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Benzalkonium chloride

Benzalkonium chloride
Benzalkonium chloride structure
CAS No.
8001-54-5
Chemical Name:
Benzalkonium chloride
Synonyms
BAK;BAC;BKC;Osvan;Welpas;DIMANIN;ZEPHARIN;ZEPHIRAN;264-151-6;Parasterol
CBNumber:
CB0712969
Molecular Formula:
C17H30ClN
Formula Weight:
283.88
MOL File:
8001-54-5.mol

Benzalkonium chloride Properties

Boiling point:
>100°C/760mmHg
Density 
0.98
storage temp. 
2-8°C
solubility 
Very soluble in water and in ethanol (96 per cent). An aqueous solution froths copiously when shaken.
form 
Viscous Solution
Specific Gravity
0.98
color 
Clear or white to yellow, may contain yellow-white fragments
Stability:
Stable. Incompatible with strong oxidizing agents, moisture. Hygroscopic.
CAS DataBase Reference
8001-54-5(CAS DataBase Reference)
FDA UNII
7N6JUD5X6Y
EPA Substance Registry System
Benzalkonium chloride (8001-54-5)
SAFETY
  • Risk and Safety Statements
Hazard Codes  C,N
Risk Statements  21/22-34-50
Safety Statements  36/37/39-45-61
RIDADR  UN 3261 8/PG 3
WGK Germany  3
RTECS  BO3151000
3-9
HS Code  34021200
Toxicity LD50 orally in rats: 400 mg/kg (Cummins, Kimura)

Benzalkonium chloride price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR1681 Benzalkonium Chloride 50% Solution Pharmaceutical Secondary Standard; Certified Reference Material 1 mL $80.2 2021-03-22 Buy

Benzalkonium chloride Chemical Properties,Uses,Production

Description

Benzalkonium chloride is a quaternary ammonium mixture of alkyl, dimethyl and benzyl ammonium chlorides.It is an irritant rather than a sensitizer, but may cause contact dermatitis in nursing and medical personnel. An unusual case was reported in a farm worker who used a detergent containing benzalkonium chloride to clean the piggery.

Chemical Properties

Benzalkonium chloride occurs as a white or yellowish-white amorphous powder, a thick gel, or gelatinous flakes. It is hygroscopic, soapy to the touch, and has a mild aromatic odor and very bitter taste.

Chemical Properties

white or light yellow/grey solid, or colourless aqueous solution

Uses

antiarthritic, cyclooxygenase2 inhibitor

Uses

benzalkonium chloride is a preservative with anti-microbial and deodorant properties. It can also be used as a surfactant. With continuous use, it may cause occasional allergic reactions.

Uses

Cationic surface active agent and germicide. Pharmaceutic aid (preservative). Algicide.

Definition

ChEBI: A class of quaternary ammonium chloride salts in which the nitrogen is substituted by a benzyl group, two methyl groups and an even-numbered alkyl chain.

Production Methods

Benzalkonium chloride is formed by the reaction of a solution of Nalkyl- N-methylbenzamine with methyl chloride in an organic solvent suitable for precipitating the quaternary compound as it is formed.

brand name

Roccal (Sterling Winthrop); Zephiran Chloride (Sterling Winthrop).

Hazard

Highly toxic; poison.

Agricultural Uses

Biocide, Algaecide, Fungicide: Used as an algaecide to control slime mold, algae, fish pathogens, and mollusks in ponds, canals and bodies of water. Also widely used in deodorants, detergents, sanitizers and germicides for applications in food plants, laundries, and operating rooms. Not listed for use in EU countries . Registered for use in the U.S. but not California.

Pharmaceutical Applications

Benzalkonium chloride is a quaternary ammonium compound used in pharmaceutical formulations as an antimicrobial preservative in applications similar to other cationic surfactants, such as cetrimide. In ophthalmic preparations, benzalkonium chloride is one of the most widely used preservatives,at a concentration of 0.01–0.02% w/v. Often it is used in combination with other preservatives or excipients, particularly 0.1% w/v disodium edetate, to enhance its antimicrobial activity against strains of Pseudomonas.
In nasal, and otic formulations a concentration of 0.002–0.02% w/v is used, sometimes in combination with 0.002–0.005% w/v thimerosal. Benzalkonium chloride 0.01% w/v is also employed as a preservative in small-volume parenteral products. Benzalkonium chloride was also shown to enhance the topical penetration of lorazepam.
Benzalkonium chloride is additionally used as a preservative in cosmetics.

Trade name

AMMONYX®; ARQUAD DMMCB-75®; BARQUAT® MB-50; BARQUAT® MB-80; BAYCLEAN®; BIO-QUAT 50-24®; CATAMINE® AB; CONSAN®; DRAPOLENE®; GARDIQUAT®-1450; HYAMINE®-3500; INTEXAN® LB-50; KATAMINE® AB; NEO GERM-I-TOL®; ONYX BTC; OSVAN; RODALON®; SENTINEL®; TRITON® K-60; VIKROL® RQ

Contact allergens

This quaternary ammonium cationic surfactant is a mixture of alkyl, dimethyl, and benzyl ammonium chlorides (-R). It is an irritant rather than a sensitizer, but may cause allergic contact dermatitis from creams, detergents/antiseptics, ophthalmic preparations, and in nursing, veterinary, dental, and medical personnel. Its presence was observed in plaster of Paris.

Clinical Use

Alkylbenzyldimethylammonium chloride (Zephiran) is a mixtureof alkylbenzyldimethylammonium chlorides of the generalformula [C6H5CH2N(CH3)2R] Cl , where R represents amixture of alkyl chains beginning with C8H17 and extendingto higher homologues with C12H25, C14H29, and C16H33. The higher–molecular-weight homologues compose the majorfractions. Although variations in the physical and antimicrobialproperties exist between individual members of the mixture,they are of little importance in the chemistry of the overallproduct. Benzalkonium chloride occurs as a white gel thatis soluble in water, alcohol, and organic solvents. Aqueous solutionsare colorless, slightly alkaline, and very foamy.
Benzalkonium chloride is a detergent, an emulsifier, anda wetting agent. It is used as an antiseptic for skin and mucousmembranes in concentrations of 1:750 to 1:20,000. Forirrigation, 1:20,000 to 1:40,000 concentrations are used. Forstorage of surgical instruments, 1:750 to 1:5,000 concentrationsare used, with 0.5% NaNO3 added as a preservative.

Safety

is well tolerated in the dilutions normally employed on the skin and mucous membranes. However, benzalkonium chloride has been associated with adverse effects when used in some pharmaceutical formulations.
Ototoxicity can occur when benzalkonium chloride is applied to the ear and prolonged contact with the skin can occasionally cause irritation and hypersensitivity. Benzalkonium chloride is also known to cause bronchoconstriction in some asthmatics when used in nebulizer solutions.
Toxicity experiments with rabbits have shown benzalkonium chloride to be harmful to the eye in concentrations higher than that normally used as a preservative. However, the human eye appears to be less affected than the rabbit eye and many ophthalmic products have been formulated with benzalkonium chloride 0.01% w/v as the preservative.
Benzalkonium chloride is not suitable for use as a preservative in solutions used for storing and washing hydrophilic soft contact lenses, as the benzalkonium chloride can bind to the lenses and may later produce ocular toxicity when the lenses are worn. Solutions stronger than 0.03% w/v concentration entering the eye require prompt medical attention.
Local irritation of the throat, esophagus, stomach, and intestine can occur following contact with strong solutions (>0.1% w/v). The fatal oral dose of benzalkonium chloride in humans is estimated to be 1–3 g. Adverse effects following oral ingestion include vomiting, collapse, and coma. Toxic doses lead to paralysis of the respiratory muscles, dyspnea, and cyanosis.
LD50 (mouse, oral): 150 mg/kg
LD50 (rat, IP): 14.5 mg/kg
LD50 (rat, IV): 13.9 mg/kg
LD50 (rat, oral): 300 mg/kg
LD50 (rat, skin): 1.42 g/kg

storage

Benzalkonium chloride is hygroscopic and may be affected by light, air, and metals.
Solutions are stable over a wide pH and temperature range and may be sterilized by autoclaving without loss of effectiveness. Solutions may be stored for prolonged periods at room temperature. Dilute solutions stored in polyvinyl chloride or polyurethane foam containers may lose antimicrobial activity.
The bulk material should be stored in an airtight container, protected from light and contact with metals, in a cool, dry place.

Incompatibilities

Incompatible with aluminum, anionic surfactants, citrates, cotton, fluorescein, hydrogen peroxide, hypromellose,iodides, kaolin, lanolin, nitrates, nonionic surfactants in high concentration, permanganates, protein, salicylates, silver salts, soaps, sulfonamides, tartrates, zinc oxide, zinc sulfate, some rubber mixes, and some plastic mixes.
Benzalkonium chloride has been shown to be adsorbed to various filtering membranes, especially those that are hydrophobic or anionic.

Regulatory Status

Included in the FDA Inactive Ingredients Database (inhalations, IM injections, nasal, ophthalmic, otic, and topical preparations). Included in nonparenteral medicines licensed in the UK. It is also included in the Canadian List of Acceptable Non-medicinal Ingredients.

Benzalkonium chloride Preparation Products And Raw materials

Raw materials

Preparation Products


Benzalkonium chloride Suppliers

Global( 302)Suppliers
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JingJiang Connect Chemical manufacturing Co., Ltd.
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View Lastest Price from Benzalkonium chloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-06-22 Benzalkonium chloride
8001-54-5
US $12.00 / KG 1KG 50 .80 .95% 10T Henan Xiangtong Chemical Co., Ltd.
2020-12-31 Benzalkonium chloride
8001-54-5
US $5.00-100.00 / KG 0.5KG >99% 20tons Anhui Rencheng Technology Co., Ltd
2021-04-22 Benzalkonium chloride
8001-54-5
US $50.00 / Kg 1KG 99% 100ton Shanghai Yunao International Trade Co., Ltd

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