Ticlopidine hydrochloride
- CAS No.
- 53885-35-1
- Chemical Name:
- Ticlopidine hydrochloride
- Synonyms
- Soper;tiklid;53-32c;4-c-32;ticlid;Tiklyd;ticlodix;Iparazin;panaldine;ticlodone
- CBNumber:
- CB0674371
- Molecular Formula:
- C14H14ClNS.ClH
- Molecular Weight:
- 300.25
- MDL Number:
- MFCD00079606
- MOL File:
- 53885-35-1.mol
- MSDS File:
- SDS
| Melting point | 205°C |
|---|---|
| Density | 1.37 g/cm3 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Sparingly soluble in water and in anhydrous ethanol, very slightly soluble in ethyl acetate. |
| pka | 7.64(at 25℃) |
| color | White |
| Water Solubility | Soluble to 100 mM in water and to 100 mM in DMSO. |
| λmax | 295nm(H2O)(lit.) |
| Merck | 14,9421 |
| CAS DataBase Reference | 53885-35-1(CAS DataBase Reference) |
| FDA UNII | A1L4914FMF |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 36-37/39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | XJ9089100 | |||||||||
| HS Code | 2934990002 | |||||||||
| Toxicity | LD50 in mice (mg/kg/24 hrs): 55 i.v.; >300 orally (Castaigne) | |||||||||
| NFPA 704 |
|
Ticlopidine hydrochloride price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T6654 | Ticlopidine hydrochloride analytical standard, for drug analysis | 53885-35-1 | 1g | $39.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR3367 | Ticlopidine hydrochloride certified reference material, pharmaceutical secondary standard | 53885-35-1 | 300MG | $208 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1667144 | Ticlopidine hydrochloride United States Pharmacopeia (USP) Reference Standard | 53885-35-1 | 150mg | $261.6 | 2024-03-01 | Buy |
| TCI Chemical | T3110 | Ticlopidine Hydrochloride >98.0%(HPLC)(N) | 53885-35-1 | 5g | $61 | 2024-03-01 | Buy |
| TCI Chemical | T3110 | Ticlopidine Hydrochloride >98.0%(HPLC)(N) | 53885-35-1 | 25g | $159 | 2024-03-01 | Buy |
Ticlopidine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Originator
Ticlid,Millot,France,1978
Uses
mucolytic, antibacterial, surface active agent
Uses
An antithrombotic. a platelet aggregation inhibitor
Uses
Ticlopidine hydrochloride is a selective P2Y12 receptor antagonist. It inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo.
Manufacturing Process
A solution of thieno[3,2-c]pyridine (13.5 g; 0.1 mol) and 2-chlorobenzyl
chloride (17.7 g) in acetonitrile (150 ml) is boiled during 4 hours.
After evaporation of the solvent, the solid residue consists of 5-(2-
chlorobenzyl)-thieno[3,2-c]pyridinium chloride which melts at 166°C
(derivative n° 30). This compound is taken up into a solution comprising
ethanol (300 ml) and water (100 ml). Sodium borohydride (NaBH4)(20 g) is
added portionwise to the solution maintained at room temperature. The
reaction medium is maintained under constant stirring during 12 hours and is
then evaporated. The residue is taken up into water and made acidic with
concentrated hydrochloric acid to destroy the excess reducing agent. The
mixture is then made alkaline with ammonia and extracted with ether. The
ether solution is washed with water, dried and evaporated. The oily residue is
dissolved in isopropanol (50 ml) and hydrochloric acid in ethanol solution is
then added thereto.
After filtration and recrystallization from ethanol, there are obtained 5-(2-
chlorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine hydrochloride crystals
(yield: 60%) having a melting point (Koefler block) of 190°C.
Therapeutic Function
Platelet aggregation inhibitor
Biological Activity
Selective P2Y 12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity following oral administration in vivo .
Ticlopidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 7845 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
View Lastest Price from Ticlopidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-24 | Ticlopidine hydrochloride
53885-35-1
|
US $6.00-0.90 / KG | 1KG | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2023-09-06 | Ticlopidine hydrochloride
53885-35-1
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-04-12 | Ticlopidine hydrochloride;Ticlopidine hcl
53885-35-1
|
US $1.00 / kg | 1kg | 99.58%HPLC | 5000tons/year | Wuhan Dujiang Industrial Co., Ltd. |
-
- Ticlopidine hydrochloride
53885-35-1
- US $6.00-0.90 / KG
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Ticlopidine hydrochloride
53885-35-1
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Ticlopidine hydrochloride;Ticlopidine hcl
53885-35-1
- US $1.00 / kg
- 99.58%HPLC
- Wuhan Dujiang Industrial Co., Ltd.
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