated sodium channels in nerve cell membrane and blocking the passages of sodium ions into the nerve cell. People should wear proper protective equipment upon operations and should be subject to proper treatment upon suffering from it. However, it has been under investigation on the treatment of chronic and breakthrough pain in advanced cancer patients.
References
https://www.cdc.gov/niosh/ershdb/emergencyresponsecard_29750019.html https://en.wikipedia.org/wiki/Tetrodotoxin
Description
Tetrodotoxin (TTX) is a selective sodium channel blocker nonprotein heat-stable toxin. The mechanism of toxicity is through the blockage of fast voltage-gated sodium channels. The consumption of toxic amounts of TTX results primarily in neurologic and gastrointestinal signs and symptoms. TTX is widely distributed in marine taxa such as pufferfish and porcupine fish (suborders of the Tetraodontiformes order), salamanders of the family Salamandridae, Central American frogs (genus Atelopus), shellfish, starfish, crabs, and some species of ribbonworm and octopus. However, in terrestrial taxa, it is limited to a single class of vertebrates (Amphibia). TTX is now known to be produced not by puffer but by bacteria, and reaches various species of animals via food chain.
Chemical Properties
white powder
Uses
Tetrodotoxin is a highly selective, reversible sodium channel blocker.
Uses
TTX is an extremely popular chemical tool in the physiological and pharmacological laboratories since discovery of its channel blocking action in the early 1960s. Some potential therapeutic uses include suppressing pain in cancer patients, preventing ischemic damage of the brain that follows stroke, relieving the symptoms of withdrawal in opiate addicts, and using it as anesthetic agent.
Definition
ChEBI: A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.
Biological Activity
Selective inhibitor of Na + channel conductance. Binding is reversible and of high affinity (K d = 1-10 nM). Blocks in a use-dependent manner.
Safety Profile
Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits toxic fumes of Nox.
storage
-20°C (desiccate)
Toxicity evaluation
TTX is a selective sodium channel blocker that can block nerve and muscle conductions; action potentials are blocked while resting membrane potentials and resting membrane resistance are not affected. TTX blocks axonal transmission by lowering the conductance of sodium at nodes of Ranvier. Vomiting occurs because the toxin can act directly at or near the chemoreceptor trigger zone. Respiratory depression is caused by either a specific action of tetrodotoxin on the brain’s respiratory center or because paralysis of respiratory nerves and muscles occurs.
TETRODOTOXIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7786 | 58 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| Kingfirst chemical (nanjing) co.,ltd | 86-25-84522992 | marketing@kingfirstchem.com | CHINA | 95 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
Related articles
- Tetrodotoxin-A Natural Deadly Neurotoxin
- Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual ....
- Oct 24，2019
View Lastest Price from TETRODOTOXIN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-23 | TETRODOTOXIN
4368-28-9
|
US $8.00-6.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2021-08-12 | TETRODOTOXIN
4368-28-9
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- TETRODOTOXIN
4368-28-9
- US $8.00-6.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- TETRODOTOXIN
4368-28-9
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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