MAC-545496
- CAS No.
- 838810-96-1
- Chemical Name:
- MAC-545496
- Synonyms
- MAC-545496;MAC-545496, 10 mM in DMSO;N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide;N-[[(5-Chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide;Benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)-;Bacterial,S. aureus,Antivirulence,Inhibitor,MAC545496,mprF,nanomolar,GraR,MAC-545496,MRSA,survival,inhibit,biofilm,MAC 545496,virulence,β-lactam
- CBNumber:
- CB06124311
- Molecular Formula:
- C18H18ClN5O3S
- Molecular Weight:
- 419.89
- MDL Number:
- MOL File:
- 838810-96-1.mol
| Density | 1.458±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (25 mg/ml) |
| form | solid |
| pka | 7.09±0.70(Predicted) |
| color | Yellow/orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
MAC-545496 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0109477 | MAC-545496 99.72% | 838810-96-1 | 5mg | $100 | 2021-12-16 | Buy |
| ChemScene | CS-0109477 | MAC-545496 99.72% | 838810-96-1 | 50mg | $450 | 2021-12-16 | Buy |
| ChemScene | CS-0109477 | MAC-545496 99.72% | 838810-96-1 | 10mg | $160 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0163-M005 | MAC-545496 ≥98%(HPLC) | 838810-96-1 | 5mg | $210 | 2021-12-16 | Buy |
| Ambeed | A1263957 | N-((5-Chloropyridin-2-yl)carbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide 98% | 838810-96-1 | 50mg | $360 | 2021-12-16 | Buy |
MAC-545496 Chemical Properties,Uses,Production
Description
MAC-545496 (838810-96-1) is an inhibitor of glycopeptide-resistance-associated protein R (GraR, also known as ApsR).? GraR and its regulatory system are important for virulence of S. aureus.? MAC-545496 is able to reverse ?-lactam resistance in S. aureus in a G. Mellonella larvae model.? 0.06 μg/mL MAC-545496? lowered the minimum inhibitory concentration (MIC) for oxacillin against S. aureus below the CLSI clinical breakpoint. It lowered the ?-lactam MIC from 512 to 8 μg/mL against S. aureus USA300.
Uses
MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA)[1].
in vivo
In vivo, MAC-545496 is effective as a monotherapy for MRSA infected Galleria mellonella larvae. MAC-545496 activity is evidenced by increased survival of the drug-treated larvae as compared to infected untreated ones. This corresponded to concentration-dependent killing of S. aureus in the hemolymph of the larvae observed from the CFUs recovered from the hemolymph 200 min after infection. Treatment of S. aureus-infected larvae with MAC-545496 occurred 30min after infection that mimics acquiring bacterial infection before initiating antimicrobial therapy [1].
References
El-Halfawy et al. (2020), Discovery of an antivirulence compound that reverses ?-lactam resistance in MRSA; Nat. Chem. Biol., 16 143
MAC-545496 Preparation Products And Raw materials
Raw materials
Preparation Products
MAC-545496 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32281 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30230 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38665 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4621 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 998 | 55 |
View Lastest Price from MAC-545496 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | MAC-545496
838810-96-1
|
US $36.00-59.00 / mg | 97.41% | 10g | TargetMol Chemicals Inc. |
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- MAC-545496
838810-96-1
- US $36.00-59.00 / mg
- 97.41%
- TargetMol Chemicals Inc.