GUANETHIDINE MONOSULPHATE

CAS No.
Chemical Name:
GUANETHIDINE MONOSULPHATE
Synonyms
GUANETHIDINE MONOSULPHATE
CBNumber:
CB0586894
Molecular Formula:
C10H24N4O4S
Molecular Weight:
296.38696
MDL Number:
MOL File:
Mol file

Pharmacokinetic data

Protein binding <5%
Excreted unchanged in urine 25-60%
Volume of distribution Large
Biological half-life 120-240 / Increased

GUANETHIDINE MONOSULPHATE Chemical Properties,Uses,Production

Clinical Use

Treatment of hypertensive crisis

Drug interactions

Potentially hazardous interactions with other drugs
Anaesthetics: enhanced hypotensive effect.
Sympathomimetics: hypotensive effect antagonised by dexamfetamine, ephedrine, isometheptene, lisdexamfetamine, metaraminol, methylphenidate, noradrenaline, oxymetazoline, phenylephrine, phenylpropanolamine, pseudoephedrine and xylometazoline.

Metabolism

Guanethidine is partially metabolised in the liver, and is excreted in the urine as metabolites and unchanged guanethidine.

GUANETHIDINE MONOSULPHATE Preparation Products And Raw materials

Raw materials

Preparation Products

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GUANETHIDINE MONOSULPHATE