WS-383
- CAS No.
- 2247544-02-9
- Chemical Name:
- WS-383
- Synonyms
- WS-383;WS-383 hydrochloride;Ubiquitin conjugating enzyme,DCN1-UBC12,WS-383,E1 activating enzyme,WS 383,E3 ligating enzyme,WS383,interaction,KYSE70,E2 conjugating enzyme,cell,Ubiquitin ligase,E1/E2/E3 Enzyme,MGC-803,Inhibitor,Ubiquitin activating enzyme,inhibit
- CBNumber:
- CB05821439
- Molecular Formula:
- C18H21Cl2N9S2
- Molecular Weight:
- 498.45
- MDL Number:
- MOL File:
- 2247544-02-9.mol
WS-383 price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Tocris | 7055 | WS383 ≥98%(HPLC) | 2247544-02-9 | 10 | $169 | 2021-12-16 | Buy |
AK Scientific | 9577EN | 2-[5-[[2-[(4-Chlorophenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]sulfanyl]tetrazol-1-yl]-N,N-dimethylethanamine;hydrochloride | 2247544-02-9 | 10mg | $232 | 2021-12-16 | Buy |
ChemScene | CS-0090382 | WS-383 99.74% | 2247544-02-9 | 5mg | $420 | 2021-12-16 | Buy |
Biosynth Carbosynth | BW170250 | WS 383 hydrochloride NEW | 2247544-02-9 | 50mg | $472.5 | 2021-12-16 | Buy |
AK Scientific | 9577EN | 2-[5-[[2-[(4-Chlorophenyl)methylsulfanyl]-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl]sulfanyl]tetrazol-1-yl]-N,N-dimethylethanamine;hydrochloride | 2247544-02-9 | 50mg | $687 | 2021-12-16 | Buy |
WS-383 Chemical Properties,Uses,Production
Biological Activity
WS-383 is a potent, selective and reversible inhibitor of DCN1-UBC12 interaction, with an IC50 of 11 nM. WS-383 inhibits Cul3/1 neddylation, induces accumulation of p21, p27 and NRF2[1]. WS-383 (10 μM) is against a panel of kinases such as BTK, CDKs, and EGFR [L858R] using staurosporine and BIBW 2992 as the positive controls. WS-383 showed weak inhibitory activity at 10.0 μM,it is selective to the DCN1-UBC12 interaction over the selected kinasesr[1].WS-383 (0.03-3 μM;24 hours) blocks Cul3 neddylation at 3 μM and also has certain inhibition of Cul1 neddylation at 10 μM but was not effective in inhibiting neddylation of other cullin members[1].WS-383 (0.03-3 μM;24 hours) increases Cul1, Skp1 (adaptor protein), F-box protein, and RBX1/RBX2 RING protein form SCF E3 complex. Cyclin dependent kinase inhibitor 1A (p21) and cyclin dependent kinase inhibitor 1B (p27) expression in a dose-dependent manner in MGC-803 and KYSE70 manner[1].
storage
Store at -20°C
References
[1]. Wang S, et al. Development of Highly Potent, Selective, and Cellular Active Triazolo[1,5- a]pyrimidine-Based Inhibitors Targeting the DCN1-UBC12 Protein-Protein Interaction. J Med Chem. 2019 Mar 14;62(5):2772-2797.
WS-383 Preparation Products And Raw materials
Raw materials
Preparation Products
WS-383 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2985 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4011 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24131 | 58 |
Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2949 | 58 |
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd | 021-59167510 18117107507 | vip@med-life.cn | China | 5019 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |