Sulfamerazine | 127-79-7

Sulfamerazine Properties

Melting point	234-238°C
Boiling point	519.1±52.0 °C(Predicted)
Density	1.3364 (rough estimate)
refractive index	1.6440 (estimate)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
pka	pKa 2.29(H2O t = 24.0 I = 0.5 (NaCl)) (Uncertain)
color	White to Off-White
Water Solubility	202mg/L(20 ºC)
Merck	14,8913
BRN	249133
CAS DataBase Reference	127-79-7(CAS DataBase Reference)
FDA 21 CFR	556.660; 558.582; 558.4
FDA UNII	UR1SAB295F
ATC code	D06BA06,J01ED07
NIST Chemistry Reference	Sulfamerazine(127-79-7)
EPA Substance Registry System	Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)- (127-79-7)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P501

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-36/37

WGK Germany

2

RTECS

WP0750000

F

10

TSCA

Yes

HS Code

2935904000

Toxicity

LD50 oral in mouse: 25gm/kg

NFPA 704

	1
0		0

Sulfamerazine price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	46826	Sulfamerazine VETRANAL , analytical standard	127-79-7	250mg	$67.5	2024-03-01	Buy
Sigma-Aldrich	1628007	Sulfamerazine United States Pharmacopeia (USP) Reference Standard	127-79-7	500mg	$381	2024-03-01	Buy
Alfa Aesar	L04194	Sulfamerazine, 98+%	127-79-7	25g	$21.8	2021-12-16	Buy
Alfa Aesar	L04194	Sulfamerazine, 98+%	127-79-7	100g	$58.4	2021-12-16	Buy
Sigma-Aldrich	S8876	Sulfamerazine ReagentPlus , ≥99.0%	127-79-7	50g	$65.3	2024-03-01	Buy

Product number	Packaging	Price	Buy
46826	250mg	$67.5	Buy
1628007	500mg	$381	Buy
L04194	25g	$21.8	Buy
L04194	100g	$58.4	Buy
S8876	50g	$65.3	Buy

Sulfamerazine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Sulfamerazine,Lederle,US,1943

Uses

Antibacterial.This compound is a contaminant of emerging concern (CECs).

Definition

ChEBI: A sulfonamide consisting of pyrimidine with a methyl substituent at the 4-position and a 4-aminobenzenesulfonamido group at the 2-position.

Manufacturing Process

To a well agitated solution of 6.95 grams of 2-amino-6-methyl pyrimidine in 40 cc of pyridine, 15 grams of p-acetylaminobenzenesulfonyl chloride are added in small portions over a 30 minute period. The reaction mixture is then heated on a steam bath for 30 minutes, the free pyridine being then removed under reduced pressure and the residue mixed with cold water, and the latter mixture is vigorously stirred. The solid reaction product is removed by filtration and washed with cold water.
There is obtained a yield of 14 grams of crude 2-(pacetylaminobenzenesulfonamido)- 6-methyl pyrimidine, which on recrystallization from alcohol and water melts at 238° to 239°C. The crude product is hydrolyzed by suspending it in 400 cc of 2 N hydrochloric acid and warming until solution is complete. The solution is neutralized with sodium carbonate and the precipitated 2-(sulfanilamido)-6-methyl pyrimidine is removed by filtration. The latter on recrystallization from alcohol and water shows a melting point of 225° to 226°C.

Therapeutic Function

Antibacterial

Antimicrobial activity

Like all examined sulfanilamides, this drug is effective in treating infections caused by streptococci, gonococci, pneumococci, staphylococci, and also colon bacillus. Synonyms of this drug are dosulfin, polagin, romezin, and others.

General Description

Chemical structure: sulfonamide

Pharmaceutical Applications

2-Sulfonamido-4-methylpyrimidine. A component of some triple sulfa combinations. Plasma half-life is c. 24 h and protein binding c. 75%. It is less active than sulfadiazine.

Safety Profile

Moderately toxic by intravenous and subcutaneous routes. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO, and SOx,.

Synthesis

Sulfamerazine, N1 -(4-methyl-2-pyrimidinyl)sulfanilamide (33.1.12), is also synthesized in the manner described above, which is by reacting 4-acetylaminobenzenesulfonyl chloride with 2-amino-4-methylpyrimidine (33.1.10), which is in turn synthesized by the traditional scheme of synthesizing derivatives of pyrimidine. Acetoacetic ester is condensed with guanidine to give 4-methyl-2-aminopyrimidin-6-one (33.1.8). Reacting this with phosphorous oxychloride gives 4-methyl-2-amino-6-chloropyrimidine (33.1.9). The chlorine atom at C6 of the pyrimidine ring is then removed by reduction with hydrogen using a palladium on carbon catalyst. The resulting 4-methyl-2-aminopyrimidine (33.1.10) is then reacted with 4-acetylaminobenzenesulfonyl chloride to make an acetanilide derivative (33.1.11), the subsequent hydrolysis of which with base leads to the formation of the desired sulfamerazine.

Synthesis_127-79-7

Sulfamerazine Preparation Products And Raw materials

Raw materials

Hydrochloric acid N-Acetylsulfanilyl chloride

Preparation Products

N-{4-[(4-methylpyrimidin-2-yl)sulfamoyl]phenyl}-4-nitrobenzamide

Sulfamerazine Suppliers

Global( 276)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd	+86-13474506593 +86-13474506593	sarah@tnjone.com	China	848	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418679 +86-18949832763	info@tnjchem.com	China	2989	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	sales@amoychem.com	China	6387	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Shaanxi Dideu Medichem Co. Ltd	18192627656	1012@dideu.com	China	3504	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

Supplier	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hefei TNJ Chemical Industry Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Xiamen AmoyChem Co., Ltd	58
Chongqing Chemdad Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Shaanxi Dideu Medichem Co. Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from Sulfamerazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-02	Sulphamerazine 127-79-7	US $0.00 / kg	1kg	99%	1000kg	Shaanxi TNJONE Pharmaceutical Co., Ltd
2024-03-16	Sulfamerazine 127-79-7	US $0.00 / KG	100g	98%+	100kg	WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-08-12	Sulfamerazine 127-79-7	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

Sulphamerazine
127-79-7
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Sulfamerazine
127-79-7
US $0.00 / KG
98%+
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

Sulfamerazine
127-79-7
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Sulfamerazine Spectrum

Sulfamerazine(127-79-7)MS Sulfamerazine(127-79-7)IR1 Sulfamerazine(127-79-7)IR2

127-79-7(Sulfamerazine)Related Search:

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DEBENAL LABOTEST-BB LT00455132 METSULFA METHYLPYRIMAL 4-METHYL-2-SULFANILAMIDO-PYRIMIDINE 4-AMINO-N-[4-METHYL-2-PYRIMIDINYL]-BENZENESULFONAMIDE 4-AMINO-N-(4-METHYL-PYRIMIDIN-2-YL)-BENZENESULFONAMIDE 2-SULFANILAMIDO-4-METHYLPYRIMIDINE SulfaMerazine ReagentPlus(R), >=99.0% Sulfamerazine Solution, 100ppm Sulfamerazine Vetec(TM) reagent grade, 98% (p-Aminobenzolsulfonyl)-2-amino-4-methylpyrimidin [German] Sulfamethyldiazine (sodium) Sulfamerazine solution,1000ppm 2(p-Aminobenzolsulfonamido)-4-methylpyrimidin Prestwick_17 SULFAMETHYLDIAZINE SULFAMERAZINE N1-(4-METHYLPYRIMIDIN-2-YL)SULFANILAMIDE PYRIMAL-M 2-Sulphanilamido-4-methylpyrimidine N1-(4-methylpyrimidin-2-yl)sulphanilamide SULFAMERAZINE PH FR-FU-USP Sulfamerazine solution SULFAMERAZINE STANDARD SOLUTION SULFAMERAZIN VETRANAL (4-AMINO-N-(4.METH SUSFAMERAZINE SULFAMERAZINE(SM1) (p-Aminobenzolsulfonyl)-2-amino-4-methylpyrimidin 2-(4-Aminobenzenesulfonamido)-4-methylpyrimidine 2-(p-Aminobenzolsulfonamido)-4-methylpyrimidine 2632 R. P. 2643-RP 2-Sulfa-4-methylpyrimidine 4-amino-n-(4-methyl-2-pyrimidinyl)-benzenesulfonamid A-310 Benzenesulfonamide, 4-amino-N-(4-methyl-2-pyrimidinyl)- benzenesulfonamide,4-amino-N-(4-methyl-2-pyrimidinyl)- component of Sulfonamide Duplex Cremomerazine Debenal-M Kelamerazine Mebacid Mesulfa Methylsulfazin Methylsulfazine Metilsulfadiazin Metilsulfazin n-(4-methyl-2-pyrimidinyl) n-(4-methyl-2-pyrimidinyl)sulfanilamide N'-(4-Methyl-2-pyrimidyl) sulfanilamide N-(4-Methyl-2-pyrimidyl)sulfanilamide n(sup1)-(4-methyl-2-pyrimidinyl)-sulfanilamid N(sup1)-(4-Methyl-2-pyrimidinyl)sulfanilamide N1-(4-Methyl-2-pyrimidinyl)sulfanilamide Percoccide Pirimal-M Pyralcid