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4-Cyanopyridine

CAS No.
100-48-1
Chemical Name:
4-Cyanopyridine
Synonyms
ISONICOTINONITRILE;4-PYRIDINECARBONITRILE;Pyridine-4-carbonitrile;4-cyanopyridin;4-CYANOPYRIDINE;Cyanopyridine,4-;4-Pyridinenitrile;AKOS BBS-00004486;Isonicotinonitril;TIMTEC-BB SBB008923
CBNumber:
CB0688145
Molecular Formula:
C6H4N2
Molecular Weight:
104.11
MDL Number:
MFCD00006417
MOL File:
100-48-1.mol
MSDS File:
SDS
Last updated:2024-01-11 10:11:44

4-Cyanopyridine Properties

Melting point 76-79 °C(lit.)
Boiling point 196 °C
Density 1.1145 (rough estimate)
vapor pressure 41.9Pa at 25℃
refractive index 1.5242 (estimate)
Flash point 88 °C
storage temp. Sealed in dry,Room Temperature
solubility 40g/l
form Crystals or Powder
pka pK1:1.90(+1) (25°C)
color White to off-white
Water Solubility 3.2 g/100ml (16.4 ºC)
BRN 107712
Exposure limits NIOSH: IDLH 25 mg/m3
Stability Stable. Incompatible with strong bases, strong oxidizing agents, strong acids.
InChIKey GPHQHTOMRSGBNZ-UHFFFAOYSA-N
LogP 0.46 at 25℃
CAS DataBase Reference 100-48-1(CAS DataBase Reference)
FDA UNII BY3226D010
NIST Chemistry Reference 4-Pyridinecarbonitrile(100-48-1)
EPA Substance Registry System 4-Pyridinecarbonitrile (100-48-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Precautionary statements  P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36/37-24/25
RIDADR  3276
WGK Germany  3
TSCA  Yes
PackingGroup  III
HS Code  29333999
NFPA 704
2
2 0

4-Cyanopyridine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich C95005 4-Pyridinecarbonitrile 98% 100-48-1 100g $24.7 2024-03-01 Buy
TCI Chemical C0457 4-Cyanopyridine >98.0%(GC)(T) 100-48-1 25g $16 2024-03-01 Buy
TCI Chemical C0457 4-Cyanopyridine >98.0%(GC)(T) 100-48-1 100g $32 2024-03-01 Buy
Alfa Aesar A10286 4-Cyanopyridine, 98% 100-48-1 10g $23.3 2024-03-01 Buy
Alfa Aesar A10286 4-Cyanopyridine, 98% 100-48-1 100g $24.4 2024-03-01 Buy
Product number Packaging Price Buy
C95005 100g $24.7 Buy
C0457 25g $16 Buy
C0457 100g $32 Buy
A10286 10g $23.3 Buy
A10286 100g $24.4 Buy

4-Cyanopyridine Chemical Properties,Uses,Production

Chemical Properties

The cyanopyridines are as follows: 2-cyano-: A white to tan liquid or solid. Almond odor. Boiling point=2213℃ ; freezing/melting point=27℃ ; flash point=89℃ . 3-cyano-: a colorless liquid or gray crystal- line solid.

Chemical Properties

beige solid

Uses

4-Cyanopyridine is used as an intermediate in organic synthesis and pharmaceutical substances like isonicotinylhydrazide, which is used in the treatment of tuberculosis. It is used as a precursor for the preparation of isonicotinic acid and 4-diemthylaminopyridine (DMAP). It is involved in the synthesis of 6-methyl-2-pyridin-4-yl-pyrimidin-4-ylamine by reacting with acetonitrile.

Synthesis

4-Cyanopyridine is synthesised by the reaction of 4-methylpyridine with ammonia and air in the presence of a catalyst. The specific synthesis steps are as follows:
4-Methylpyridine and ammonia vaporisation preheating to 180-330°C, then into the mixing tank and air mixing uniformly, into the fixed-bed reactor by the top of the fixed-bed reactor after the distribution of the catalyst-filled reactor, the control of the reaction temperature in the range of 330-450 ° C, the reaction head pressure is controlled in the range of 0.020-0.070 KPa, the reaction temperature is controlled by molten salts, the reaction gas after the end of the reaction After the reaction, the reaction gas was condensed to sub-zero fractionation to obtain the crude product of 4-cyanopyridine, and the crude product was distilled to obtain the finished product of 4-cyanopyridine. The conversion rate of 4-methylpyridine was above 99%, and the yield of 4-cyanopyridine was above 98%.
4-Cyanopyridine synthesis

Potential Exposure

Limits in Air NIOSH IDLH525 mg/m3 NIOSH REL: (nitriles) 2 ppm, Ceiling Concentration, not to be exceeded in any 15-minute work period.

Shipping

UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).

Incompatibilities

Oxidizing agents, such as perchlorates, peroxides, and permanganates. Nitriles may polymerize in the presence of metals and some metal compounds. They are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give car- boxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids .

872-85-5
100-48-1
Synthesis of 4-Cyanopyridine from 4-Pyridinecarboxaldehyde
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View Lastest Price from 4-Cyanopyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Cyanopyridine pictures 2023-08-18 4-Cyanopyridine
100-48-1
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
4-Cyanopyridine pictures 2023-06-15 4-Cyanopyridine
100-48-1
US $68.00 / Kg/Bag 1KG 98% 10T Baoji Guokang Bio-Technology Co., Ltd.
4-Cyanopyridine pictures 2022-10-17 4-Cyanopyridine
100-48-1
US $1.00 / kg 1kg 99% 50000tons Hebei Duling International Trade Co. LTD
  • 4-Cyanopyridine pictures
  • 4-Cyanopyridine
    100-48-1
  • US $68.00 / Kg/Bag
  • 98%
  • Baoji Guokang Bio-Technology Co., Ltd.
  • 4-Cyanopyridine pictures
  • 4-Cyanopyridine
    100-48-1
  • US $1.00 / kg
  • 99%
  • Hebei Duling International Trade Co. LTD
ISONICOTINIC ACID NITRILE AKOS BBS-00004486 4-CYANOPYRIDINE 4-Pyridinecarbonitrile 98% 4-cyanopyridine (4-CP) TIMTEC-BB SBB008923 SPECS AC-907/25014099 gamma-Cyanopyridine 4-Pyridinenitrile Cyanopyridine,4- 4-cyanopyridin Isonicotinic cid nitrile 4-Cyanopyridine ,99% 4-Pyridinecarbonitrile,4-Cyanopyridine, Isonicotinic acid nitrile, Isonicotinonitrile 4-Pyridinecarbonitri 4-Cyanopyridine, 98% 100GR 4-Cyanopyridine, 98% 500GR 4-Cyanopyridine, 98% 5GR 4-Cyanopyridine, Isonicotinic acid nitrile, Isonicotinonitrile 4-Cyanopyridine,98% 4-PYRIDINECARBONITRILE FOR SYNTHESIS Topiroxostat impurity B(Isoniazid Impurity 5) Topiroxostat Impurity 2 ( Isoniazid Impurity 5 ) 4-Cyanopyridine/4-Pyridinenitrile Fampridine Impurity 2 (4-Cyanopyridine) 4-Cyanopyridine > Fampridine Impurity 2 Ethionamide EP Impurity B Fampridine Impurity 9(4-Cyanopyridine) Isonicotinonitril 4-Cyanopyridine ISO 9001:2015 REACH Ethionamide Impurity 2 (Ethionamide EP Impurity B) ISONICOTINONITRILE 4-PYRIDINECARBONITRILE Pyridine-4-carbonitrile 2-Methyl-104-nitrobenzyl&chloride Isoniazid EP Impurity C Isoniazid EP Impurity C(Topiroxostat Impurity B) 100-48-1 83880-65-9 C5H3NCN C6H4N Pyridines Heterocyclic Building Blocks Building Blocks C6 Heterocycle-Pyridine series cyanide Pyridines derivates bc0001