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ACRIDINE ORANGE

ACRIDINE ORANGE
ACRIDINE ORANGE structure
CAS No.
65-61-2
Chemical Name:
ACRIDINE ORANGE
Synonyms
AO;AOX1;Lysotraker;CI NO 46005;BASIC ORANGE;-Cellstain-Ao;Euchrysine 3r;EUCHRYSINE 3RX;acridineoranger;N’-Tetramethyl-3
CBNumber:
CB0747468
Molecular Formula:
C17H20ClN3
Formula Weight:
301.81
MOL File:
65-61-2.mol

ACRIDINE ORANGE Properties

Melting point:
284-287 °C(lit.)
Density 
1.001 g/mL at 20 °C
refractive index 
n20/D 1.338
storage temp. 
-20°C
solubility 
Soluble in water, ethanol, dimethyl sulfoxide
form 
Powder
pka
-3.2, 10.5(at 25℃)
Colour Index 
46005
color 
orange to red
λmax
500 nm
BRN 
3734978
Major Application
Adhesives; aluminophosphate crystalline materials; detecting clay particles; display device; evaluating fiber surface characteristics; glass matrixes; imaging material; inks; lasers; recording materials; photoresists; textiles; thin films; tracers for hydrology; wiring boards
Biological Applications
Detecting cancer cells,spores,human papilloma virus (HPV),stress biomarkers; treating amyloid associated diseases,lupus,pathogen infections; apoptosis assays; cytotoxicity assays
CAS DataBase Reference
65-61-2
FDA UNII
YO2175B15I
EPA Substance Registry System
C.I. Basic Orange 14 (65-61-2)
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25
WGK Germany  3
RTECS  AR7601000
HS Code  32041300
Toxicity dnd-mus:ast 20 mmol/L BBACAQ 374,96,74

ACRIDINE ORANGE price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 318337 Acridine Orange hydrochloride hydrate 99% (HPLC) 65-61-2 1g $71.1 2020-08-18 Buy
Sigma-Aldrich 318337 Acridine Orange hydrochloride hydrate 99% (HPLC) 65-61-2 5g $307 2020-08-18 Buy
Sigma-Aldrich 318337 Acridine Orange hydrochloride hydrate 99% (HPLC) 65-61-2 250mg $24.2 2020-08-18 Buy
Sigma-Aldrich 113000 Acridine Orange - CAS 65-61-2 - Calbiochem 65-61-2 1gm $82.1 2020-08-18 Buy
Sigma-Aldrich A8097 Acridine Orange hydrochloride solution 10mg/mL in H 65-61-2 10ml $85.4 2021-03-22 Buy

ACRIDINE ORANGE Chemical Properties,Uses,Production

Chemical Properties

dark orange to brown powder

Uses

Acridine orange is a dye that interacts with DNA and RNA by intercelation or electrostatic attraction. This cationic dye has been used as a fluorescent stain for nucleic acids in agarose and polyacrylamide gels.

Preparation

4,4 ‘-Bis (N, N-dimethyl) aminodiphenylmethane obtained dinitration of 4,4′ – bis (N, N-dimethyl) amino-2 ‘- dinitro-diphenyl methane reduction, and with an acid of heat, so that the diamino compound is cyclized product is oxidized and then cyclized and converted into zinc chloride double salt.

Safety Profile

Mutation data reported. Whenheated to decomposition it emits very toxic fumes of HCl,Cl??, and NOx.

Enzyme inhibitor

This cell-permeable dye (FWfree-base = 265.36 g/mol; CAS 65-61-2), also known as N,N,N',N'-tetramethylacridine-3,6-diamine, is an intercalator that binds tightly to nucleic acids. Binding to DNA is characterized by excitation maximum at 502 nm (cyan) and an emission maximum at 525 nm, producing a green fluorescence. (A 120 μM solution of acridine orange will detect 25-50 ng DNA per band in an agarose or polyacrylamide gel.) Binding to RNA is characterized by an excitation maximum at 460 nm and the emission maximum is located at 650 nm, yielding a reddish-orange fluorescence. Acridine orange also penetrates acidic compartments (e.g., lysosomes and phagolysosomes); upon protonation, the dye emits orange light when excited by blue light.

Properties and Applications

bright yellow orange. Soluble in water and ethanol for orange yellow, with green fluorescent. The strong sulfuric acid in nearly colorless, a green fluorescent, diluted for orange. The dye solution with strong sodium hydroxide solution have yellow precipitation. And C.I. Solvent Orange 15 the same chemical structure (free base).
Standard( Silk ) Light Fastness Persperation Fastness Ironing Fastness Soaping
Fading Stain Fading Stain Fading Stain
ISO 1-2 3 1 5 1 3

ACRIDINE ORANGE Preparation Products And Raw materials

Raw materials

Preparation Products


ACRIDINE ORANGE Suppliers

Global( 86)Suppliers
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Hubei Jusheng Technology Co.,Ltd.
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BOC Sciences
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3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 821-50328103-801
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Beijing Ouhe Technology Co., Ltd 13552068683 010-82967028-
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Thermo Fisher Scientific 800-810-5118
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