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CNQX

CNQX structure

CAS No.: 115066-14-3

Chemical Name:: CNQX

Synonyms: CNQX;CNOX;FG-9065;CNQX 2NA;CNQX DISODIUM;CNQX DISODIUM SALT;CNQX disodium salt hydrate;CNQX DISODIUM KAINATE/AMPA RECEPTOR;CNQX (FG-9065) (6-CYANO-7-NITROQUINO;6-Nitro-7-cyanoquinoxaline-2,3-dione

CBNumber:: CB0728641

Molecular Formula:: C9H4N4O4

Molecular Weight:: 232.15

MDL Number:: MFCD00069232

MOL File:: 115066-14-3.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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CNQX Properties

Melting point	300 °C
Boiling point	374.31°C (rough estimate)
Density	1.5507 (rough estimate)
refractive index	1.6590 (estimate)
RTECS	VD1520000
storage temp.	protect from light
solubility	H₂O: 10 mg/mL
form	solid
pka	8.16±0.20(Predicted)
color	orange to red
Stability	Store Tightly Sealed at RT
CAS DataBase Reference	115066-14-3(CAS DataBase Reference)
FDA UNII	6OTE87SCCW

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Danger

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Safety Statements

22-24/25

WGK Germany

HS Code

29335990

NFPA 704

	0
3		0

CNQX price More Price(47)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C127	CNQX ≥98% (HPLC), solid	115066-14-3	5mg	$162	2024-03-01	Buy
Sigma-Aldrich	C127	CNQX ≥98% (HPLC), solid	115066-14-3	25mg	$546	2024-03-01	Buy
Sigma-Aldrich	5.04914	CNQX - CAS 115066-14-3 - Calbiochem	115066-14-3	10mg	$176	2024-03-01	Buy
Alfa Aesar	J63472	6-Cyano-7-nitro-1,4-dihydroquinoxaline-2,3-dione, 98%	115066-14-3	10mg	$133.65	2024-03-01	Buy
Alfa Aesar	J63472	6-Cyano-7-nitro-1,4-dihydroquinoxaline-2,3-dione, 98%	115066-14-3	25mg	$349.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
C127	5mg	$162	Buy
C127	25mg	$546	Buy
5.04914	10mg	$176	Buy
J63472	10mg	$133.65	Buy
J63472	25mg	$349.65	Buy

CNQX Chemical Properties,Uses,Production

Chemical Properties

Pale Yellow Solid

Uses

CNQX disodium salt hydrate has been used as:

as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)

Uses

A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively

Uses

CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors). This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors.

Definition

ChEBI: 6-Cyano-7-nitroquinoxaline-2,3-dione is a quinoxaline derivative.

Biological Activity

Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex.

Biochem/physiol Actions

Potent, competitive AMPA/kainate glutamate receptor antagonist.

storage

Room temperature

CNQX Preparation Products And Raw materials

Raw materials

Preparation Products

CNQX Suppliers

Global( 113)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12393	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Hefei TNJ Chemical Industry Co.,Ltd.	0551-65418684 +8618949823763	sales@tnjchem.com	China	25363	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Zhengzhou Alfa Chemical Co.,Ltd	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
AFINE CHEMICALS LIMITED	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58
Mainchem Co., Ltd.	55

View Lastest Price from CNQX manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-12	6-CYANO-7-NITROQUINOXALINE-2,3-DIONE 115066-14-3	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE
115066-14-3
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

CNQX Spectrum

CNQX(115066-14-3)¹HNMR

115066-14-3(CNQX)Related Search:

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4-ACETAMIDOBENZONITRILE 2,3-DIHYDROXYQUINOXALINE 3,4-Diaminobenzonitrile 4-ACETAMIDO-2-METHYLNITROBENZENE 6-NITROQUINOXALINE-2,3-DIONE

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1of4

7-Nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile 6-CYANO-7-NITROQUINOXALINE-2,3 (1H,4H)-DIONE CNQX CNQX 2NA CNQX DISODIUM CNQX DISODIUM SALT FG-9065 CNQX DISODIUM KAINATE/AMPA RECEPTOR CNQX (FG-9065) (6-CYANO-7-NITROQUINO 2,3-Dioxo-7-nitroquinoxaline-6-carbonitrile 6-Nitro-7-cyanoquinoxaline-2,3-dione CNOX 1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinecarbonitrile 7-Nitro-2,3-dihydroxyquinoxaline-6-carbonitrile 6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065 6-Cyano-2,3-dihydroxy-7-nitroquinoxaline 6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate CNQX disodium salt hydrate 7-Nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile 6-Quinoxalinecarbonitrile,1,2,3,4-tetrahydro-7-nitro-2,3-dioxo- 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE 2NA 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM 6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM SALT CNQX,6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065 1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxaline 115066-14-3 486724-17-2 C9H2N4Na2O4 C9H2N4O4Na2 C9H4N4O4 Cell Signaling and Neuroscience BioChemical Cell Biology Ligand-Gated Ion Channels Ionotropic Glutamate Receptor Modulators Ion Channels Heterocyclic Compounds Neurochemicals Glutamate receptor Glutamate Aromatics Heterocycles