Paricalcitol
- CAS No.
- 131918-61-1
- Chemical Name:
- Paricalcitol
- Synonyms
- Zemplar;CS-1390;Zemplarr;PARICALCITOL;Paricalciferol;Paricalcitol, >=98%;Paricalcitol(Zemplar);19-Nor-1,25- dihydroxyvitaMin D2;1α,25-Dihydroxy-19-nor-vitaMin D2;19-nor-1alpha,25-dihydroxyvitamin D2
- CBNumber:
- CB0500520
- Molecular Formula:
- C27H44O3
- Molecular Weight:
- 416.65
- MDL Number:
- MOL File:
- 131918-61-1.mol
- MSDS File:
- SDS
Boiling point | 564.8±50.0 °C(Predicted) |
---|---|
Density | 1.121±0.06 g/cm3(Predicted) |
Flash point | 14℃ |
storage temp. | Store at -20°C,unstable in solution, ready to use. |
solubility | DMSO : 100 mg/mL (240.02 mM; Need ultrasonic)Ethanol : 12.5 mg/mL (30.00 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
pka | 14.34±0.40(Predicted) |
InChIKey | BPKAHTKRCLCHEA-UBFJEZKGSA-N |
SMILES | C[C@]12CCC/C(=C\C=C3C[C@@H](O)C[C@H](O)C3)/[C@]1([H])CC[C@]2([H])[C@H](C)/C=C/[C@H](C)C(O)(C)C |&1:1,10,13,16,20,22,26,r| |
CAS DataBase Reference | 131918-61-1(CAS DataBase Reference) |
FDA UNII | 6702D36OG5 |
NCI Dictionary of Cancer Terms | paricalcitol |
NCI Drug Dictionary | paricalcitol |
ATC code | H05BX02 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06,GHS08 |
|||||||||
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Signal word | Danger | |||||||||
Hazard statements | H301+H311-H330-H372 | |||||||||
Precautionary statements | P280-P301+P310+P330-P302+P352+P312-P304+P340+P310-P314 | |||||||||
RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution | |||||||||
HS Code | 2936299055 | |||||||||
NFPA 704 |
|
Paricalcitol price More Price(27)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 1499414 | Paricalcitol | 131918-61-1 | 3ml | $904 | 2024-03-01 | Buy |
Sigma-Aldrich | 1499403 | Paricalcitol | 131918-61-1 | 10mg | $4260 | 2024-03-01 | Buy |
Cayman Chemical | 17716 | Paricalcitol ≥98% | 131918-61-1 | 500μg | $98 | 2024-03-01 | Buy |
Cayman Chemical | 17716 | Paricalcitol ≥98% | 131918-61-1 | 1mg | $186 | 2024-03-01 | Buy |
Cayman Chemical | 17716 | Paricalcitol ≥98% | 131918-61-1 | 5mg | $778 | 2024-03-01 | Buy |
Paricalcitol Chemical Properties,Uses,Production
Description
Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo.
Description
Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
Chemical Properties
White Solid
Originator
Abbott (US)
Uses
Antihyperparathyriod
Uses
1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well.
Uses
Synthetic analog of vitamin D. Antihyperparathyroid.
Definition
ChEBI: Paricalcitol is a seco-cholestane and a hydroxy seco-steroid. It has a role as an antiparathyroid drug. It is functionally related to a vitamin D2.
brand name
Zemplar (Abbott).
Clinical Use
Vitamin D analogue:
Treatment and prevention of secondary
hyperparathyroidism associated with chronic renal
failure
Metabolism
Extensively metabolised via hepatic and non-hepatic
pathways to form two relatively inactive metabolites.
After oral administration of 3
H-paricalcitol, only about
2% of the dose was eliminated unchanged in the faeces,
and no parent drug found in the urine.
Approximately
70% of the radioactivity was eliminated in the faeces and
18% was recovered in the urine. Most of the systemic
exposure was from the parent drug.
Paricalcitol Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
HangZhou RunYan Pharma Technology Co.,LTD. | +86-88660901 +86-18112526015 | sales@runyanpharma.com | China | 326 | 58 |
airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 994 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15928 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21691 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3620 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
View Lastest Price from Paricalcitol manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-23 | Paricalcitol
131918-61-1
|
US $1.00 / g | 1g | 99% | 10 tons | ANHUI WITOP BIOTECH CO., LTD | ||
2024-04-03 | Paricalcitol
131918-61-1
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 20tons | airuikechemical co., ltd. | ||
2023-03-13 | Paricalcitol
131918-61-1
|
US $0.00 / kg | 1kg | 99.0%min. HPLC | 1000kg | HangZhou RunYan Pharma Technology Co.,LTD. |
- Paricalcitol
131918-61-1
- US $1.00 / g
- 99%
- ANHUI WITOP BIOTECH CO., LTD
- Paricalcitol
131918-61-1
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
- Paricalcitol
131918-61-1
- US $0.00 / kg
- 99.0%min. HPLC
- HangZhou RunYan Pharma Technology Co.,LTD.
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