ChemicalBook
Chinese Japanese Germany Korea

Phloroglucinol

Feature reaction of phloroglucinol Chemical properties Uses Production method Hazards & Safety Information
Phloroglucinol
Phloroglucinol structure
CAS No.
108-73-6
Chemical Name:
Phloroglucinol
Synonyms
orog;Nero;orogL;ucinoL;Dilexan;Dolopax;Triogyl;Flocinon;Sinterol;108-73-6
CBNumber:
CB0667672
Molecular Formula:
C6H6O3
Formula Weight:
126.11
MOL File:
108-73-6.mol

Phloroglucinol Properties

Melting point:
215-220 °C
Boiling point:
194.21°C (rough estimate)
Density 
0.801 g/mL at 20 °C
refractive index 
n20/D 1.365
Flash point:
14 °C
storage temp. 
Store below +30°C.
solubility 
Soluble in diethyl ether, ethanol and pyridine.
form 
Crystalline Powder
pka
pK1:8.45(0);pK2:8.88(-1) (25°C)
color 
White to light beige
Water Solubility 
11.17g/L(room temperature)
Sensitive 
Light Sensitive & Hygroscopic
Merck 
14,7328
BRN 
1341907
InChIKey
QCDYQQDYXPDABM-UHFFFAOYSA-N
CAS DataBase Reference
108-73-6(CAS DataBase Reference)
EWG's Food Scores
3-6
FDA UNII
DHD7FFG6YS
ATC code
A03AX12
NIST Chemistry Reference
1,3,5-Benzenetriol(108-73-6)
EPA Substance Registry System
1,3,5-Benzenetriol (108-73-6)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H317-H319-H335
Precautionary statements  P280-P305+P351+P338-P261-P264-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P280a-P304+P340-P405-P501a
Hazard Codes  F,Xi
Risk Statements  11-36/37/38-34-43
Safety Statements  7-16-24/25-45-36/37/39-26-36/37-37/39
RIDADR  UN 1170 3/PG 2
WGK Germany  2
RTECS  SY1050000
TSCA  Yes
HS Code  29072900
Toxicity LD50 in mice, rats (g/kg): 4.7, 4.0 i.g. (Cahen)
NFPA 704
0
2 1

Phloroglucinol price More Price(46)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 79330 Phloroglucinol ≥99.0% (HPLC) 108-73-6 25g $30.4 2021-12-16 Buy
Sigma-Aldrich 1.07069 Phloroglucinol (1,3,5-trihydroxybenzene) for analysis 108-73-6 25 g $51.71 2021-12-16 Buy
Sigma-Aldrich 8.18887 Phloroglucinol for synthesis 108-73-6 100 g $85.56 2021-12-16 Buy
Sigma-Aldrich 79330 Phloroglucinol ≥99.0% (HPLC) 108-73-6 100g $86.5 2021-12-16 Buy
TCI Chemical P0249 Phloroglucinol Anhydrous >99.0%(HPLC) 108-73-6 25g $32 2021-12-16 Buy

Phloroglucinol Chemical Properties,Uses,Production

Feature reaction of phloroglucinol

Reaction of formaldehyde with phloroglucinol under alkaline conditions generates orange compound. The colorimetric assay determination of this compound at the maximum absorption wavelength of 460 nm, can be used to detect low or trace formaldehyde in textile and garment.
Since phloroglucinol may occur enol and keto tautomers, it can react with ammonia according following reaction:
Under the influence of ammonia, 1,3,5-Benzenetriamine can be obtained by keto reaction of phloroglucinol
Under the influence of ammonia, 1,3,5-Benzenetriamine can be obtained by keto reaction of phloroglucinol, while this amine can also hydrolyze in aqueous acid to generate phloroglucinol. Besides phloroglucinol can also have enol reaction.
phloroglucinol can also have enol reaction
The information above is edited by Andy from Chemicalbook.

Chemical properties

This product is a white or light yellow crystal or crystalline powder with melting point of 218 ℃. Usually it carries two molecular crystallization water ([6099-90-7]) and converts into anhydrous at 110 ℃. It can be dissolved in 100 parts of water, 10 parts of ethanol, and 0.5 parts of pyridine and is soluble in ether. Besides It partially decomposes when sublimation, and changes its color when exposed to the light. In addition it tastes sweet.

Uses

It can be used in verifications of antimony, arsenic, cerium, chromate, chromium, gold, iron, mercury, nitrites, osmium, palladium, tin, vanadium, vanillin and lignin, and measurement of furfural, pentose, pentosan, methanol, chloral hydrate, turpentine, Lignified cell tissues, free acid in gastric juice (HCl) and decalcified bone specimens. Besides it can also be used as biological reagent dyes.

Production method

2,4,6-aminobenzoic acid can be obtained by 2,4,6-trinitrobenzoic acid`s reduction of zinc particles. After its dilute solution was heated at reflux for 20h, acidified with hydrochloric acid, cooled and crystallized, phloroglucinol can be obtained with a yield of 46-53%.

Hazards & Safety Information

Category: Toxic substances
Toxicity grade: Moderate toxicity
Acute toxicity: oral-rat LD50: 4000 mg/kg; Oral-Mouse LD50: 4550 mg/kg
Flammability hazard characteristics: Combustible fire burning can cause smoke irritation
Storage characteristics: Ventilated, low-temperature and dry warehouse; and separately with oxidants
Extinguishing agents: Carbon dioxide, foam, sand and water mist

Description

Phloroglucinol is a naturally occurring phenol that exhibits diverse biological activities. Phloroglucinol protects V79-4 Chinese hamster lung fibroblast cells from oxidative stress and inhibits lipid peroxidation by scavenging reactive oxygen species (ROS). It induces apoptosis in HT-29 human colon cancer cells and inhibits metastasis of BT549 and MDA-MB-231 human breast cancer cells. Phloroglucinol protects primary neurons from β-amyloid-induced dendritic spine loss in vitro and shortens the latency to find the platform in a Morris water maze test in an Alzheimer’s disease (AD) mouse model. Phloroglucinol has been used to stain histological plant sections and in the synthesis of numerous natural products. Phloroglucinol slows the frequency and decreases the amplitude of contraction in isolated rabbit and rat intestine at a concentration of 100 and 1 μM, respectively. Formulations containing phloroglucinol have been used as antispasmodics.

Chemical Properties

white to light yellow crystal

Uses

Antispasmodic.

Uses

Phloroglucinol (1,3,5-trihydroxybenzene) is the core structure of a large family of substituted phenolics with broad, albeit weak, biological activity. Phloroglucinol is a useful metabolite for HPLC/DAD and bioassay dereplication.

Uses

diagnostic aid growth hormone releasing factor

Uses

A potentially useful hygroscopic biochemical.

Definition

ChEBI: A benzenetriol with hydroxy groups at position 1, 3 and 5.

General Description

Phloroglucinol is a trihydroxybenzene with antithrombotic, profibrinolytic, antimicrobial, antimalarial, cancer chemopreventive, anti-HIV and anti-leishmanial activities. Phloroglucinol (PG) is a biosynthetic precursor of the 2,4-diacetylphloroglucinol (DAPG) an antibiotic against soil-borne diseases. Phloroglucinol is a useful intermediate because it is polyfunctional.

Safety Profile

Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in diazo-type printing and textile dyeing, in microscopy as a bone specimen decalcifier

Purification Methods

Crystallise the triol from water, and store it in the dark under nitrogen. [Beilstein 6 IV 7361.]

Phloroglucinol Preparation Products And Raw materials

Raw materials

Preparation Products


Phloroglucinol Suppliers

Global( 428)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
HANGZHOU CLAP TECHNOLOGY CO.,LTD
13588875226 86-571-88216897、88216896
86-571-88216895 sales@hzclap.com CHINA 6469 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 15426 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Shanghai Time Chemicals CO., Ltd.
+8618017249410 +86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com China 1807 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 9134 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Jinan Finer Chemical Co., Ltd
+8615508631887 +86-531-88989536
+86-531-88989539 sales@finerchem.com CHINA 1735 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5943 58

View Lastest Price from Phloroglucinol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Phloroglucinol
108-73-6
US $10.70 / Kg/Bag 10g 99% 10000kg Hebei Crovell Biotech Co Ltd
2021-11-30 Phloroglucinol
108-73-6
US $238.00 / Kg/Bag 1KG 99% 10T Baoji Guokang Bio-Technology Co., Ltd.
2021-10-19 Phloroglucinol/Phloroglucinol dihydrate
108-73-6
US $48.00-40.00 / KG 1KG 99% 200tons Guangzhou Sunton Biotechnology Co., Ltd.

Phloroglucinol Spectrum


108-73-6(Phloroglucinol)Related Search:


Copyright 2017 © ChemicalBook. All rights reserved