ChemicalBook >> CAS DataBase List >>Y-27632 DIHYDROCHLORIDE

Y-27632 DIHYDROCHLORIDE

Y-27632 DIHYDROCHLORIDE structure

CAS No.: 146986-50-7

Chemical Name:: Y-27632 DIHYDROCHLORIDE

Synonyms: Y-27632;ROCK INHIBITOR;Y-276322HCl;Rock inhibitor y-27632;(1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide;CS-20;Y-27632/Y27632;Y-27632 (2HCl),98%;Y-27632, free base;Y-27632 dihydrochlor

CBNumber:: CB0699488

Molecular Formula:: C14H21N3O

Molecular Weight:: 247.34

MDL Number:: MFCD03490488

MOL File:: 146986-50-7.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:16

Request For Quotation

Y-27632 DIHYDROCHLORIDE Properties

Melting point	>260°C (dec.)
Boiling point	462.6±15.0 °C(Predicted)
Density	1.136±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,2-8°C
solubility	H₂O: 14 mg/mL
pka	13.53±0.40(Predicted)
form	solid
color	white
Stability	Hygroscopic
FDA UNII	0X370ROP6H

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H312-H332
Precautionary statements	P280
Hazard Codes	Xn
Risk Statements	20/21/22
Safety Statements	36
WGK Germany	3

Y-27632 DIHYDROCHLORIDE price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	5.09228	InSolution Y-27632, Sterile-Filtered, Cell Culture-Tested - CAS 146986-50-7 - Calbiochem	146986-50-7	2mg	$378	2024-03-01	Buy
Sigma-Aldrich	688000	Y-27632 - CAS 146986-50-7 - Calbiochem	146986-50-7	1MG	$238	2023-01-07	Buy
Sigma-Aldrich	688000	Y-27632 - CAS 146986-50-7 - Calbiochem	146986-50-7	5MG	$894	2023-01-07	Buy
Sigma-Aldrich	688000	Y-27632 - CAS 146986-50-7 - Calbiochem	146986-50-7	10MG	$1200	2023-01-07	Buy
Sigma-Aldrich	688000	Y-27632 - CAS 146986-50-7 - Calbiochem	146986-50-7	100MG	$2170	2023-01-07	Buy

Product number	Packaging	Price	Buy
5.09228	2mg	$378	Buy
688000	1MG	$238	Buy
688000	5MG	$894	Buy
688000	10MG	$1200	Buy
688000	100MG	$2170	Buy

Y-27632 DIHYDROCHLORIDE Chemical Properties,Uses,Production

Uses

Y-27632 Dihydrochloride is a salt analog of Y-27632, which is Rho-kinase inhibitor.

Definition

ChEBI: A monocarboxylic acid amide that is trans-[(1R)-1-aminoethyl]cyclohexanecarboxamide in which one of the nitrogens of the aminocarbony group is substituted by a pyridine nucleus. It has been shown to exhibit inhibitory acti ity against Rho-associated protein kinase (ROCK) enzyme.

Biological Activity

Selective inhibitor of the Rho-associated protein kinase p160ROCK. K i values are 0.14, 26, 25 and >250 μ M for p160ROCK, PKC, cAMP-dependent protein kinase and myosin light-chain kinase respectively. Also inhibits the protein kinase C-related protein kinase, PRK2 (IC 50 = 600nM). Smooth muscle relaxant and orally active in vivo . Increases survival rate of human embryonic stem (hES) cells undergoing cryopreservation.

References

[1] ishizaki t1, uehata m, tamechika i, keel j, nonomura k, maekawa m, narumiya s. pharmacological properties of y-27632, a specific inhibitor of rho-associated kinases. mol pharmacol. 2000 may;57(5):976-83.

Y-27632 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

Y-27632 DIHYDROCHLORIDE Suppliers

Global( 167)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5909	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49390	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
Hefei Hirisun Pharmatech Co., Ltd	+8615056975894	shawn@hirisunpharm.com	CHINA	9923	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
Shandong chuangyingchemical Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
AFINE CHEMICALS LIMITED	58
Finetech Industry Limited	58
Hefei Hirisun Pharmatech Co., Ltd	58

View Lastest Price from Y-27632 DIHYDROCHLORIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-08	Y-27632 DIHYDROCHLORIDE 146986-50-7	US $2.00 / KG	1g	98%MIN	ASK	Career Henan Chemical Co

Y-27632 DIHYDROCHLORIDE
146986-50-7
US $2.00 / KG
98%MIN
Career Henan Chemical Co

Y-27632 DIHYDROCHLORIDE Spectrum

Y-27632 DIHYDROCHLORIDE(146986-50-7)¹HNMR

146986-50-7(Y-27632 DIHYDROCHLORIDE)Related Search:

Y-27632 (2HCl), 5 mg Y6 Y27632 (hydrochloride) N-[(3S,4R)-6-CYANO-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-4-YL]-N-HYDROXYACETAMIDE Y320

(R)-4-(1-Aminoethyl)-N-1H-pyrrolo[2,3-b]pyridin-4-ylbenzamide (R)-4-(1-aMinoethyl)-N-(1H-pyrrolo[2,3-b]pyridin-4-yl)benzaMide dihydrochloride (R)-(+)-3-Butyn-2-ol (R)-(1-(4-nitrophenyl))ethanol Y-27632 DIHYDROCHLORIDE

1,4-Cyclohexanebis(methylamine)

1of3

(R)-(+)-TRANS-N-(4-PYRIDYL)-4-(1-AMINOETHYL)-CYCLOHEXANECARBOXAMIDE 2HCL (R)-(+)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL)CYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE (+)-R-TRANS-4-(AMINOETHYL)-N-(4-PYRIDYL)-CYCLOHEXANECARBOXAMIDE 2HCL H2O Y-27632 DIHYDROCHLORIDE TRANS-4-[(1R)-1-AMINOETHYL]-N-4-PYRIDINYLCYCLOHEXANECARBOXAMIDE DIHYDROCHLORIDE 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide dihydrochloride (1R,4r)-4-((R)-1-aMinoethyl)-N-(pyridin-4-yl)cyclohexanecarboxaMide dihydrochloride CyclohexanecarboxaMide,4-[(1R)-1-aMinoethyl]-N-4-pyridinyl-, trans- Y-27632/Y27632 Y-27632, Free Base, >99% (+)-Trans-4-[1(r)-aminoethyl]-n-(4-pyridyl)cyclohexane-1-carboxamide Y-27632 (2HCl),98% Y-27632, free base 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide 4-[(1R)-1-Aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride 4-[(1R)-1-Aminoethyl]-N-(4-pyridinyl)cyclohexanecarboxamide CS-20 4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide (+)-(R)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide (1R,4r)-4-((R)-1-aminoethyl)-N-(pyridin-4(1H)-ylidene)cyclohexanecarboxamide Y-27632 dihydrochlor ROCK INHIBITOR Y-27632 Y-276322HCl (1R,4R)-4-((R)-1-aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide Rock inhibitor y-27632 trans-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide 146986-50-7 BioChemical Cell Biology Cell Signaling and Neuroscience Kinase/Phosphatase Biology Rho Kinase (ROCK) Serine/Threonine Kinase Inhibitors Inhibitors Protein Kinase Signalling Inhibitor APIs SiChem