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Paricalcitol

Paricalcitol structure

CAS No.: 131918-61-1

Chemical Name:: Paricalcitol

Synonyms: Zemplar;CS-1390;Zemplarr;PARICALCITOL;Paricalciferol;Paricalcitol, >=98%;Paricalcitol(Zemplar);19-Nor-1,25- dihydroxyvitaMin D2;1α,25-Dihydroxy-19-nor-vitaMin D2;19-nor-1alpha,25-dihydroxyvitamin D2

CBNumber:: CB0500520

Molecular Formula:: C27H44O3

Molecular Weight:: 416.65

MDL Number:

MOL File:: 131918-61-1.mol

MSDS File:: SDS

Last updated:2024-04-03 17:07:09

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Paricalcitol Properties

Boiling point	564.8±50.0 °C(Predicted)
Density	1.121±0.06 g/cm3(Predicted)
Flash point	14℃
storage temp.	Store at -20°C,unstable in solution, ready to use.
solubility	DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
pka	14.34±0.40(Predicted)
InChIKey	BPKAHTKRCLCHEA-UBFJEZKGSA-N
SMILES	C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C \|&1:1,10,13,16,20,22,26,r\|
CAS DataBase Reference	131918-61-1(CAS DataBase Reference)
FDA UNII	6702D36OG5
NCI Dictionary of Cancer Terms	paricalcitol
NCI Drug Dictionary	paricalcitol
ATC code	H05BX02

Pharmacokinetic data

Protein binding	>99%
Excreted unchanged in urine	0 (16% as metabolites)
Volume of distribution	17-25 Litres (6 Litres in haemodialysis patients)
Biological half-life	15 (oral 5-7) / Unchanged

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301+H311-H330-H372

Precautionary statements

P280-P301+P310+P330-P302+P352+P312-P304+P340+P310-P314

RIDADR

UN1170 - class 3 - PG 2 - Ethanol, solution

HS Code

2936299055

NFPA 704

	0
4		0

Paricalcitol price More Price(27)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	1499414	Paricalcitol	131918-61-1	3ml	$904	2024-03-01	Buy
Sigma-Aldrich	1499403	Paricalcitol	131918-61-1	10mg	$4260	2024-03-01	Buy
Cayman Chemical	17716	Paricalcitol ≥98%	131918-61-1	500μg	$98	2024-03-01	Buy
Cayman Chemical	17716	Paricalcitol ≥98%	131918-61-1	1mg	$186	2024-03-01	Buy
Cayman Chemical	17716	Paricalcitol ≥98%	131918-61-1	5mg	$778	2024-03-01	Buy

Product number	Packaging	Price	Buy
1499414	3ml	$904	Buy
1499403	10mg	$4260	Buy
17716	500μg	$98	Buy
17716	1mg	$186	Buy
17716	5mg	$778	Buy

Paricalcitol Chemical Properties,Uses,Production

Description

Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.

Description

Paricalcitol is a synthetic 1,25-dihydroxy vitamin D₂ analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.

Chemical Properties

White Solid

Originator

Abbott (US)

Uses

Antihyperparathyriod

Uses

1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.

Uses

Synthetic analog of vitamin D. Antihyperparathyroid.

Definition

ChEBI: Paricalcitol is a seco-cholestane and a hydroxy seco-steroid. It has a role as an antiparathyroid drug. It is functionally related to a vitamin D2.

brand name

Zemplar (Abbott).

Clinical Use

Vitamin D analogue:
Treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure

Metabolism

Extensively metabolised via hepatic and non-hepatic pathways to form two relatively inactive metabolites. After oral administration of 3 H-paricalcitol, only about 2% of the dose was eliminated unchanged in the faeces, and no parent drug found in the urine.
Approximately 70% of the radioactivity was eliminated in the faeces and 18% was recovered in the urine. Most of the systemic exposure was from the parent drug.

Paricalcitol Preparation Products And Raw materials

Raw materials

Preparation Products

Paricalcitol Suppliers

Global( 255)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
HangZhou RunYan Pharma Technology Co.,LTD.	+86-88660901 +86-18112526015	sales@runyanpharma.com	China	326	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15928	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21691	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9348	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

Supplier	Advantage
CONIER CHEM AND PHARMA LIMITED	58
HangZhou RunYan Pharma Technology Co.,LTD.	58
airuikechemical co., ltd.	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
Biochempartner	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from Paricalcitol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-23	Paricalcitol 131918-61-1	US $1.00 / g	1g	99%	10 tons	ANHUI WITOP BIOTECH CO., LTD
2024-04-03	Paricalcitol 131918-61-1	US $0.00-0.00 / Kg	1Kg	99.9%	20tons	airuikechemical co., ltd.
2023-03-13	Paricalcitol 131918-61-1	US $0.00 / kg	1kg	99.0%min. HPLC	1000kg	HangZhou RunYan Pharma Technology Co.,LTD.

Paricalcitol
131918-61-1
US $1.00 / g
99%
ANHUI WITOP BIOTECH CO., LTD

Paricalcitol
131918-61-1
US $0.00-0.00 / Kg
99.9%
airuikechemical co., ltd.

Paricalcitol
131918-61-1
US $0.00 / kg
99.0%min. HPLC
HangZhou RunYan Pharma Technology Co.,LTD.

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Paricalcitol Solution Paricalcitol 1(ALPHA) 25-DIHYDROXYVITAMIN D2*

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1α,25-Dihydroxy-19-nor-vitaMin D2 Paricalcitol/ 19-nor-1α,25-dihydroxyergocalciferol PARICALCITOL (10 MG)F0E3030.997MG/MG(AI) PARICALCITOL 19-nor-1alpha,25-dihydroxyvitamin D2 (1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)- Paricalcitol, >=98% 1,25-DihydroxyvitaMin D2 Paricalcitol Paricalcitol(Zemplar) Paricalcitol (10 mg) (COLD SHIPMENT REQUIRED) (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-Octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-triMethyl-2-hexen-1-yl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol (1α,3β,7E,22E)-19-Nor-9,10-secoergosta-5,7,22-triene-1,3,25-triol 19-Nor-1,25- dihydroxyvitaMin D2 (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((2R,5S,E)-6-hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)cyclohexane-1,3-diol ParicalcitolQ: What is Paricalcitol Q: What is the CAS Number of Paricalcitol Q: What is the storage condition of Paricalcitol Q: What are the applications of Paricalcitol Paricalcitol (COLD SHIPMENT REQUIRED) (1499403) CS-1390 Zemplar (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,E)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)cyclohexane-1,3-diol Paricalciferol Zemplarr 131918-61-1 131919-61-1 Vitamin D3 analogs Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals 131918-61-1