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Diethyl 2-propylImidazoledicarbonate

Diethyl 2-propylImidazoledicarbonate structure

CAS No.: 144689-94-1

Chemical Name:: Diethyl 2-propylImidazoledicarbonate

Synonyms: OMSTint-C;Olmesartan Impurity 17;2-propyl-, diethyl ester;Intermediate of olmesartan;carbonic acid carboxy ester;4,5-diethyl-2-propyl-1H-imidazole;Diethyl 2-propylImidazoledicarbote;2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYL;Diethyl 2-propylImidazoledicarbonate;OlMesartan IMidazole Diethyl Ester IMpurity

CBNumber:: CB0712929

Molecular Formula:: C12H18N2O4

Molecular Weight:: 254.28

MDL Number:: MFCD08062365

MOL File:: 144689-94-1.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:42

Product description	Number	Pack Size	Price
Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate >98.0%(GC)(T)	D3765	5g	$42
Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate >98.0%(GC)(T)	D3765	25g	$169
Diethyl-2-propylimidazole-4,5-dicarboxylate	D444795	25g	$60
Diethyl-2-propylimidazole-4,5-dicarboxylate	FD21814	5G	$173.6
Diethyl2-Propylimidazole-4,5-dicarboxylate	OR350152	25g	$174
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Diethyl 2-propylImidazoledicarbonate Properties

Melting point	86 °C
Boiling point	400.9±25.0 °C(Predicted)
Density	1.160±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder to crystal
pka	9.25±0.10(Predicted)
color	White to Yellow to Orange
CAS DataBase Reference	144689-94-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H317-H319

Precautionary statements

P280-P305+P351+P338

HS Code

2933998090

NFPA 704

	0
2		0

Diethyl 2-propylImidazoledicarbonate price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	D3765	Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate >98.0%(GC)(T)	144689-94-1	5g	$42	2026-03-19	Buy
TCI Chemical	D3765	Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate >98.0%(GC)(T)	144689-94-1	25g	$169	2026-03-19	Buy
TRC	D444795	Diethyl-2-propylimidazole-4,5-dicarboxylate	144689-94-1	25g	$60	2021-12-16	Buy
Biosynth Carbosynth	FD21814	Diethyl-2-propylimidazole-4,5-dicarboxylate	144689-94-1	5G	$173.6	2021-12-16	Buy
Apolloscientific	OR350152	Diethyl2-Propylimidazole-4,5-dicarboxylate	144689-94-1	25g	$174	2021-12-16	Buy

Product number	Packaging	Price	Buy
D3765	5g	$42	Buy
D3765	25g	$169	Buy
D444795	25g	$60	Buy
FD21814	5G	$173.6	Buy
OR350152	25g	$174	Buy

Diethyl 2-propylImidazoledicarbonate Chemical Properties,Uses,Production

Uses

Diethyl 2-propylImidazoledicarbonate is an intermediate in the synthesis of Olmesartan Medoxomil.

Chemical Properties

Light Yellow Solid

Uses

An intermediate in the synthesis of Olmesartan Medoxomil. (O550000)

Synthesis

2-Propyl-1H-imidazole-4,5-dicarboxy acid

58954-23-7

64-17-5

144689-94-1

General procedure for the synthesis of diethyl 2-propyl-4,5-imidazoledicarboxylate from 2-propyl-1H-imidazole-4,5-dicarboxylic acid and ethanol: 48 mmol of 2-n-propylimidazole-4,5-dicarboxylic acid (synthesized in Example 3) was added to a four-necked flask with 152 mL of ethanol. 20.22 g (165 mmol) of thionyl chloride was added slowly dropwise at liquid temperature over 1 hour and 40 minutes. Subsequently 0.91 g (51 mmol) of water was added and the reaction solution was cooled to room temperature. The reaction mixture was heated to reflux for 5 hours (liquid temperature: 74 °C to room temperature). Upon completion of the reaction, the precipitated inorganic salt was removed by filtration. The filtrate was concentrated and partitioned for extraction by adding 50 mL of ethyl acetate and 60 mL of saturated aqueous sodium bicarbonate. After adjusting the pH of the aqueous layer to 7, 20 mL of ethyl acetate was added. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the crude product of diethyl 2-propyl-4,5-imidazoledicarboxylate. To the crude product, 13.06 g of ethyl acetate and 1.07 g of ethanol were added, concentrated to a product weight of 14.5 g and crystallized. After filtration, it was dried under vacuum at 50°C to obtain diethyl 2-propyl-4,5-imidazoledicarboxylate. The first to third crystals were obtained sequentially by recrystallizing the mother liquor and repeating the recrystallization process according to the same method as in Example 1. By HPLC analysis, the yield was 9.50 g (77%) and the HPLC purity was 99.7% for the first crystal, 99.7% for the second crystal and 99.0% for the third crystal, respectively.

References

[1] Organic Preparations and Procedures International, 2006, vol. 38, # 4, p. 410 - 412
[2] Journal of Medicinal Chemistry, 1996, vol. 39, # 1, p. 323 - 338
[3] Patent: JP5688696, 2015, B2. Location in patent: Paragraph 0097

Diethyl 2-propylImidazoledicarbonate Preparation Products And Raw materials

Raw materials

2-Propyl-1H-imidazole-4,5-dicarboxy acid Butyramidine hydrochloride 2-CHLORO-3-OXO-SUCCINIC ACID DIETHYL ESTER Ethanol Thionyl chloride

Preparation Products

4-(1-Hydroxy-1-methylpropyl)-2-propyl-1H-Imidazole-5-carboxylic acidethylester Trityl Olmesartan Medoxomil diethyl 2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4,5-dicarboxylate 1H-Imidazole-5-carboxylic acid, 4-(1-ethyl-1-hydroxypropyl)-2-propyl-, ethyl ester

Diethyl 2-propylImidazoledicarbonate Suppliers

Global( 300)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21592	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29821	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	10000	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Standardpharm Co. Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from Diethyl 2-propylImidazoledicarbonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-21	Diethyl 2-propylImidazoledicarbonate 144689-94-1	US $0.00-0.00 / Kg/Drum	1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-03-12	Olmesartan Medoxomil Impurity 27 144689-94-1	US $0.00-0.00 / mg	10mg	98%	500mg	ShenZhen H&D Pharmaceutical Technology Co., LTD
2025-12-01	Diethyl 2-propylImidazoledicarbonate 144689-94-1	US $0.00 / kg	1kg	98%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

Diethyl 2-propylImidazoledicarbonate
144689-94-1
US $0.00-0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Olmesartan Medoxomil Impurity 27
144689-94-1
US $0.00-0.00 / mg
98%
ShenZhen H&D Pharmaceutical Technology Co., LTD

Diethyl 2-propylImidazoledicarbonate
144689-94-1
US $0.00 / kg
98%
Shaanxi Dideu New Materials Co. Ltd

Diethyl 2-propylImidazoledicarbonate Spectrum

Diethyl 2-propylImidazoledicarbonate(144689-94-1)¹HNMR

144689-94-1(Diethyl 2-propylImidazoledicarbonate)Related Search:

2-Propyl-1H-imidazole-4,5-dicarboxy acid OlMesartan Lactone IMpurity 1-(4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazol-5-yl)ethanone 4-(1-Methoxy-1-methylethyl)-2-propyl-1H-Imidazole-5-carboxylic acid ethyl ester OlMesartan Ethyl Ester IMpurity

3,6-Dihydro-6,6-diMethyl-2-propyl-3-[[2'-[2-(triphenylMethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]Methyl]-4H-furo[3,4-d]iMidazol-4-one Olmesartan medoxomil impurity I Ethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-imidazole-5-carboxylate Trityl olMesartan MedoxoMil iMpurity II OlMesartan Methyl Ester

OlMesartan interMediate iMpurity II OlMesartan MedoxoMil Butyl IMpurity Olmesartan Impurity 12 5-[4'-(Bromomethyl)-[1,1'-biphenyl]-2-yl]-2-(triphenylmethyl)-2H-tetrazole 4,5-Dimethyl-1,3-dioxol-2-one

4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid Olmesartan Olmesartan Impurity 10

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2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYL 2-Propylimidazoledicarboxylic acid diethyl ester 2-PROPYL-4,5-IMIDAZOLEDICARBOXYLIC ACID DIETHYL ESTER 98.0% 2-propyl-, diethyl ester 1H-Imidazole-4,5-dicarboxylic acid, 2-propyl-, 4,5-diethyl ester 2-proyl-4,5-imidazoledicarboxylic acid diethyl ester 4,5-diethyl 2-propyl-1H-iMidazole-4,5-dicarboxylate 2-Propyl-1H-iMidazole-4,5-dicarboxylic Acid 4,5-Diethyl Ester OlMesartan IMidazole Diethyl Ester IMpurity 2-Propyl-1H-imidazol-4,5-dicarboxylic acid 4,5-diethyl ester 2-propy-1H-imidazole-4,5-dicarboxylic acid diethyl ester Diethyl 2-Propyl-1H-imidazole-4,5-dicarboxylate Diethyl 2-propylImidazoledicarbote 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXY ACID DIETHYL ESTER 2-PROPYL-1H-IMIDAZOLE-4, 5-DICARBOXYLIC ACID DIETHYL ESTER 1H-IMIDAZOLE-4, 5-DICARBOXYLIC ACID,2-PROPYL-DIETHYL ESTER DIETHYL 2-PROPYL-1H-IMIDAZOLE-4,5-DICARBOXYLATE Diethyl 2-propylImidazoledicarbonate 2-propyl-1H-imidazole-4,5-dicarboxyaciddiethyl 4,5-diethyl-2-propyl-1H-imidazole carbonic acid carboxy ester Diethyl 2-Propyl-1H-Imidazole-4,5-Dicarboxylat Olmesartan Impurity 17 OMSTint-C Diethyl2-Propyl-1H-imidazole-4,5-dicarboxylate> Diethyl 2-propylImidazoledicarbonate USP/EP/BP Diethyl 2-propyl-1H-imidazole-4,5-dicarboxylate Molecular Formula: C12H18N2O4 Molecular Weight: 254.28 Olmesartan Imidazole Diethyl Ester Impurity 2-Propyl-1H-imidazole-4,5-dicarboxylic acid diethyl ester Intermediate of olmesartan 144689-94-1 C12H18O4N2 Aromatics Intermediates Organic acids Pharmaceutical material and intermeidates