RO 20-1724
- CAS No.
- 29925-17-5
- Chemical Name:
- RO 20-1724
- Synonyms
- RO 20-1724;ro 20-172;R 020-1724;Ro-20-1724 - CAS 29925-17-5 - Calbiochem;4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDONE;4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE;4-(3-BUTOXY-4-METHOXY-BENZYL)IMIDAZOLIDIN-2-ONE;4-(3-BUTOXY-4-METHOXYPHENYL)METHYL-2-IMIDAZOLIDONE;4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid;4-[(3-Butoxy-4-methoxyphenyl)methyl]imidazolidin-2-one
- CBNumber:
- CB0710844
- Molecular Formula:
- C15H22N2O3
- Molecular Weight:
- 278.35
- MDL Number:
- MFCD00077397
- MOL File:
- 29925-17-5.mol
- MSDS File:
- SDS
| Boiling point | 483.8±25.0 °C(Predicted) |
|---|---|
| Density | 1.099±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | ethanol: 7 mg/mL |
| form | solid |
| pka | 14.54±0.40(Predicted) |
| color | White |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months. |
| CAS DataBase Reference | 29925-17-5(CAS DataBase Reference) |
| FDA UNII | DIW6F13QW2 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H315-H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
RO 20-1724 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B8279 | 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid | 29925-17-5 | 100mg | $111 | 2024-03-01 | Buy |
| Sigma-Aldrich | 557502 | Ro-20-1724 | 29925-17-5 | 100mg | $99.4 | 2024-03-01 | Buy |
| Cayman Chemical | 18272 | Ro 20-1724 ≥95% | 29925-17-5 | 25mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18272 | Ro 20-1724 ≥95% | 29925-17-5 | 50mg | $50 | 2024-03-01 | Buy |
| Sigma-Aldrich | B8279 | 4-(3-Butoxy-4-methoxybenzyl)imidazolidin-2-one solid | 29925-17-5 | 500mg | $512 | 2024-03-01 | Buy |
RO 20-1724 Chemical Properties,Uses,Production
Description
RO 20-1724 (29925-17-5) is a selective inhibitor of cAMP-specific phosphodiesterase (PDE4), IC50 = 0.2 μM. Displays anti-inflammatory activity. Cell permeable
Uses
Ro 20-1724 is a cell-permeable, cAMP-specific phosphodiesterase type IV (PDE4) inhibitor (IC50 = 2 μM). It weakly inhibits PDE3 with a Ki value greater than 25 μM. Ro 20-1724 inhibits the release of cytokines and other inflammatory signals as well as prevents the development of reactive oxygen species. It is often used to study cAMP-related functions in vascular cells.
Uses
Ro 20-1724 Is an inhibitor of phosphodiesterase-4, and also very effective for patients with plaque psoriasis. Selective inhibitor of cAMP-specific phosphodiesterase. Selective PDE4 inhibitor.
Definition
ChEBI: 4-[(3-butoxy-4-methoxyphenyl)methyl]-2-imidazolidinone is a member of methoxybenzenes.
Biological Activity
Widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC 50 = 2.0 μ M). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .
Biochem/physiol Actions
Inhibitor of cAMP phosphodiesterase. IC50 33 μM in vascular smooth muscle of the aorta.
storage
Store at RT
References
1) Soderling et al. (1998), Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase; Proc. Natl. Acad. Sci. USA, 95 8991 2) Nicholson et al. (1991), Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes; Trends Pharmacol. Sci., 12 19
RO 20-1724 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Mainchem Co., Ltd. | +86-0592-6210733 | sale@mainchem.com | China | 32360 | 55 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Shanghai Meishui Chemical Technology Co., Ltd | 021-60549325 18616193163 | China | 4528 | 56 |
View Lastest Price from RO 20-1724 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-08-12 | RO 20-1724
29925-17-5
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
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- RO 20-1724
29925-17-5
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd