ChemicalBook >> CAS DataBase List >>2-Chloro-1,3,2-dioxaphospholane-2-oxide

2-Chloro-1,3,2-dioxaphospholane-2-oxide

CAS No.
6609-64-9
Chemical Name:
2-Chloro-1,3,2-dioxaphospholane-2-oxide
Synonyms
2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE;ETHYLENE CHLOROPHOSPHATE;ETHYLENE CYCL-CHLOROPHOSPHATE;Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane);Ethylene chl;2-chloro-1,3,2;CYCLIC CHLOROPHOSPHATE;Ethylene chlorophosphate, tech. 90%;Ethylene glycol chlorophosphate, 95%;2-chloro-1,3,2λ?-dioxaphospholan-2-one
CBNumber:
CB0664909
Molecular Formula:
C2H4ClO3P
Molecular Weight:
142.48
MDL Number:
MFCD00043138
MOL File:
6609-64-9.mol
Last updated:2023-09-07 14:58:50

2-Chloro-1,3,2-dioxaphospholane-2-oxide Properties

Melting point 12-14 °C
Boiling point 89-91 °C0.8 mm Hg(lit.)
Density 1.55 g/mL at 25 °C(lit.)
vapor pressure 1.06hPa at 25℃
refractive index n20/D 1.45(lit.)
Flash point >230 °F
storage temp. -20°C
solubility Chloroform (Soluble), Ethyl Acetate (Slightly)
form Solid or Film
color White to off-white
Water Solubility Miscible with water and chloroform.
Sensitive Moisture Sensitive
BRN 606582
Stability Extremely moisture sensitive
InChIKey SBMUNILHNJLMBF-UHFFFAOYSA-N
LogP -0.485 at 25℃ and pH7
CAS DataBase Reference 6609-64-9(CAS DataBase Reference)
FDA UNII 7EBS5ZK92N

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P280-P305+P351+P338-P310
Hazard Codes  C
Risk Statements  14-34
Safety Statements  26-36/37/39-45-8-25-27
RIDADR  UN 3265 8/PG 2
WGK Germany  3
10
HazardClass  8
PackingGroup  II
HS Code  29209090
NFPA 704
1
3 2
W

2-Chloro-1,3,2-dioxaphospholane-2-oxide price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 377953 2-Chloro-1,3,2-dioxaphospholane 2-oxide 6609-64-9 5g $154 2024-03-01 Buy
TCI Chemical C1250 2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T) 6609-64-9 5g $85 2024-03-01 Buy
TCI Chemical C1250 2-Chloro-2-oxo-1,3,2-dioxaphospholane >95.0%(GC)(T) 6609-64-9 25g $261 2024-03-01 Buy
Alfa Aesar A18320 Ethylene chlorophosphate 95% 6609-64-9 5g $77.7 2023-06-20 Buy
Alfa Aesar A18320 Ethylene chlorophosphate 95% 6609-64-9 25g $290 2023-06-20 Buy
Product number Packaging Price Buy
377953 5g $154 Buy
C1250 5g $85 Buy
C1250 25g $261 Buy
A18320 5g $77.7 Buy
A18320 25g $290 Buy

2-Chloro-1,3,2-dioxaphospholane-2-oxide Chemical Properties,Uses,Production

Chemical Properties

clear colourless liquid

Uses

2-Chloro-1,3,2-dioxaphospholane 2-oxide may be used in the synthesis of:

  • 2-methacryloyloxyethylphosphorylcholine
  • miltefosine (hexadecylphosphocholine, MT) analogs
  • phosphoric acid 2-trimethylamino-ethyl ester undec-10-enyl ester
  • uridine nucleolipid, (2′,3′-O-16-hentriacontanyliden-uridine-5′-phosphocholine, PUPC)
  • adenosine nucleoamphiphile, (2′,3′-O-16-hentriacontanyliden-adenosine-5′-phosphocholine, PAPC)
  • structurally related phospholipids which are either conformationally restricted or flexible
  • phosphatidylcholines

Uses

Ethylene chlorophosphate is used in the syntheses of 2-methacryloyoxyethylphophocholine, phosphatidylcholines, 2',3'-O-16-hentriacontanyliden-adenosine-5'-phosphocholine and hexadecylphosphocholine. It is also involved the synthesis of alpha-naphthylphosphorylcholine, which is used to detect phospholipase C activity. It is an important reactant for the synthesis of a zwitterionic silane, UV-polymerizable lipids utilizing Chabrier reaction and block copolymers of poly(aliphatic ester) clickable polyphosphoester.

Uses

2-Chloro-1,3,2-dioxaphospholane-2-oxide is used in the synthesis of α-naphthylphosphorylcholine as a method to detect phospholipase C activity.

General Description

2-Chloro-1,3,2-dioxaphospholane 2-oxide (COP) is a cyclic chlorophosphate reagent that can be prepared from 2-chloro-1,3,2-dioxaphospholane by reacting with molecular oxygen.

Purification Methods

It should be distilled under high vacuum as some polymerisation occurs at -1atmospheric pressure. It has IR bands at 3012, 2933, 1477, 1366, 1325, 1040, 924 and 858 cm . It is hydrolysed to HOCH2CH2OPO3H2 in 30minutes in H2O at 100o [IR: Cox & Westheimer J Am Chem Soc 80 5441 1958]. [Beilstein 1 IV 2419.]

107-21-1
6609-64-9
Synthesis of 2-Chloro-1,3,2-dioxaphospholane-2-oxide from Ethylene glycol
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View Lastest Price from 2-Chloro-1,3,2-dioxaphospholane-2-oxide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-1,3,2-dioxaphospholane-2-oxide pictures 2024-02-22 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
US $1000.00 / KG 10g 99% 20tons Hubei Langyou International Trading Co., Ltd
2-Chloro-1,3,2-dioxaphospholane-2-oxide pictures 2023-09-07 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
2-Chloro-1,3,2-dioxaphospholane-2-oxide pictures 2022-09-16 2-Chloro-1,3,2-dioxaphospholane-2-oxide
6609-64-9
US $0.00-0.00 / KG 1KG 98% 1ton Henan Aochuang Chemical Co.,Ltd.
2-Chloro-1,3-dioxa-2-phosphacyclopentane 2-oxide Ethylene chlorophosphate, tech. 90% 2-Chloro-2-oxo-1,3,2-dioxaphospholane, Ethylene cycl-chlorophosphate 2-Chloro-1,3,2-dioxaphospholane-2-oxide, Ethylene cycl-chlorophosphate 1,3,2-Dioxaphospholane, 2-chloro-, 2-oxide CYCLIC CHLOROPHOSPHATE Ethylene glycol chlorophosphate, 95% 2-Chloro-1,3,2-dioxaphospholane-2-oxide,95% Ethylene chl 2-CHLORO-1,3,2-DIOXAPHOSPHOLANE-2-OXIDE 2-Chloro-1,2,3-dioxaphospholane-2-oxide 2-Chloro-2-oxo-1,3,2-dioxaphospholane > 2-chloro-2-oxo-1,3, 2-dioxophosphorus heterocyclopentane 2-Chloro-1,3,2-dioxaphospholane-2-oxide/ Ethylene Chlorophosphate 2-Chloro-1,3,2-dioxaphospholane-2-oxide (Technical Grade) 2-chloro-1,3,2λ?-dioxaphospholan-2-one 2-chloro-1,3,2 Ethylene cycl-chlorophosphate (2-chloro-2-oxo-1,3,2-dioxaphospholane) ETHYLENE CHLOROPHOSPHATE ETHYLENE CYCL-CHLOROPHOSPHATE 2-CHLORO-2-OXO-1,3,2-DIOXAPHOSPHOLANE 2-chloro-2-oxo-1,3, 2-dioxophosphoheterocyclopentane 2-Chloro-2-Oxido-1,3,2- Dioxaphospholane 6609-64-9 C2H4ClO3P Organic Building Blocks Phosphorus Halides Phosphorus Compounds Building Blocks Phosphorylating Agents DNA / RNA Synthesis Phosphorylation Biochemistry Nucleosides, Nucleotides & Related Reagents Phosphorylating and Phosphorothioating Agents Phosphorylation Protecting Agents, Phosphorylating Agents & Condensing Agents Synthetic Organic Chemistry