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2-Amino-5-chloropyridine

2-Amino-5-chloropyridine structure

CAS No.: 1072-98-6

Chemical Name:: 2-Amino-5-chloropyridine

Synonyms: 5-CHLOROPYRIDIN-2-AMINE;5-CHLORO-2-AMINOPYRIDINE;80.8;AKOS 91155;TIMTEC-BB SBB000059;5-Chlor-2-pyridylamin;5-CHLORO-A-PYRIDYLAMINE;5-CHLORO-2-PYRIDYLAMINE;5-CHLORO-2-PYRIDINAMINE;2-Amino-5-Cloropyridine

CBNumber:: CB0736206

Molecular Formula:: C5H5ClN2

Molecular Weight:: 128.56

MDL Number:: MFCD00006324

MOL File:: 1072-98-6.mol

MSDS File:: SDS

Last updated:2025-05-15 16:04:47

Product description	Number	Pack Size	Price
2-Amino-5-chloropyridine 98%	A46803	25g	$27.1
2-Amino-5-chloropyridine British Pharmacopoeia (BP) Reference Standard	BP813	25MG	$255
2-Amino-5-chloropyridine 98%	A46803	100g	$82.9
2-Amino-5-chloropyridine >98.0%(GC)(T)	A0837	25g	$26
2-Amino-5-chloropyridine >98.0%(GC)(T)	A0837	100g	$91
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2-Amino-5-chloropyridine Properties

Melting point	135-138 °C (lit.)
Boiling point	127-128 °C/11 mmHg (lit.)
Density	1.2417 (rough estimate)
refractive index	1.5110 (estimate)
Flash point	160 °C
storage temp.	2-8°C
solubility	1.0g/l
pka	4.67±0.13(Predicted)
form	Crystalline Powder
color	Beige to beige-brown
Water Solubility	1 g/L (20 ºC)
BRN	108735
InChIKey	MAXBVGJEFDMHNV-UHFFFAOYSA-N
CAS DataBase Reference	1072-98-6(CAS DataBase Reference)
NIST Chemistry Reference	2-Amino-5-chloropyridine(1072-98-6)
EPA Substance Registry System	2-Amino-5-chloropyridine (1072-98-6)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302+H312+H332-H315-H319-H302-H312-H332-H335

Precautionary statements

P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501-P280h-P305+P351+P338

Hazard Codes

Xn,Xi

Risk Statements

22-36/37/38

Safety Statements

22-24/25-37/39-26-36

WGK Germany

Hazard Note

Harmful

HazardClass

IRRITANT

HS Code

29333999

NFPA 704

	1
1		0

2-Amino-5-chloropyridine price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A46803	2-Amino-5-chloropyridine 98%	1072-98-6	25g	$27.1	2025-07-31	Buy
Sigma-Aldrich	BP813	2-Amino-5-chloropyridine British Pharmacopoeia (BP) Reference Standard	1072-98-6	25MG	$255	2025-07-31	Buy
Sigma-Aldrich	A46803	2-Amino-5-chloropyridine 98%	1072-98-6	100g	$82.9	2025-07-31	Buy
TCI Chemical	A0837	2-Amino-5-chloropyridine >98.0%(GC)(T)	1072-98-6	25g	$26	2025-07-31	Buy
TCI Chemical	A0837	2-Amino-5-chloropyridine >98.0%(GC)(T)	1072-98-6	100g	$91	2025-07-31	Buy

Product number	Packaging	Price	Buy
A46803	25g	$27.1	Buy
BP813	25MG	$255	Buy
A46803	100g	$82.9	Buy
A0837	25g	$26	Buy
A0837	100g	$91	Buy

2-Amino-5-chloropyridine Chemical Properties,Uses,Production

Chemical Properties

beige to beige-brown crystalline powder

Uses

5-Chloro-2-pyridinamine is a useful synthetic intermediate. It can be used to synthesize zopiclone (Z700500) which is a cyclopyrrolone member of a family of non-benzodiazepine GABAA receptor agonists.

Reactions

2-Amino-5-chloropyridine can be used to electro-organically synthesize 6-aminonicotinic acid. 6-aminonicotinic acid is the main component of vitamin B3 and can be used to treat pellagra. The specific method is as follows:
In the presence of sulfuric acid and carbon dioxide, in dimethylformamide (DMF) solution, 5-chloro-2-nitropyridine 1 is electrochemically converted to 2-amino-5-chloropyridine 2 on a nickel cathode and a copper anode at an apparent current density of 10 mA/cm2 using a diaphragmless electrolytic cell, with a yield of up to 84%. Then 2 is reductively carboxylated to synthesize 6-aminonicotinic acid 3 on the cathode surface with a yield of 78%.
Reaction of 2-Amino-5-chloropyridine

Synthesis Reference(s)

The Journal of Organic Chemistry, 41, p. 93, 1976 DOI: 10.1021/jo00863a020

Toxicology

2-Amino-5-chloropyridine is an irritant, causing severe eye irritation, possibly skin and respiratory irritation, and harmful if ingested. The substance is non-mutagenic, but has a relatively high toxicity to zebrafish embryonic development, with embryonic malformation and mortality rates being concentration-dependent.

Purification Methods

Recrystallise this base from pet ether. It sublimes at 50o/0.5mm. [Beilstein 22 II 332, 22/8 V 541.]

2-Amino-5-chloropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

Zopiclone 5-Chloro-2-hydroxy-3-nitropyridine 2,5-Dichloro-3-nitropyridine 2,5-Dichloropyridin-3-amine ethyl 2-(6-aminopyridin-3-yl)acetate

6-chloro-[1,2,4]triazolo[1,5-a]pyridin-2-amine EthanediaMide iMpurity F 2-Bromo-5-chloropyridine 2-Bromo-5-chloro-3-nitropyridine 2-Amino-5-chloro-3-nitropyridine

3-AMINO-2-BROMO-5-CHLOROPYRIDINE 5-Chloropyridine-2-carboxylic acid

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2-Amino-5-chloropyridine Suppliers

Global( 835)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Beijing Wisdom Chemicals Co., Ltd.	+8613701363759	market@wisdomchem.com	China	254	58
Terma Medicare India Pvt.,Ltd	+86-53530655; +8613916485955	shivshanghai@yahoo.com	India	279	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8770	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	+8613288715578	sales@sichuanzyyt.com	China	12242	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5251	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1014	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20173	58
hebei hongtan Biotechnology Co., Ltd	+852-6619 3215 +86-17731935328	sales03@chemcn.cn	China	970	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	3692	58
Anhuyan (Hainan) Biotechnology Co., LTD	+86-18163349544; +8618163349544	mollylucking@foxmail.com	China	3000	58

Supplier	Advantage
Beijing Wisdom Chemicals Co., Ltd.	58
Terma Medicare India Pvt.,Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Sichuan Zhuoyu Yantang Technology Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hangzhou ICH Biofarm Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
hebei hongtan Biotechnology Co., Ltd	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	58
Anhuyan (Hainan) Biotechnology Co., LTD	58

2-Amino-5-chloropyridine: An In-Depth Exploration
2-Amino-5-chloropyridine is a chlorinated derivative of pyridine.
Oct 23，2024

View Lastest Price from 2-Amino-5-chloropyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-06	2-Amino-5-chloropyridine 1072-98-6	US $0.00 / gm	100gm	99%min	100kgs	Shanghai Yongzeng Technology Co.,Ltd
2025-11-06	2-Amino-5-chloropyridine 1072-98-6	US $0.00-0.00 / Kg/Drum	1KG	99%min	1000KGS	WUHAN FORTUNA CHEMICAL CO., LTD
2025-11-06	2-Amino-5-chloropyridine 1072-98-6	US $10.00 / kg	1kg	99%	100	Hebei Chuanghai Biotechnology Co., Ltd

2-Amino-5-chloropyridine
1072-98-6
US $0.00 / gm
99%min
Shanghai Yongzeng Technology Co.,Ltd

2-Amino-5-chloropyridine
1072-98-6
US $0.00-0.00 / Kg/Drum
99%min
WUHAN FORTUNA CHEMICAL CO., LTD

2-Amino-5-chloropyridine
1072-98-6
US $10.00 / kg
99%
Hebei Chuanghai Biotechnology Co., Ltd

2-Amino-5-chloropyridine Spectrum

2-Amino-5-chloropyridine(1072-98-6)MS 2-Amino-5-chloropyridine(1072-98-6)¹HNMR 2-Amino-5-chloropyridine(1072-98-6)¹³CNMR 2-Amino-5-chloropyridine(1072-98-6)IR1 2-Amino-5-chloropyridine(1072-98-6)IR2 2-Amino-5-chloropyridine(1072-98-6)Raman

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2-Amino-5-chloropyridine 5-Chloro-2-pyridineamine 5-Chloro-a-aminopyridine 2-Amino-5-chloropyridine ,98% 2-AMINO-5-CHLOROPYRIDINE 5-CHLORO-PYRIDIN-2-YLAMINE 2-Amino-5-chlorophridine 2-AMINO-5-CHLOROPYRIDINE FOR SYNTHESIS 2-aMino -5-chlorine pyridine TIMTEC-BB SBB000059 2-Pyridinamine, 5-chloro- Pyridine, 2-amino-5-chloro- AMINO(2-)-5-CHLOROPYRIDINE AKOS 91155 5-CHLOROPYRIDIN-2-YLAMINE 5-CHLORO-A-PYRIDYLAMINE 5-CHLORO-2-PYRIDYLAMINE 5-CHLORO-2-PYRIDINAMINE 2-AMINO-5-CHLIROPYRIDINE 2-Pyridinamine,5-chloro-(9CI) 2-Amino-5-Chloro Pyriine 2-AMINO-5-CHLOROPYRIDINE 99% 2-Amino-5-chloropyridine HPLC 99.5%Individual impurity = NMT 0.10 % 2-Amino-5-chloropyridine > 2-Bromo-3-Chloro-7-(Trifluoromethyl)Pyridine 2-Amino-5-chloropyridine ISO 9001：2015 REACH Edoxaban Impurity 37 / Zopiclone Impurity 1 5-Chlor-2-pyridylamin 5-CHLOROPYRIDIN-2-AMINE 5-CHLORO-2-AMINOPYRIDINE 2-Amino-5-Cloropyridine 2-Amino-5-chloropyridine 2 mino-5-chloropyridine 2-Amino-5-chloropyridine, 95% 80.8 2-Amino-5-chloropyridine - [A16397] Zopiclone Impurity: 2-Amino-5-chloropyridine 1072-98-6 C5H5CIN2 C5H5N2Cl Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks Halopyridines Chloropyridines Pyridines FINE Chemical & INTERMEDIATES Amines blocks PYRIDINE Nitrogen cyclic compounds Heterocycle-Pyridine series amine| alkyl chloride Pyridines derivates Chloropyridines Halopyridines C5Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks