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2,4-Difluoronitrobenzene

2,4-Difluoronitrobenzene Structure
2,4-Difluoronitrobenzene structure
CAS No.
446-35-5
Chemical Name:
2,4-Difluoronitrobenzene
Synonyms
2,4-DIFLUORO-1-NITROBENZENE;2.4 DFNB;2,4-Difluoronitroben;3,5-diflurobenzonitrile;2,4-Difluronitrobenzene;2,4-Difluoronitribenzene;2,4-DIFLUORO NITROBENZEN;2,4-DIFLUORONITROBENZENE;Flurbiprofen Impurity 24;1,3-Difluor-4-nitrobenzol
CBNumber:
CB0722917
Molecular Formula:
C6H3F2NO2
Molecular Weight:
159.09
MDL Number:
MFCD00007050
MOL File:
446-35-5.mol
MSDS File:
SDS
Last updated:2025-09-25 17:15:13
Product description Number Pack Size Price
2,4-Difluoronitrobenzene 99% 233226 25g $32.87
2,4-Difluoronitrobenzene 99% 233226 100g $120.65
2,4-Difluoronitrobenzene >99.0%(GC) D1636 25g $22
2,4-Difluoronitrobenzene >99.0%(GC) D1636 500g $147
2,​4-​Difluoronitrobenzene D447530 1000g $745
More product size
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2,4-Difluoronitrobenzene Properties

Melting point 9-10 °C (lit.)
Boiling point 203-204 °C (lit.)
Density 1.451 g/mL at 25 °C (lit.)
vapor density >1 (vs air)
refractive index n20/D 1.511(lit.)
Flash point 195 °F
storage temp. Sealed in dry,Room Temperature
form clear liquid
color Light yellow to Brown
Specific Gravity 1.45
Water Solubility Insoluble in water.
BRN 2048034
Stability Stable. Incompatible with strong bases, strong oxidizing agents. Combustible.
InChIKey RJXOVESYJFXCGI-UHFFFAOYSA-N
CAS DataBase Reference 446-35-5(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 6398Y1D7JS
NIST Chemistry Reference 2,4-Difluoronitrobenzene(446-35-5)
EPA Substance Registry System 2,4-Difluoronitrobenzene (446-35-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319-H335
Precautionary statements  P301+P310+P330-P302+P352-P305+P351+P338
Hazard Codes  T,Xi,Xn
Risk Statements  25-36/37/38-23/24/25-20/21/22
Safety Statements  26-45-36/37/39-23
RIDADR  UN 2810 6.1/PG 1
WGK Germany  3
RTECS  CZ5730000
Hazard Note  Irritant
TSCA  T
HazardClass  6.1
PackingGroup  III
HS Code  29049090
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

2,4-Difluoronitrobenzene price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 233226 2,4-Difluoronitrobenzene 99% 446-35-5 25g $32.87 2025-07-31 Buy
Sigma-Aldrich 233226 2,4-Difluoronitrobenzene 99% 446-35-5 100g $120.65 2025-07-31 Buy
TCI Chemical D1636 2,4-Difluoronitrobenzene >99.0%(GC) 446-35-5 25g $22 2025-07-31 Buy
TCI Chemical D1636 2,4-Difluoronitrobenzene >99.0%(GC) 446-35-5 500g $147 2025-07-31 Buy
TRC D447530 2,​4-​Difluoronitrobenzene 446-35-5 1000g $745 2021-12-16 Buy
Product number Packaging Price Buy
233226 25g $32.87 Buy
233226 100g $120.65 Buy
D1636 25g $22 Buy
D1636 500g $147 Buy
D447530 1000g $745 Buy

2,4-Difluoronitrobenzene Chemical Properties,Uses,Production

Synthesis

KF with n-Hexadecyltrimethylammonium bromide as the PTC has been shown recently to work in dimethylformamide (DMF), important owing to the low cost16 of DMF.Synthesis of 2,4-Difluoronitrobenzene

Chemical Properties

yellow liquid

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction, (±)-horsfiline and resin-bound-2-arylaminobenzimidazoles.

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of: 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction; (±)-horsfiline; resin-bound 2-arylaminobenzimidazoles.
2,?4-?Difluoronitrobenzene is a reactant in the preparation of 4-?thiazolidinone derivatives as antimicrobial agents.

Uses

2,4-Difluoronitrobenzene has been used in the synthesis of:

  • 2,4-difluoro-5-nitrobenzenesulfonic acid via sulfonation reaction
  • (±)-horsfiline
  • resin-bound 2-arylaminobenzimidazoles

General Description

Nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine has been investigated using flow reactor with simulated moving bed (SMB) chromatography module.

References

[1] Catalysis Today, 2012, vol. 198, # 1, p. 300 - 304
[2] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 8
[3] Patent: US2009/99387, 2009, A1. Location in patent: Page/Page column 7-9
[4] Tetrahedron, 1995, vol. 51, # 22, p. 6363 - 6376
[5] Journal of the American Chemical Society, 1956, vol. 78, p. 6034,6037

2,4-Difluoronitrobenzene Preparation Products And Raw materials

Raw materials

1,3-Difluorobenzene tetrakis(N,N-DIethylaMino)phosphorus broMide Tetrabutylphosphonium bromide Potassium fluoride TRIHEXYL(TETRADECYL)PHOSPHONIUM TETRAFLUOROBORATE
Dimethyl sulfoxide 2,4-Dichloronitrobenzene

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Preparation Products

5-Fluoro-2-oxindole 2,4-Difluoroaniline 3-Fluoro-4-nitroanisole 3-Fluoro-4-nitroaniline 1,5-Difluoro-2,4-dinitrobenzene
2,6-Difluoronitrobenzene 2-Chloro-4-fluoronitrobenzene 1-Fluoro-3-nitrobenzene

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2,4-Difluoronitrobenzene Suppliers

Global( 504)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5249 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20136 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29735 60
Hi-Tech Chemistry Corp 		0519-86626038 yuhh@hitechem.com CHINA 810 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21612 55
Shanghai Time Chemicals CO., Ltd. 		+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1803 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29847 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10405 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2952 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co,.LTD 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Hi-Tech Chemistry Corp 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Shanghai Time Chemicals CO., Ltd. 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Jinan Finer Chemical Co., Ltd 		58

View Lastest Price from 2,4-Difluoronitrobenzene manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2,4-Difluoronitrobenzene pictures 2025-12-01 2,4-Difluoronitrobenzene
446-35-5
 US $0.00 / kg 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
2,4-Difluoronitrobenzene pictures 2025-09-25 2,4-Difluoronitrobenzene
446-35-5
 US $9.00-0.90 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd
2,4-Difluoronitrobenzene pictures 2025-05-26 2,4-Difluoronitrobenzene
446-35-5
 US $10.00 / KG 1KG 99.% 10 ton Hebei Chuanghai Biotechnology Co,.LTD

2,4-Difluoronitrobenzene Spectrum

2,4-Difluoronitrobenzene(446-35-5)MS2,4-Difluoronitrobenzene(446-35-5)1HNMR2,4-Difluoronitrobenzene(446-35-5)13CNMR2,4-Difluoronitrobenzene(446-35-5)IR12,4-Difluoronitrobenzene(446-35-5)Raman

446-35-5(2,4-Difluoronitrobenzene)Related Search:

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2,4-Difluorobiphenyl diethyl (3-fluoro-4-nitrophenyl)methylmalonate 4'-hydroxyflurbiprofen 2-Fluorobiphenyl-4-carboxylic Acid Flurbiprofen Impurity
Flurbiprofen Related Impurity 1 4-ETHYL-2-FLUORO-1,1'-BIPHENYL diethyl (4-amino-3-fluorophenyl)methylmalonate Flurbiprofen Impurity 16 (2-FLUORO-4-BIPHENYL)ACETIC ACID
α-Hydroxy Flurbiprofen 2-Methylpropanedioic acid 3-Fluoro-4-phenylphenol

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1,3-difluoro-4-nitrobenzene 1-Nitro-2,4-difluorobenzene 2,4-difluoro-1-nitro-benzen 2,4-Difluronitrobenzene Benzene, 2,4-difluoro-1-nitro- 2,4-DIFLUORONITROBENZENE 2,4-DIFLUORO NITROBENZEN 2,4-Difluoronitribenzene Benzene, 2,4-difluoro-1-nitro- (6CI,7CI,8CI,9CI) 3,5-diflurobenzonitrile 2,4-DIFLUORONITROBENZENE =99%(HPLC) 2,4-Difluoronitroben 2.4 DFNB 2,4-Difluoronitrobenzene14 2, 4-2 fluoro nitrobenzene 2,4-Difluoronitrobenzene99% 1,3-Difluor-4-nitrobenzol 2,4-Difluoronitrobenzene> 2,4-Difluoronitrobenzene,>98% Flurbiprofen Impurity 24 2,4-Difluoronitrobenzene ISO 9001：2015 REACH 4-flouro-3-nitrobenzene sulfonic acid potassium salt high quality 2,4-Difluoronitrobenzene 2,4-Difluoronitrobenzene extrapure, 99% 2,4-DIFLUORO-1-NITROBENZENE 2,4- Di Fluoro Nitro Benzene (2,4 DFNB) 2,4-Difluoro-1-nitrobenzene, 98% 446-35-5 F2C6H3NO2 Building Blocks Nitro Compounds Organic Building Blocks Nitrogen Compounds Fluorine series alkyl Fluorine| nitro-compound HALIDE Aromatic Hydrocarbons (substituted) & Derivatives