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MPEP HYDROCHLORIDE

MPEP HYDROCHLORIDE
MPEP HYDROCHLORIDE structure
CAS No.
219911-35-0
Chemical Name:
MPEP HYDROCHLORIDE
Synonyms
6-methyl-2-(phenylethynyl)pyridine;Pyridine, 6-methyl-2-(phenylethynyl)-;2-methyl-6-(phenylethynyl)pyridine(MPEP);MPVP replace pvp,White Crystal, New Stock!;6-Methyl-2-(phenylethynyl)pyridine hydrochloride;Pyridine,2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1);MPEP hydrochloride/219911-35-0/99% purity with low price in stock
CBNumber:
CB0498261
Molecular Formula:
C14H11N.ClH
Formula Weight:
229.709
MOL File:
219911-35-0.mol

MPEP HYDROCHLORIDE Properties

Melting point:
145-146℃
storage temp. 
room temp
solubility 
DMSO: 10 mg/mL
form 
solid
color 
off-white
InChIKey
PKDHDJBNEKXCBI-UHFFFAOYSA-N

SAFETY

WGK Germany  3

MPEP HYDROCHLORIDE price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich M5435 6-Methyl-2-(phenylethynyl)pyridine hydrochloride ≥98% (HPLC) 219911-35-0 5mg $98.8 2018-11-13 Buy
Sigma-Aldrich M5435 6-Methyl-2-(phenylethynyl)pyridine hydrochloride ≥98% (HPLC) 219911-35-0 25mg $353 2018-11-13 Buy
Cayman Chemical 14536 MPEP (hydrochloride) ≥98% 219911-35-0 5mg $39 2018-11-13 Buy
Cayman Chemical 14536 MPEP (hydrochloride) ≥98% 219911-35-0 10mg $66 2018-11-13 Buy
Cayman Chemical 14536 MPEP (hydrochloride) ≥98% 219911-35-0 25mg $156 2018-11-13 Buy

MPEP HYDROCHLORIDE Chemical Properties,Uses,Production

Definition

ChEBI: A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.

Uses

Glutamate, the major excitatory neurotransmitter in the brain, acts on both ionotropic and metabotropic glutamate receptors. Excessive metabotropic glutamate receptor (mGluR) transmission has been linked to epilepsy, ischemia, pain, anxiety, and depression. Eight subtypes (1-8) and multiple splice variants of the mGluR have been identified and grouped based on their pharmacological properties. Group I mGluRs (subtypes 1 and 5) activate the phosphatidyl inositol pathway, while Group II (2 and 3) and Group III (4, 6, 7 and 8) inhibit adenylyl cyclase. MPEP is a potent, highly selective non-competitive antagonist at the mGlu5a receptor subtype (IC50 = 36 nM) while having no agonist or antagonist activities at the mGlu1b receptor at concentrations up to 30 μM. MPEP is centrally active following systemic administration in vivo, inducing anxiolytic-like effects in rodent models of anxiety and depression when administered at 1-30 mg/kg. MPEP has also been reported as a positive allosteric modulator of mGluR4 at μM concentrations.

MPEP HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products


MPEP HYDROCHLORIDE Suppliers

Global( 40)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Changzhou Rongchuang Biotechnology Co., ltd.
0519-83991290 18115001290
0519-83991290 selena@rongchuangnet.com CHINA 39 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 16534 60
Hebei Jimi Trading Co., Ltd.
+86 017772612259 +86 319 5273535
admin@hebeijimi.com CHINA 306 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930501651
breeduan@crovellbio.com CHINA 901 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292893290
+8613292893290 Nancy@SpeedGainpharma.com CHINA 670 58
Haoyuan Chemexpress Co., Ltd. 86-21-58998985
(86) 21-58955996 apisales@chemexpress.com.cn China 7567 61
MedChemexpress LLC 609-228-6898
609-228-5909 sales@medchemexpress.com United States 4618 58
Shanghai TaoSu Biochemical Technology Co., Ltd. 021-33632979
021-33632979 zijuecai@targetmol.com China 2999 58
Shanghai JiYi Biotechnology Co. Ltd. 13621943973
- sales@jiyipharmatech.com China 1111 55
LETOPHARM LIMITED +86-21-5821 5861
+86-21-5106 2861 sales@letopharm.com China 2393 58

View Lastest Price from MPEP HYDROCHLORIDE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-03-26 MPEP hydrochloride/219911-35-0/99% purity with low price in stock
219911-35-0
US $1.00 / kg 1 公斤 99% 20tons Hebei Jimi Trading Co., Ltd.
2018-07-17 Resorcinol powder
108-46-3
US $10.00 / KG 10UG 99% 500kg/month Hebei Chisure Biotechnology Co., Ltd.

219911-35-0(MPEP HYDROCHLORIDE)Related Search:


  • 6-methyl-2-(phenylethynyl)pyridine
  • 2-methyl-6-(phenylethynyl)pyridine(MPEP)
  • Pyridine, 6-methyl-2-(phenylethynyl)-
  • MPEP hydrochloride/219911-35-0/99% purity with low price in stock
  • 219911-35-0
  • Inhibitors
  • 6-Methyl-2-(phenylethynyl)pyridine hydrochloride
  • Pyridine,2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1)
  • MPVP replace pvp,White Crystal, New Stock!
  • Medical research
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