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Boc-D-Serine

Boc-D-Serine structure

CAS No.: 6368-20-3

Chemical Name:: Boc-D-Serine

Synonyms: (tert-Butoxycarbonyl)-D-serine;BOC-D-SER-OH;Boc-D-Ser;N-BOC-D-SERINE;OC-D-Serine;BOC-D-SERINE;BOC-D-SERINE H2O;N-T-BOC-D-SERINE;BOC-D-Serine,98%;Bok - D - serine

CBNumber:: CB0718613

Molecular Formula:: C8H15NO5

Molecular Weight:: 205.21

MDL Number:: MFCD00063142

MOL File:: 6368-20-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-12 09:20:59

Product description	Number	Pack Size	Price
Boc-D-Ser-OH Novabiochem?	8.53096	25g	$551
N-(tert-Butoxycarbonyl)-D-serine >98.0%(HPLC)(T)	B2258	1g	$22
N-(tert-Butoxycarbonyl)-D-serine >98.0%(HPLC)(T)	B2258	5g	$41
(tert-Butoxycarbonyl)-D-serine >98%	B67481	100g	$25
(tert-Butoxycarbonyl)-D-serine >98%	B67481	500g	$100
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Boc-D-Serine Properties

Melting point	91-95 °C(lit.)
alpha	8.5 º (c=1 H2O)
Boiling point	343.88°C (rough estimate)
Density	1.2977 (rough estimate)
refractive index	1.4540 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	3.62±0.10(Predicted)
color	White
optical activity	13.09°(C=0.4243g/100mI, DMF, 20°C, 589nm)
Water Solubility	almost transparency
BRN	1874714
Major Application	peptide synthesis
InChI	InChI=1S/C8H15NO5/c1-8(2,3)14-7(13)9-5(4-10)6(11)12/h5,10H,4H2,1-3H3,(H,9,13)(H,11,12)/t5-/m1/s1
InChIKey	FHOAKXBXYSJBGX-RXMQYKEDSA-N
SMILES	C(O)(=O)[C@@H](CO)NC(OC(C)(C)C)=O
CAS DataBase Reference	6368-20-3(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS08

Signal word

Danger

Hazard statements

H301-H311-H331-H341

Precautionary statements

P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501

PPE

Eyeshields, Gloves, type N95 (US)

Safety Statements

24/25

WGK Germany

HS Code

29241990

Storage Class

13 - Non Combustible Solids

REACH Registrations

Active

NFPA 704

	0
0		0

Boc-D-Serine price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53096	Boc-D-Ser-OH Novabiochem?	6368-20-3	25g	$551	2026-04-30	Buy
TCI Chemical	B2258	N-(tert-Butoxycarbonyl)-D-serine >98.0%(HPLC)(T)	6368-20-3	1g	$22	2026-04-30	Buy
TCI Chemical	B2258	N-(tert-Butoxycarbonyl)-D-serine >98.0%(HPLC)(T)	6368-20-3	5g	$41	2026-04-30	Buy
Synthonix	B67481	(tert-Butoxycarbonyl)-D-serine >98%	6368-20-3	100g	$25	2026-05-06	Buy
Synthonix	B67481	(tert-Butoxycarbonyl)-D-serine >98%	6368-20-3	500g	$100	2026-05-06	Buy

Product number	Packaging	Price	Buy
8.53096	25g	$551	Buy
B2258	1g	$22	Buy
B2258	5g	$41	Buy
B67481	100g	$25	Buy
B67481	500g	$100	Buy

Boc-D-Serine Chemical Properties,Uses,Production

Chemical Properties

White powder

Uses

Boc-D-serine is D-serine (S270975) with amine protected from eletrophiles by tert-butyloxycarbonyl group in organic synthesis. Boc-D-serine can be used to synthesize acetamido-methoxypropionamides such as Desacetyl Desmethyl Lacosamide (D288325) which is a potent anticonvulsant.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

312-84-5

24424-99-5

3262-72-4

1. An aqueous solution of sodium hydroxide (8.4 g, 0.110 mol) was prepared by dissolving sodium hydroxide (8.4 g, 0.110 mol) in water (53 mL) at room temperature. 2. The above solution was cooled down to 5-10 °C. 3. To the cooled aqueous solution of sodium hydroxide was added sequentially D-serine (10.5 g, 0.100 mol) and di-tert-butyl dicarbonate (26.2 g, 0.120 mol), while the temperature was maintained at ≤ 10 °C. 4. 26.2 g, 0.120 mol). 4. The reaction mixture was heated to 30-35 °C and stirred at this temperature for 20 h. 5. Upon completion of the reaction, an aqueous solution of compound I (BOC-L-serine) was obtained in 100% yield, with 99.1% HPLC purity and 99.4% chiral purity. 6. The aqueous solution of compound I did not need to be further purified and could be used directly in the subsequent synthetic step. 7. The aqueous solution of compound I can be used directly in the subsequent synthesis steps.

References

[1] Journal of the American Chemical Society, 1994, vol. 116, # 18, p. 8402 - 8403
[2] Journal of the American Chemical Society, 2008, vol. 130, # 7, p. 2351 - 2364
[3] Advanced Synthesis and Catalysis, 2016, vol. 358, # 1, p. 34 - 40
[4] Patent: CN104030943, 2016, B. Location in patent: Paragraph 0095; 0096
[5] Beilstein Journal of Organic Chemistry, 2014, vol. 10, p. 1114 - 1120

Boc-D-Serine Preparation Products And Raw materials

Raw materials

D-Serine Di-tert-butyl dicarbonate Sodium hydroxide

Preparation Products

BOC-3-IODO-D-ALANINE BENZYL ESTER

Boc-D-Serine Suppliers

Global( 456)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20124	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Taizhou Tianhong Biochemistry Technology Co., Ltd.	0523-86132544	sales@thbiochem.com	CHINA	305	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21588	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
AB PharmaTech,LLC	323-480-4688	sales@acrospharmatech.com	United States	989	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29817	58
Jinan Shengqi pharmaceutical Co,Ltd	86+18663751872	christine@shengqipharm.com	CHINA	491	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6367	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Taizhou Tianhong Biochemistry Technology Co., Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
AB PharmaTech,LLC	55
career henan chemical co	58
Jinan Shengqi pharmaceutical Co,Ltd	58
Xiamen AmoyChem Co., Ltd	58
Shandong chuangyingchemical Co., Ltd.	58

View Lastest Price from Boc-D-Serine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-18	Boc-D-Serine 6368-20-3	US $0.00 / Kg/Drum	1KG	98%min	1000kg	WUHAN FORTUNA CHEMICAL CO., LTD
2025-09-25	Boc-D-Serine 6368-20-3	US $5.00-0.10 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-09-14	Boc-D-Serine 6368-20-3	US $0.00-0.00 / g	100g	99%	20 tons	Wuhan Han Sheng New Material Technology Co.，Ltd

Boc-D-Serine
6368-20-3
US $0.00 / Kg/Drum
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Boc-D-Serine
6368-20-3
US $5.00-0.10 / KG
99%
Henan Fengda Chemical Co., Ltd

Boc-D-Serine
6368-20-3
US $0.00-0.00 / g
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

Boc-D-Serine Spectrum

Boc-D-Serine(6368-20-3)¹HNMR

6368-20-3(Boc-D-Serine)Related Search:

N-Carbobenzyloxyglycine L-CYCLOSERINE L-Homoserine L-Serine L-ALPHA-PHOSPHATIDYLSERINES, BRAIN, BOVINE

D-Cycloserine D-Serine DL-Serine L-Valine methyl ester hydrochloride D-Valine

tert-Butanol DIMETHYL (BOC-AMINO)MALONATE N-BOC-O-Benzyl-L-serine DIETHYL (BOC-AMINO)MALONATE N-(tert-Butoxycarbonyl)-O-benzyl-D-threonine

BOC-D-THR-OH BOC-D-SERINE METHYL ESTER,BOC-D-SERINE METHYLESTER OIL,N-BOC-D-serine methylester Boc-O-tert-butyl-L-serine

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BOC-D-SERINE H2O BOC-D-SERINE N-(TERT-BUTOXYCARBONYL)-D-SERIN N-(TERT-BUTOXYCARBONYL)-D-SERINE N-T-BOC-D-SERINE N-ALPHA-T-BUTOXYCARBONYL-D-SERINE N-ALPHA-TERT-BUTYLOXYCARBONYL-D-SERINE N-ALPHA-T-BOC-D-SERINE D-Serine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI) OC-D-Serine N-ALPHA-T-BUTYLOXYCARBONYL-D-SERINE Boc-D-Serine (amhydrons) N-Boc-D-serine, 98+% BOC-D-SERINE extrapure N-(tert-Butoxycarbonyl)-D-serine, N-t-Boc-D-Serine, Boc-D-Ser-OH (R)-2-[(tert-Butyloxycarbonyl)amino]-3-hydroxypropanoic acid N-(tert-Butyloxycarbonyl)-D-serine BOC-D-Serine,98% (R)-Boc-2-amino-3-hydroxypropionic acid Boc-D-serine≥ 99% (HPLC) Boc-D-β-hydroxyalanine N-Boc-D-serine,99%e.e. N-Boc-D-serine Boc-D-Ser-OH Boc-D-Ser-OH (Boc-D-Serine) D-Serine,N-[(1,1-diMethylethoxy)carbonyl]- Boc-D-Ser-OH >=98.0% (TLC) Boc-D-Ser-OH monohydrate (R)-tert-Butoxycarbonyl-D-Serine N-Boc-D-serine,Lacosamide (2R)-2-{[(tert-butoxy)carbonyl]amino}-3-hydroxypropanoic acid (Tert-Butoxy)Carbonyl D-Ser-OH N-(tert-Butoxycarbonyl)-D-serine > (2R)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoicaci Bok - D - serine N-(tert-Butoxycarbonyl)-D-serineN- BOC-D-SER-OH N-BOC-D-SERINE Boc-D-Ser (tert-Butoxycarbonyl)-D-serine N-[(1,1-Dimethylethoxy)carbonyl]-D-serine (R)-2-tert-butoxycarbonylamino-3-hydroxy propionic acid Boc-D-Ser-OH 6368-20-3 HOCH2CHNHCO2CCH33CO2H C8H14NO5 CARBOXYLIC ACID Amino Acid Derivatives Peptide Synthesis Serine Specialty Synthesis Boc-Amino Acids Protected & Labeled Amino Acids Amino Acids (N-Protected) Boc-Amino Acids and Derivative AMINOACIDS DERIVATIVES Amino Acids N-BOC Amino Acids (N-Protected)