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5-Aminolevulinic acid hydrochloride

5-Aminolevulinic acid hydrochloride
5-Aminolevulinic acid hydrochloride structure
CAS No.
5451-09-2
Chemical Name:
5-Aminolevulinic acid hydrochloride
Synonyms
evuL;5-Ala;ALA-PDT;Gliolan;ALA HCL;5-AminoL;Levulan (TN);DELTA-ALA, HCL;5-Aminolevulinic;Levulan Kerastick
CBNumber:
CB0496757
Molecular Formula:
C5H10ClNO3
Formula Weight:
167.59
MOL File:
5451-09-2.mol

5-Aminolevulinic acid hydrochloride Properties

Melting point:
~150 °C (dec.)
Flash point:
155-157°C
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
powder
color 
White to pale yellow
PH
pH (10g/l, 25℃) : 2.5~3.0
Water Solubility 
Soluble in dimethyl sulfoxide, methanol and water.
Decomposition 
155-157 ºC
Sensitive 
Hygroscopic
Merck 
14,446
BRN 
3690651
InChIKey
ZLHFONARZHCSET-UHFFFAOYSA-N
CAS DataBase Reference
5451-09-2(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
V35KBM8JGR
NCI Dictionary of Cancer Terms
aminolevulinic acid hydrochloride; Levulan Kerastick
NCI Drug Dictionary
aminolevulinic acid hydrochloride
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-66-20/21/22-36/38
Safety Statements  26-36/37-37/39-36
WGK Germany  3
RTECS  OI1640000
3-8-10
Hazard Note  Irritant
HS Code  29224999
NFPA 704
1
1 0

5-Aminolevulinic acid hydrochloride price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical A0325 5-Aminolevulinic Acid Hydrochloride >98.0%(T) 5451-09-2 1g $115 2021-03-22 Buy
TCI Chemical A0325 5-Aminolevulinic Acid Hydrochloride >98.0%(T) 5451-09-2 100mg $25 2021-03-22 Buy
Alfa Aesar A16942 5-Aminolevulinic acid hydrochloride, 99% 5451-09-2 2g $212 2020-06-24 Buy
Cayman Chemical 9001902 5-Aminolevulinic Acid (hydrochloride) ≥98% 5451-09-2 500mg $55 2021-03-22 Buy
Cayman Chemical 9001902 5-Aminolevulinic Acid (hydrochloride) ≥98% 5451-09-2 1g $94 2021-03-22 Buy

5-Aminolevulinic acid hydrochloride Chemical Properties,Uses,Production

Chemical Properties

white to pale yellow crystals or

Originator

Levulan Kerastick,DUSA Pharmaceuticals Inc.

Uses

Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer).

Definition

ChEBI: A hydrochloride that is the monohydrochloride of 5-aminolevulinic acid. It is metabolised to protoporphyrin IX, a photoactive compound which accumulates in the skin. Used in combination with blue light illumination for the treatment of minimally to moderat ly thick actinic keratosis of the face or scalp.

Manufacturing Process

1) Oxidation Step
2.27 g (10.0 mmol) of N-furfurylphthalimide was charged into a three-necked glass flask equipped with an oxygen feed tube, a thermometer, and a reflux condenser, and dissolved in 100 ml of anhydrous pyridine. After the addition of 7.0 mg of Rose Bengal, oxygen gas was fed at a rate of 20 ml/min at 10°- 20°C under irradiation by light. A 27 W white fluorescent lamp was used as a light source and the radiation was performed from the outside of the flask. After 7 hours, the irradiation was terminated and the pyridine was evaporated under reduced pressure to obtain 2.47 g of a light brown, semi-crystalline product.
2) Reduction Step (Hydrogenation)
2.00 g of the semi-crystalline solid obtained in (1) was dissolved in 40 ml of methanol and stirred at 50°C in a hydrogen atmosphere under atmospheric pressure in the presence of 200 mg of 5% palladium-on-carbon catalyst.
After five hours, the reaction was terminated and the mixture was allowed to cool to room temperature. The catalyst was removed by filtration and methanol was evaporated to obtain 2.11 g of white crystals.
The crystals were identified to be 5-phthalimidolevulinic acid by NMR analysis. The yield was 97%.
3) Hydrolysis Step
100 ml of 6 N hydrochloric acid was added to 2.11 g of the white crystals (2), and the mixture was heated under reflux for 5 hours.
After evaporating the hydrochloric acid under reduced pressure, a brown solid product was obtained and dissolved in ethanol. Acetone was added to the solution and the crystals produced were collected by filtration to obtain 0.689 g of 5-aminolevulinic acid hydrochloride. The yield based on Nfurfurylphthalimide was 51%.
NMR spectrum data conformed to 5-aminolevulinic acid hydrochloride

Therapeutic Function

Photosensitizer

Purification Methods

Dry ALA-HCl in a vacuum desiccator over P2O5 overnight, then crystallise it by dissolving it in cold EtOH and adding dry Et2O. Also crystallis

5-Aminolevulinic acid hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


5-Aminolevulinic acid hydrochloride Suppliers

Global( 447)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Pharmyao, All for life--- A Specific Trading Platform For Reference Standard Material
13560473592 020-81716320
020-81716319 sales@pharmyao.com CHINA 173 58
Hebei Yanxi Chemical Co., Ltd.
+8618633081222
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Shaanxi Youbang Biopharma Technology Co.,Ltd.
+86-13891932250
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Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21022 58
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0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
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Guangzhou PI PI Biotech Inc
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020-81716319 sales@pipitech.com;87478684@qq.com China 3245 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
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ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
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Shanxi Naipu Import and Export Co.,Ltd
+8613734021967
kaia@neputrading.com CHINA 1010 58

View Lastest Price from 5-Aminolevulinic acid hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 5-Aminolevulinic acid hydrochloride
5451-09-2
US $5.00 / KG 1KG 99% 30 Tons Wuhan wingroup Pharmaceutical Co., Ltd
2021-10-13 5-aminolevulinic acid hydrochloride
5451-09-2
US $2000.00 / KG 100g 98% 5t/Month Hebei Yirun Sega Biological Technology Co. Ltd
2021-09-30 5-Aminolevulinic acid hydrochloride
5451-09-2
US $0.00 / g 5g ≥98.0% 10kg/month WUHAN FORTUNA CHEMICAL CO., LTD

5-Aminolevulinic acid hydrochloride Spectrum


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