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ZPCK
- CAS No.
- 26049-94-5
- Chemical Name:
- ZPCK
- Synonyms
- ZPCK;SL-01;Z-PHE-CMK;NSC 251810;Z-L-Phe-CMK;Z-PHE-CH2CL;ZPCK USP/EP/BP;Z-L-Phe-Chloromethane;Z-PHE-CHLOROMETHYLKETONE;z-l-phe chloromethyl ketone
- CBNumber:
- CB0674649
- Molecular Formula:
- C18H18ClNO3
- Molecular Weight:
- 331.79
- MDL Number:
- MFCD00037114
- MOL File:
- 26049-94-5.mol
- MSDS File:
- SDS
Last updated:2023-06-08 09:02:15
| Melting point | 107-108 °C(lit.) |
|---|---|
| Boiling point | 503.1±50.0 °C(Predicted) |
| Density | 1.1630 (rough estimate) |
| refractive index | 1.6470 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming). |
| form | solid |
| pka | 10.74±0.46(Predicted) |
| color | White |
| optical activity | [α]23/D +30°, c = 1 in chloroform |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| CAS DataBase Reference | 26049-94-5 |
| EPA Substance Registry System | Benzyl [(1S)-3-chloro-2-oxo-1-benzylpropyl]carbamate (26049-94-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-27-36/37/39-45 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29225000 | |||||||||
| NFPA 704 |
|
ZPCK price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 860794 | Z-L-Phe chloromethyl ketone 98% | 26049-94-5 | 1g | $104.8 | 2024-03-01 | Buy |
| Cayman Chemical | 15225 | SL 01 ≥98% | 26049-94-5 | 250mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 15225 | SL 01 ≥98% | 26049-94-5 | 1g | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 15225 | SL 01 ≥98% | 26049-94-5 | 500mg | $68 | 2024-03-01 | Buy |
| TRC | S560010 | SL01 | 26049-94-5 | 50mg | $45 | 2021-12-16 | Buy |
ZPCK Chemical Properties,Uses,Production
Description
SL-01 (26049-94-5) inhibits the p53-MDM2 interaction (20 μM). Has also been shown to inhibit bovine chymotrypsin A-γ.
Chemical Properties
white powder
Uses
Enzyme inhibitor.
Uses
ZPCK's a peptidase from baker's yeast,and it is with esterase activities of carboxypeptidase Y.
Uses
SL 01 is a prodrug of gemcitabine , the nucleoside analog used intravenously to treat various cancers that was designed for improved oral bioavailability. SL 01 can inhibit the growth of human non-small cell lung cancer NCI-H460 cells, colon cancer HCT-116 cells, and breast cancer MCF-7 cells (IC50s = 0.78, 0.92, and 0.64 μM, respectively), inducing apoptosis. In nude mice bearing NCI-H460, HCT-116, or MCF-7 cancer cell xenografts, SL 01 at 10-50 μM/kg has been shown to delay tumor growth.
References
1) Li et al. (2011), A cell-based high-throughput assay for the screening of small-molecule inhibitors of p53-MDM2 interaction; J. Biomol. Screening, 16 450
ZPCK Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 88)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29576 | 58 |
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| NewCan Biotech Limited | +86-0571-86912261 +8613735419629 | sales@newcanbio.com | China | 10027 | 58 |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | sales@nextpeptide.com | China | 19915 | 58 |
| LUYUNJIA CHEMISTRY XIAMEN LIMITED | +86-592-5360779 +86-13055435203 | China | 5996 | 58 | |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 | cherry@crovellbio.com | China | 18458 | 58 |
| DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9365 | 58 |
26049-94-5(ZPCK)Related Search:
SL-01
carbamicacid,[3-chloro-2-oxo-1-(phenylmethyl)propyl]-,phenylmethylester,(s
(S)-benzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate
N-CBZ-L-PHENYLALANINE CHLOROMETHYL*KETON E
z-l-phe chloromethyl ketone
(S)-Penzyl [1-benzyl-3-chloro-2-oxopropyl]carbamate.
ZPCK, N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketone
(3S)-1-Chloro-3-(benzyloxycarbonylamino)-4-phenyl-2-butanone
[(S)-1-Benzyl-3-chloro-2-oxopropyl]carbamic acid benzyl ester
[(S)-α-(Chloroacetyl)phenethyl]carbamic acid benzyl ester
Z-L-Phe-Chloromethane
N-Carbobenzyloxy-L-phenylalanyl chloromethylketone,98%
N-Carbobenzyloxy-L-phenylalanyl chloromethyl ketoneN-CBZ-L-Phenylalanylchloromethyl ketone
NSC 251810
(S)-(1-benzyl-3-chloro-2-oxopropyl)carbamic
Z-L-Phe chloromethyl ketone 98%
(S)-Benzyl (4-chloro-3-oxo-1-phenylbutan-2-yl)carbamate
Z-L-Phe-CMK
Z-L-PHENYLALANINE-CHLOROMETHYLKETONE
Z-PHE-CH2CL
Z-PHE-CHLOROMETHYLKETONE
Z-PHE-CMK
ZPCK
N-CBZ-L-PHENYLETHYL CHLOROMETHYL KETONE
N-CBZ-L-PHENYLALANYL-CHLOROMETHYLKETONE
N-CARBOBENZYLOXY-L-PHENYLALANYL CHLOROMETHYL KETONE
N-ALPHA-CARBOBENZOXY-L-PHENYLALANINE CHLOROMETHYLKETONE
benzyl N-[(2S)-4-chloro-3-oxo-1-phenylbutan-2-yl]carbamate
Carbamic acid, N-[(1S)-3-chloro-2-oxo-1-(phenylmethyl)propyl]-, phenylmethyl ester
ZPCK USP/EP/BP
CBZ-L-Phe-Chloromethyl ketone
26049-94-5
C6H5CH2CHNHCO2CH2C6H5COCH2Cl
Phenylalanine Derivatives
Peptide Synthesis
Specialty Synthesis
Unnatural Amino Acid Derivatives