Tianeptine
- CAS No.
- 72797-41-2
- Chemical Name:
- Tianeptine
- Synonyms
- Tianeptin;TPI-1062;TIANEPTINE;JNJ-39823277;Einecs 276-851-9;72797-41-2;7-[(3-Chloro-6,11-dihydro-6-methyl-5,5-dioxidodibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid;7-((3-chloro-6-methyl-5,5-dioxido-6,11-dihydrodibenzo[c,f][1,2]thiazepin-11-yl)amino)heptanoic acid;(1)-7-((3-Chloro-6,11-dihydro-6-methyldibenzo(C,F)(1,2)thiazepin-11-yl)amino)heptanoic acid S,S-dioxide;(±)-7-[(3-chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic acid S,S-dioxide
- CBNumber:
- CB0504881
- Molecular Formula:
- C21H25ClN2O4S
- Molecular Weight:
- 436.95
- MDL Number:
- MFCD00865376
- MOL File:
- 72797-41-2.mol
| Melting point | 129-131?C |
|---|---|
| Boiling point | 609.2±65.0 °C(Predicted) |
| Density | 1.38±0.1 g/cm3(Predicted) |
| vapor pressure | 0.001Pa at 25℃ |
| storage temp. | Refrigerator, Under Inert Atmosphere |
| pka | 4.75±0.10(Predicted) |
| form | solid |
| InChIKey | JICJBGPOMZQUBB-UHFFFAOYSA-N |
| SMILES | C(O)(=O)CCCCCCNC1C2=CC=C(Cl)C=C2S(=O)(=O)N(C)C2=CC=CC=C21 |
| LogP | 2.162 at 25℃ and pH6 |
| FDA UNII | 0T493YFU8O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H362-H361-H373 |
| Precautionary statements | P201-P260-P263-P264-P270-P308+P313-P260-P314-P501-P201-P202-P281-P308+P313-P405-P501 |
| WGK Germany | 3 |
Tianeptine price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T436800 | Tianeptine | 72797-41-2 | 5mg | $85 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28263 | Tianeptine | 72797-41-2 | 1g | $120 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28263 | Tianeptine | 72797-41-2 | 5mg | $124.9 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28263 | Tianeptine | 72797-41-2 | 2g | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FT28263 | Tianeptine | 72797-41-2 | 10mg | $227.2 | 2021-12-16 | Buy |
Tianeptine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. It is used mainly in the treatment of major depressive disorder and may also be used to treat anxiety, asthma, and irritable bowel syndrome. It has been found to act as an atypical agonist of the μ-opioid receptor with clinically negligible effects on the δ- and κ-opioid receptors. Tianeptine prevents chronic stress-induced morphological changes in the hippocampus and amygdala and blocks the effects of acute stress on synaptic plasticity in the hippocampus and PFC.
Definition
ChEBI: Tianeptine is a racemate comprising of equimolar amounts of (R)- and (S)-tianeptine. It is an atypical antidepressant used in Europe to treat patients who respond poorly to selective serotonin reuptake inhibitors (SSRIs). It has a role as a mu-opioid receptor agonist, a second generation antipsychotic and an anxiolytic drug. It contains a (R)-tianeptine and a (S)-tianeptine.
brand name
Stablon, Tatinol, and Coaxil among others
Mechanism of action
Current research suggests that tianeptine produces its antidepressant effects through the modulation of glutamate receptor activity (for example, AMPA receptors and NMDA receptors) and affect the release of brain-derived neurotrophic factor (BDNF), which impacts neural plasticity.
Tianeptine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Kangcang new material Technology Co., LTD | +8619133911216 | Jany1001@kangcang.com.cn | China | 331 | 58 |
| Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 524 | 58 |
| Hunan aslsen technology co.,ltd | +8615308460054 | aslsc@aslsen.com | China | 124 | 58 |
| Jinan Jianfeng Chemical Co., Ltd | 0531-88110457; +8615562555968 | info@pharmachemm.com | China | 246 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23556 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
| Hong Kong Excellence Biotechnology Co., Ltd. | +86-86-18838029171 +8618126314766 | ada@sh-teruiop.com | China | 892 | 58 |
View Lastest Price from Tianeptine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-16 | Tianeptine
72797-41-2
|
US $10.00 / kg | 1kg | 99% | 10000 tons | Hunan aslsen technology co.,ltd | |
 |
2024-04-16 | Tianeptine | US $5.00 / kg | 0.10000000149011612kg | 99.99% | 20tons | Hebei Kangcang new material Technology Co., LTD | |
 |
2024-04-16 | Tianeptine /acid
72797-41-2
|
US $2000.00-1500.00 / kg | 1kg | 99.99% | 100ton/ month | Hebei Kangcang new material Technology Co., LTD |
-
- Tianeptine
72797-41-2
- US $10.00 / kg
- 99%
- Hunan aslsen technology co.,ltd
-
- Tianeptine
- US $5.00 / kg
- 99.99%
- Hebei Kangcang new material Technology Co., LTD
-
- Tianeptine /acid
72797-41-2
- US $2000.00-1500.00 / kg
- 99.99%
- Hebei Kangcang new material Technology Co., LTD