ChemicalBook
Chinese Japanese Germany Korea

Olopatadine

Olopatadine
Olopatadine structure
CAS No.
113806-05-6
Chemical Name:
Olopatadine
Synonyms
KW 4679;OLOPATADINE;propylidene);Olopatatadine;Olopatadine(W.S);a-Hydroxy-Olopatadine;Olopatadine Impurity E;Olopatadine USP/EP/BP;-2-(11-(3-(Dimethylamino);-6,11-dihydrodibenzo[b,e]oxepin-2-yl)
CBNumber:
CB0689142
Molecular Formula:
C21H23NO3
Formula Weight:
337.41
MOL File:
113806-05-6.mol

Olopatadine Properties

Melting point:
188-189.5°
CAS DataBase Reference
113806-05-6(CAS DataBase Reference)
FDA UNII
D27V6190PM
ATC code
R01AC08,S01GX09

Olopatadine price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC O574995 Olopatadine 113806-05-6 50mg $195 2021-12-16 Buy
TRC O574995 Olopatadine 113806-05-6 250mg $780 2021-12-16 Buy
Matrix Scientific 124926 Olopatadine 95+% 113806-05-6 1g $5940 2021-12-16 Buy
Alichem 113806056 (Z)-2-(11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)aceticacid 113806-05-6 1g $920.82 2021-12-16 Buy
Crysdot CD11348016 (Z)-2-(11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)aceticacid 97% 113806-05-6 25mg $320 2021-12-16 Buy

Olopatadine Chemical Properties,Uses,Production

Description

Olopatadine belongs to a kind of antihistamine reagent. It is a relatively selective H1-receptor antagonist and can inhibit the histamine release process from the mast cell, subsequently leading to temporary relief on the negative symptoms associated with histamine. It is devoid of effects on alpha-adrenergic, dopamine and muscarinic type I and II receptors. Its 0.1% solution can be used for topical administration to the eyes. It is indicated for the treatment of itching associated with allergic conjunctivitis.

Originator

Patanol,Alcon,UK

Uses

Olopatadine is a dual acting histamine H1-receptor antagonist and mast cell stabilizer. Antiallergic; antihistaminic.

Uses

Anti-allergic.

Manufacturing Process

402.4 g of phthalide and 200 g of sodium chloride and equal molecular quantity of p-hydroxyphenyl acetic acid are mixed with one another and stirred at 150°C for 6 hours. After completion of the reaction, the mixture is cooled until the temperature is brought back to room temperature, 4 L of aqueous 10% acetic acid solution is added thereto and the mixture is allowed to stand at room temperature overnight. After stirring the mixture at room temperature for 3 hours, deposited crystals are separated by filtration, and 6 L of water is added thereto. After stirring the mixture at room temperature for 30 minutes, the deposited crystals are separated by filtration. After the addition of 3 L of toluene to the crystals, the mixture is stirred at room temperature for one hour. The crystals are separated by filtration and dried over heating under reduced pressure to yield of 2-(4-acetoxyphenoxy)benzoic acid.
266.0 g of trifluoroacetic anhydride is added to the equal molecular quantity of 2-(4-acetoxyphenoxy)benzoic acid suspended in 5.0 L of methylene chloride and thereto. After stirring the mixture at room temperature for one hour, 19.4 g of boron trifluoride-ethylether complex is added thereto and the mixture is stirred at room temperature for two hours. The reaction solution is poured into ice water. After an organic solvent layer is separated from the mixture, the organic layer is washed with diluted aqueous sodium hydroxide solution and water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to obtain 335.3 g of methyl 11-oxodibenz[b,e]oxepin-2- carboxylate as a white crystal melting point 130°-132°C Methyl 11-methylene-6,11-dihydrodibenz-[b,e]oxepin-2-acetate.
In 100 ml of tetrahydrofuran is suspended 25 g of methyltriphenylphosphonium bromide and 40 ml of 1.6 N n-butyl lithium hexane solution is dropwise added thereto under a nitrogen atmosphere and ice-cooling. After stirring the mixture under ice-cooling for 30 minutes, a solution obtained by dissolving equal molar quantity of 11-oxo-6,11- dihydrodibenz[b,e]oxepin-2-acetic acid in 250 ml of tetrahydrofuran is dropwise added thereto and the mixture is stirred at room temperature for two hours. The solvent is distilled away under reduced pressure and the residue is purified by column chromatography on silica gel (eluent: hexane:ethyl acetate = 3:1) to obtain the desired product as a colorless oily matter.

brand name

Patanol (Alcon).

Therapeutic Function

Antiallergic

References

https://www.drugbank.ca/drugs/DB00768
http://www.rxlist.com/patanol-drug/clinical-pharmacology.htm
https://en.wikipedia.org/wiki/Olopatadine

Olopatadine synthesis

113806-01-2
113806-05-6
Synthesis of Olopatadine from UGDFSHGFPJSALM-OCKHKDLRSA-N

Olopatadine Preparation Products And Raw materials

Raw materials

Preparation Products


Olopatadine Suppliers

Global( 118)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Nanjing ChemLin Chemical Industry Co., Ltd.
025-83697070
product@chemlin.com.cn CHINA 3013 60
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
Hangzhou Cyanochem Co., Ltd.
+86 17788583750
+86 571 85220831 sales@cyanochem.com CHINA 284 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
BOC Sciences
1-631-485-4226
1-631-614-7828 inquiry@bocsci.com United States 19752 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com China 47498 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Zhuozhou Wenxi import and Export Co., Ltd
+8613111626072 (WhatsApp)
Wechat: +8613111626072 Wickr me: waynehu zzwenxi@126.com CHINA 13187 58

View Lastest Price from Olopatadine manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-15 Olopatadine
113806-05-6
US $0.00 / KG 1KG 99% 200000pcs Hebei Yirun Sega Biological Technology Co. Ltd
2021-11-03 Olopatadine
113806-05-6
US $10.00 / Kg/Bag 1Kg/Bag 99% 20 Tons Hebei Zhanyao Biotechnology Co. Ltd
2021-11-02 Olopatadine
113806-05-6
US $127.00 / g 10g 99% 10T Baoji Guokang Healthchem co.,ltd

113806-05-6(Olopatadine)Related Search:


  • 11-((z)-3-(dimethyl-amino)propylidene)-6,11-dihydrodibenz[b,e]oxepin-2-acetic acid
  • Olopatatadine
  • KW 4679
  • Dibenz[b,e]oxepin-2-acetic acid, 11-[3-(dimethylamino)propylidene]-6,11-dihydro-, (11Z)-
  • Olopatadine & Olopatadine Hydrochloride
  • a-Hydroxy-Olopatadine
  • OLOPATADINE
  • -2-(11-(3-(Dimethylamino)
  • -6,11-dihydrodibenzo[b,e]oxepin-2-yl)
  • propylidene)
  • {(11Z)-11-[3-(diMethylaMino)propylidene]-6,11- dihydrodibenzo[b,e]oxepin-2-yl}acetic acid
  • (Z)-2-(11-(3-(Dimethylamino)propylidene)-6,11-dihydrodibenzo[b,e]oxepin-2-yl)acetic acid
  • Olopatadine(W.S)
  • Olopatadine Impurity E
  • 2-[(11E)-11-[3-(dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid
  • Olopatadine USP/EP/BP
  • 113806-05-6
  • C21H23NO3
  • API
  • Olopatadine
Copyright 2017 © ChemicalBook. All rights reserved