15(S)-HETE
- CAS No.
- 54845-95-3
- Chemical Name:
- 15(S)-HETE
- Synonyms
- C04742;AL12959;AL 12959;AL-12959;Icomucret;15(S)-HETE;(S)-15-HETE;JSFATNQSLKRBCI-VAEKSGALSA-N;15(S)-HETE MaxSpec Standard;15(S)-HETE Lipid Maps MS Standard
- CBNumber:
- CB0724870
- Molecular Formula:
- C20H32O3
- Molecular Weight:
- 320.47
- MDL Number:
- MFCD00063590
- MOL File:
- 54845-95-3.mol
- MSDS File:
- SDS
| Boiling point | 487.7±45.0 °C(Predicted) |
|---|---|
| Density | 0.984±0.06 g/cm3(Predicted) |
| Flash point | 14℃ |
| storage temp. | -20°C |
| solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS (pH 7.2): 0.8 mg/ml |
| form | Liquid. |
| pka | 4.75±0.10(Predicted) |
| BRN | 2470466 |
| FDA UNII | 44JHK6G39Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P261-P305+P351+P338 | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 11-36/37/38 | |||||||||
| Safety Statements | 7-16-26-36 | |||||||||
| RIDADR | UN 1170 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
15(S)-HETE price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 34720 | 15(S)-HETE ≥98% | 54845-95-3 | 25μg | $39 | 2024-03-01 | Buy |
| Cayman Chemical | 10007251 | 15(S)-HETE MaxSpec? Standard ≥95% | 54845-95-3 | 100μg | $178 | 2024-03-01 | Buy |
| Cayman Chemical | 34720 | 15(S)-HETE ≥98% | 54845-95-3 | 50μg | $66 | 2024-03-01 | Buy |
| Cayman Chemical | 34720 | 15(S)-HETE ≥98% | 54845-95-3 | 100μg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 34720 | 15(S)-HETE ≥98% | 54845-95-3 | 500μg | $566 | 2024-03-01 | Buy |
15(S)-HETE Chemical Properties,Uses,Production
Description
15(S)-
Uses
15(S)-HETE is an arachidonic acid metabolite with immunosuppressive activity.
Uses
15(S)-HETE is a major arachidonic acid metabolite from the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE is present in μg/ml concentrations in the nasal secretions of allergic rhinitis.
Definition
ChEBI: An optically active form of 15-HETE having 15(S)-configuration..
General Description
15(S)-HETE is a product of the arachidonic acid pathway. It is synthesized by the human lungs and airway epithelial cells. 15(S)-HETE is a potent mucosecretagogue in human airways. It is a metabolite of 15-lipoxygenase. 15(S)-HETE is an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ).
Biochem/physiol Actions
Metabolite of arachidonic acid via the 15-lipoxygenase pathway that may be involved in pulmonary anti-inflammatory responses through the inhibition of 5-lipoxygenase. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.
15(S)-HETE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2210 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | root@zhongyitai.com | China | 1976 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |